Search Results - "Shelton, Holly"

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins by Conceicao, Carina, Thakur, Nazia, Human, Stacey, Kelly, James T, Logan, Leanne, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Zagrajek, Adrian K, Hollinghurst, Philippa, Varga, Michal, Tsirigoti, Christina, Tully, Matthew, Chiu, Chris, Moffat, Katy, Silesian, Adrian Paul, Hammond, John A, Maier, Helena J, Bickerton, Erica, Shelton, Holly, Dietrich, Isabelle, Graham, Stephen C, Bailey, Dalan

“…SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global…”
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A random priming amplification method for whole genome sequencing of SARS-CoV-2 virus by Chrzastek, Klaudia, Tennakoon, Chandana, Bialy, Dagmara, Freimanis, Graham, Flannery, John, Shelton, Holly

“…Non-targeted whole genome sequencing is a powerful tool to comprehensively identify constituents of microbial communities in a sample. There is no need to…”
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PB1-F2 of low pathogenicity H7N7 restricts apoptosis in avian cells by Hohensee, Luise, Scheibner, David, Luttermann, Christine, Shelton, Holly, Dorhoi, Anca, Abdelwhab, Elsayed M., Blohm, Ulrike

“…•In chicken full-length PB1-F2 of LPAIV H7N7 prolonged survival of infected cells by limiting apoptotic cell death.•PB1-F2 knockout LPAIV significantly…”
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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family by Idoko-Akoh, Alewo, Goldhill, Daniel H., Sheppard, Carol M., Bialy, Dagmara, Quantrill, Jessica L., Sukhova, Ksenia, Brown, Jonathan C., Richardson, Samuel, Campbell, Ciara, Taylor, Lorna, Sherman, Adrian, Nazki, Salik, Long, Jason S., Skinner, Michael A., Shelton, Holly, Sang, Helen M., Barclay, Wendy S., McGrew, Mike J.

“…Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we…”
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Species specific differences in use of ANP32 proteins by influenza A virus by Long, Jason S, Idoko-Akoh, Alewo, Mistry, Bhakti, Goldhill, Daniel, Staller, Ecco, Schreyer, Jocelyn, Ross, Craig, Goodbourn, Steve, Shelton, Holly, Skinner, Michael A, Sang, Helen, McGrew, Michael J, Barclay, Wendy

“…Influenza A viruses (IAV) are subject to species barriers that prevent frequent zoonotic transmission and pandemics. One of these barriers is the poor activity…”
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The Short Stalk Length of Highly Pathogenic Avian Influenza H5N1 Virus Neuraminidase Limits Transmission of Pandemic H1N1 Virus in Ferrets by Blumenkrantz, Deena, Roberts, Kim L, Shelton, Holly, Lycett, Samantha, Barclay, Wendy S

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Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential by Sealy, Joshua E, Yaqub, Tahir, Peacock, Thomas P, Chang, Pengxiang, Ermetal, Burcu, Clements, Anabel, Sadeyen, Jean-Remy, Mehboob, Arslan, Shelton, Holly, Bryant, Juliet E, Daniels, Rod S, McCauley, John W, Iqbal, Munir

“…We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014-2016 and found that the hemagglutinin gene is of the G1 lineage and that…”
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The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens by Hohensee, Luise, Scheibner, David, Schäfer, Alexander, Shelton, Holly, Mettenleiter, Thomas C, Breithaupt, Angele, Dorhoi, Anca, Abdelwhab, Elsayed M, Blohm, Ulrike

“…Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically…”
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Animal Models in Influenza Research by Hemmink, Johanneke D, Whittaker, Catherine J, Shelton, Holly A

“…Animal model systems for human and animal influenza virus infection and transmission have been established to address research questions which cannot be…”
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Mapping the interaction sites of human and avian influenza A viruses and complement factor H by Rabeeah, Iman, Billington, Elizabeth, Nal, Béatrice, Sadeyen, Jean-Remy, Pathan, Ansar A, Iqbal, Munir, Temperton, Nigel J, Zipfel, Peter F, Skerka, Christine, Kishore, Uday, Shelton, Holly

“…The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical,…”
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Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice by Li, Hui, Bradley, Konrad C, Long, Jason S, Frise, Rebecca, Ashcroft, Jonathan W, Hartgroves, Lorian C, Shelton, Holly, Makris, Spyridon, Johansson, Cecilia, Cao, Bin, Barclay, Wendy S

“…The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and…”
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CD4+TGFβ+ cells infiltrated the bursa of Fabricius following IBDV infection, and correlated with a delayed viral clearance, but did not correlate with disease severity, or immunosuppression by Nazki, Salik, Reddy, Vishwanatha R. A. P., Kamble, Nitin, Sadeyen, Jean-Remy, Iqbal, Munir, Behboudi, Shahriar, Shelton, Holly, Broadbent, Andrew J.

“…Introduction Infectious Bursal Disease Virus (IBDV) causes immunosuppression in chickens. While B-cell destruction is the main cause of humoral…”
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Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines by Chrzastek, Klaudia, Leng, Joy, Zakaria, Mohammad Khalid, Bialy, Dagmara, La Ragione, Roberto, Shelton, Holly

“…Abstract Background A commensal microbiota regulates and is in turn regulated by viruses during host infection which can influence virus infectivity. In this…”
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Alteration of the Chicken Upper Respiratory Microbiota, Following H9N2 Avian Influenza Virus Infection by Davis, Tara, Bialy, Dagmara, Leng, Joy, La Ragione, Roberto, Shelton, Holly, Chrzastek, Klaudia

“…Several studies have highlighted the importance of the gut microbiota in developing immunity against viral infections in chickens. We have previously shown…”
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Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model by Roberts, Kim L, Shelton, Holly, Stilwell, Peter, Barclay, Wendy S

“…During the early phase of the 2009 influenza pandemic, attempts were made to contain the spread of the virus. Success of reactive control measures may be…”
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Adjuvant-Free Immunization with Hemagglutinin-Fc Fusion Proteins as an Approach to Influenza Vaccines by Loureiro, Silvia, Ren, Junyuan, Phapugrangkul, Pongsathon, Colaco, Camilo A, Bailey, Christopher R, Shelton, Holly, Molesti, Eleonora, Temperton, Nigel J, Barclay, Wendy S, Jones, Ian M

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Receptor Binding Profiles of Avian Influenza Virus Hemagglutinin Subtypes on Human Cells as a Predictor of Pandemic Potential by Shelton, Holly, Ayora-Talavera, Guadalupe, Ren, Junyuan, Loureiro, Silvia, Pickles, Raymond J, Barclay, Wendy S, Jones, Ian M

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Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium by Ayora-Talavera, Guadalupe, Shelton, Holly, Scull, Margaret A, Ren, Junyuan, Jones, Ian M, Pickles, Raymond J, Barclay, Wendy S

“…The emergence in 2009 of a swine-origin H1N1 influenza virus as the first pandemic of the 21st Century is a timely reminder of the international public health…”
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Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction by Shelton, Holly, Harris, Mark

“…The hepatitis C virus (HCV) non-structural 5A protein (NS5A) contains a highly conserved C-terminal polyproline motif with the consensus sequence…”
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A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets by van Doremalen, Neeltje, Shelton, Holly, Roberts, Kim L, Jones, Ian M, Pickles, Ray J, Thompson, Catherine I, Barclay, Wendy S

“…The first pandemic of the 21(st) century, pandemic H1N1 2009 (pH1N1 2009), emerged from a swine-origin source. Although human infections with swine-origin…”
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