Search Results - "Shelton, Catherine D."
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5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium
Published in mBio (19-01-2021)“…5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of…”
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Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors
Published in mSphere (14-10-2020)“…Mycobacterium tuberculosis is a major global human pathogen, and new drugs and new drug targets are urgently required. Cell wall biosynthesis is a major target…”
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Gut Epithelial Metabolism as a Key Driver of Intestinal Dysbiosis Associated with Noncommunicable Diseases
Published in Infection and immunity (22-06-2020)“…In high-income countries, the leading causes of death are noncommunicable diseases (NCDs), such as obesity, cancer, and cardiovascular disease. An important…”
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High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N -oxide
Published in Science (American Association for the Advancement of Science) (13-08-2021)“…A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut…”
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In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
Published in Antimicrobial agents and chemotherapy (01-10-2017)“…Oxazolidinones are promising candidates for the treatment of infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878…”
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Correction for Shelton et al., “Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis”
Published in Antimicrobial agents and chemotherapy (16-08-2022)Get full text
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Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance
Published in Cell reports (Cambridge) (04-01-2022)“…The gut microbiota benefits the host by limiting enteric pathogen expansion (colonization resistance), partially via the production of inhibitory metabolites…”
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Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis
Published in Antimicrobial agents and chemotherapy (19-04-2021)“…Tuberculosis, caused by , is an urgent global health problem requiring new drugs, new drug targets and an increased understanding of antibiotic resistance. We…”
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An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism
Published in Cell host & microbe (11-10-2023)“…The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse…”
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Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis
Published in Cell host & microbe (12-06-2024)“…Inflammation boosts the availability of electron acceptors in the intestinal lumen, creating a favorable niche for pathogenic Enterobacteriaceae. However, the…”
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Ribosomal protein L7/L12 is required for GTPase translation factors EF‐G, RF3, and IF2 to bind in their GTP state to 70S ribosomes
Published in The FEBS journal (01-06-2017)“…Ribosomal protein L7/L12 is associated with translation initiation, elongation, and termination by the 70S ribosome. The guanosine 5′ triphosphate hydrolase…”
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Ribosomal protein L7/L12 is required for GTP ase translation factors EF ‐G, RF 3, and IF 2 to bind in their GTP state to 70S ribosomes
Published in The FEBS journal (01-06-2017)“…Ribosomal protein L7/L12 is associated with translation initiation, elongation, and termination by the 70S ribosome. The guanosine 5′ triphosphate hydrolase (…”
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