Search Results - "Shell, Steven M"

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responses by Zou, Yue, Liu, Yiyong, Wu, Xiaoming, Shell, Steven M.

“…Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined as a eukaryotic single‐stranded DNA binding (SSB) protein essential…”
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Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC by Fast, Olivia G, Gentry, Brittany, Strouth, Liah, Niece, Madison B, Beckford, Floyd A, Shell, Steven M

“…Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been…”
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Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A by Shell, Steven M., Li, Zhengke, Shkriabai, Nikolozi, Kvaratskhelia, Mamuka, Brosey, Chris, Serrano, Moises A., Chazin, Walter J., Musich, Phillip R., Zou, Yue

“…In response to DNA damage, eukaryotic cells activate a series of DNA damage-dependent pathways that serve to arrest cell cycle progression and remove DNA…”
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XPF-ERCC1: On the Bubble by Shell, Steven M., Chazin, Walter J.

“…In this issue of Structure, Das et al. report the structure of the helix-hairpin-helix dimerization domain of XPF bound to ssDNA. These results provide insight…”
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Redefining the DNA-Binding Domain of Human XPA by Sugitani, Norie, Shell, Steven M., Soss, Sarah E., Chazin, Walter J.

“…Xeroderma pigmentosum complementation group A (XPA) protein plays a critical role in the repair of DNA damage via the nucleotide excision repair (NER) pathway…”
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Mitochondrial mRNA fragments are circularized in a human HEK cell line by Mance, Landon G., Mawla, Ishaat, Shell, Steven M., Cahoon, A. Bruce

“…•Un-translatable fragments of mitochondrial mRNAs are circularized.•The circularized versions of the mRNAs comprise a small portion (~10%) of the total mRNA…”
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Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: Biological activity and carbon monoxide-releasing properties by Lawrence, Madelyn L., Shell, Steven M., Beckford, Floyd A.

“…[Display omitted] •Thiosemicarbazones are excellent ligands for photoactivable complexes.•Good antibacterial activity is observed against Gram(+) and Gram(−)…”
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Modulating Excited State Properties and Ligand Ejection Kinetics in Ruthenium Polypyridyl Complexes Designed to Mimic Photochemotherapeutics by Robinette, Faith N., Valentine, Nathaniel P., Sehler, Konrad M., Medeck, Andrew M., Reynolds, Keylon E., Lane, Skylar N., Price, Averie N., Cavanaugh, Ireland G., Shell, Steven M., Ashford, Dennis L.

“…Ruthenium­(II) polypyridyl complexes have gained significant interest as photochemotherapeutics (PCTs) due to their synthetic viability, strong light…”
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Chemistry and biology of manganese carbon-releasing molecules containing thiosemicarbazone ligands by Daniels, Hannah G., Fast, Olivia G., Shell, Steven M., Beckford, Floyd A.

“…[Display omitted] •Thiosemicarbazones are excellent ligands for fast photoactivable complexes.•Compounds have high chemical potential that may be related to…”
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XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner by Musich, Phillip R., Li, Zhengke, Shell, Steven M., Zou, Yue

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Reprint of: XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner by Musich, Phillip R., Li, Zhengke, Shell, Steven M., Zou, Yue

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Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA by Shell, Steven M., Hawkins, Edward K., Tsai, Miaw-Sheue, Hlaing, Aye Su, Rizzo, Carmelo J., Chazin, Walter J.

“…•High-throughput fluorescence anisotropy assay used to measure affinity of human XPC for damaged DNA.•Binding affinity tested for eight DNA lesions contained…”
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Dimerization and phosphatase activity of calcyclin‐binding protein/Siah‐1 interacting protein: the influence of oxidative stress by Topolska‐Woś, Agnieszka M., Shell, Steven M., Kilańczyk, Ewa, Szczepanowski, Roman H., Chazin, Walter J., Filipek, Anna

“…ABSTRACT CacyBP/SIP [calcyclin‐binding protein/Siah‐1 [seven in absentia homolog 1 (Siah E3 ubiquitin protein ligase 1)] interacting protein] is a…”
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Interaction and colocalization of Rad9 Rad1 Hus1 checkpoint complex with replication protein A in human cells by XIAOMING WU, SHELL, Steven M, YUE ZOU

“…Replication protein A (RPA) is a eukaryotic single-stranded DNA-binding protein consisting of three subunits of 70-, 32-, and 14-kDa (RPA70, RPA32, RPA14,…”
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Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation by XIAOMING WU, SHELL, Steven M, ZHENGGUAN YANG, YUE ZOU

“…DNA damage triggers complex cellular responses in eukaryotic cells, including initiation of DNA repair and activation of cell cycle checkpoints. In addition to…”
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Other proteins interacting with XP proteins by Shell, Steven M, Zou, Yue

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Protein Modification by Adenine Propenal by Shuck, Sarah C, Wauchope, Orrette R, Rose, Kristie L, Kingsley, Philip J, Rouzer, Carol A, Shell, Steven M, Sugitani, Norie, Chazin, Walter J, Zagol-Ikapitte, Irene, Boutaud, Olivier, Oates, John A, Galligan, James J, Beavers, William N, Marnett, Lawrence J

“…Base propenals are products of the reaction of DNA with oxidants such as peroxynitrite and bleomycin. The most reactive base propenal, adenine propenal, is…”
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Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A by Liu, Yiyong, Wang, Youjie, Rusinol, Antonio E, Sinensky, Michael S, Liu, Ji, Shell, Steven M, Zou, Yue

“…Cellular accumulation of DNA damage has been widely implicated in cellular senescence, aging, and premature aging. In Hutchinson-Gilford progeria syndrome…”
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Specific and Efficient Binding of Xeroderma Pigmentosum Complementation Group A to Double-Strand/Single-Strand DNA Junctions with 3‘- and/or 5‘-ssDNA Branches by Yang, Zhengguan, Roginskaya, Marina, Colis, Laureen C, Basu, Ashis K, Shell, Steven M, Liu, Yiyong, Musich, Phillip R, Harris, Constance M, Harris, Thomas M, Zou, Yue

“…Human XPA is an important DNA damage recognition protein in nucleotide excision repair (NER). We previously observed that XPA binds to the DNA lesion as a…”
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Mass Spectrometric Identification of Lysines Involved in the Interaction of Human Replication Protein A with Single-Stranded DNA by Shell, Steven M, Hess, Sonja, Kvaratskhelia, Mamuka, Zou, Yue

“…Human replication protein A (hRPA), a heterotrimeric single-stranded DNA (ssDNA) binding protein, is required for many cellular pathways including DNA damage…”
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