Search Results - "Shelkar, Gajanan P."

Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model by Ravikrishnan, Aparna, Gandhi, Pauravi J., Shelkar, Gajanan P., Liu, Jinxu, Pavuluri, Ratnamala, Dravid, Shashank M.

“…[Display omitted] •GluN2C is expressed in parvalbumin-positive neurons in a subset of basal ganglia nuclei.•GluN2C is localized to astrocytes in majority of…”
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GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility by Gawande, Dinesh Y., Shelkar, Gajanan P., Narasimhan, Kishore Kumar S., Liu, Jinxu, Dravid, Shashank M.

“…Thalamic regulation of cortical function is important for several behavioral aspects including attention and sensorimotor control. This region has also been…”
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Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model by Liu, Jinxu, Shelkar, Gajanan P., Sarode, Lopmudra P., Gawande, Dinesh Y., Zhao, Fabao, Clausen, Rasmus Praetorius, Ugale, Rajesh R., Dravid, Shashank Manohar

“…Globus pallidus externa (GPe) is a nucleus in the basal ganglia circuitry involved in the control of movement. Recent studies have demonstrated a critical role…”
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Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity by Liu, Jinxu, Shelkar, Gajanan P., Gandhi, Pauravi J., Gawande, Dinesh Y., Hoover, Andrew, Villalba, Rosa M., Pavuluri, Ratnamala, Smith, Yoland, Dravid, Shashank M.

“…Impaired behavioral flexibility and repetitive behavior is a common phenotype in autism and other neuropsychiatric disorders, but the underlying synaptic…”
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A simple and inexpensive method to fabricate a cannula system for intracranial injections in rats and mice by Kokare, Dadasaheb M., Shelkar, Gajanan P., Borkar, Chandrashekhar D., Nakhate, Kartik T., Subhedar, Nishikant K.

“…Stereotaxic administration of neuroactive agents, either in ventricles, or targeted at specific intracranial sites, is a widely employed strategy for…”
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Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain by Gandhi, Pauravi J, Gawande, Dinesh Y, Shelkar, Gajanan P, Gakare, Sukanya G, Kiritoshi, Takaki, Ji, Guangchen, Misra, Bishal, Pavuluri, Ratnamala, Liu, Jinxu, Neugebauer, Volker, Dravid, Shashank M

“…Chronic pain is a debilitating condition involving neuronal dysfunction, but the synaptic mechanisms underlying the persistence of pain are still poorly…”
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Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction by Shelkar, Gajanan P, Liu, Jinxu, Dravid, Shashank M

“…Abstract Background Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-site agonist D-cycloserine is known to facilitate fear…”
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GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia by Gawande, Dinesh Y., S. Narasimhan, Kishore Kumar, Shelkar, Gajanan P., Pavuluri, Ratnamala, Stessman, Holly A.F., Dravid, Shashank M.

“…Parvalbumin interneuron (PVI) activity synchronizes the medial prefrontal cortex circuit for normal cognitive function, and its impairment may contribute to…”
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Ultrastructural localization of glutamate delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum by Hoover, Andrew H., Pavuluri, Ratnamala, Shelkar, Gajanan P., Dravid, Shashank M., Smith, Yoland, Villalba, Rosa M.

“…The glutamate receptor delta 1 (GluD1) is strongly expressed in the striatum. Knockout of GluD1 expression in striatal neurons elicits cognitive deficits and…”
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Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain by Sabnis, Siddhesh S, S Narasimhan, Kishore Kumar, Chettiar, Poojashree B, Gakare, Sukanya G, Shelkar, Gajanan P, Asati, Devansh G, Thakur, Shriti S, Dravid, Shashank M

“…Chronic pain remains a major clinical problem that needs effective therapeutic agents. Glutamate delta 1 (GluD1) receptors and the protein cerebellin 1 (Cbln1)…”
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Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors by Gawande, Dinesh Y., Shelkar, Gajanan P., Liu, Jinxu, Ayala, Anna D., Pavuluri, Ratnamala, Choi, Diane, Smith, Yoland, Dravid, Shashank M.

“…Glutamate delta-1 receptor (GluD1) is a member of the ionotropic glutamate receptor family expressed at excitatory synapses and functions as a synaptogenic…”
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The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation by Somalwar, Amita R., Shelkar, Gajanan P., Subhedar, Nishikant K., Kokare, Dadasaheb M.

“…•Intracranial self-stimulation (ICSS) was facilitated by CART.•ICSS resulted in robust activation of CART cells in the LH.•ICSS induced synaptic plasticity in…”
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Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex by Gawande, Dinesh Y., S. Narasimhan, Kishore Kumar, Bhatt, Jay M., Pavuluri, Ratnamala, Kesherwani, Varun, Suryavanshi, Pratyush S., Shelkar, Gajanan P., Dravid, Shashank M.

“…The glutamate delta family of receptors is composed of GluD1 and GluD2 and serve as synaptic organizers. We have previously demonstrated several autism-like…”
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Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens by Shelkar, Gajanan P, Gandhi, Pauravi J, Liu, Jinxu, Dravid, Shashank M

“…Cocaine-associated memories induce cravings and interfere with the ability of users to cease cocaine use. Reducing the strength of cue-drug memories by…”
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Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes by Shelkar, Gajanan P., Pavuluri, Ratnamala, Gandhi, Pauravi J., Ravikrishnan, Aparna, Gawande, Dinesh Y., Liu, Jinxu, Stairs, Dustin J., Ugale, Rajesh R., Dravid, Shashank M.

“…The GluN2C- and GluN2D-containing NMDA receptors are distinct from GluN2A- and GluN2B-containing receptors in many aspects including lower sensitivity to Mg 2+…”
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Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens by Liu, Jinxu, Gandhi, Pauravi J., Pavuluri, Ratnamala, Shelkar, Gajanan P., Dravid, Shashank M.

“…Cocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), which has been proposed to…”
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Interactions of nitric oxide with α2‐adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine by Shelkar, Gajanan P, Gakare, Sukanya G, Chakraborty, Suwarna, Dravid, Shashank M, Ugale, Rajesh R

“…Background and Purpose Agmatine, a putative neurotransmitter, plays a vital role in learning and memory. Although it is considered an endogenous ligand of…”
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Transient receptor potential vanilloid 3 (TRPV3) in the ventral tegmental area of rat: Role in modulation of the mesolimbic-dopamine reward pathway by Singh, Uday, Kumar, Santosh, Shelkar, Gajanan P., Yadav, Manoj, Kokare, Dadasaheb M., Goswami, Chandan, Lechan, Ronald M., Singru, Praful S.

“…While dopamine (DA) neurons in the ventral tegmental area (VTA) drive the mesolimbic-reward pathway, confluent lines of evidence underscore the importance of…”
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Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats by Taksande, Brijesh G, Kotagale, Nandkishor R, Patel, Mital R, Shelkar, Gajanan P, Ugale, Rajesh R, Chopde, Chandrabhan T

“…Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats. The…”
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CART modulates the effects of levodopa in rat model of Parkinson’s disease by Upadhya, Manoj A., Shelkar, Gajanan P., Subhedar, Nishikant K., Kokare, Dadasaheb M.

“…•Apomorphine challenge produced contralateral rotations in Parkinson’s induced rats.•Levodopa (dopamine precursor) treatment showed contralateral rotations…”
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