Search Results - "Sheldon, I. Martin"

Pathogen-Associated Molecular Patterns Initiate Inflammation and Perturb the Endocrine Function of Bovine Granulosa Cells From Ovarian Dominant Follicles via TLR2 and TLR4 Pathways by Price, Jennifer C, Bromfield, John J, Sheldon, I. Martin

“…Bacterial infections of the uterus or mammary gland commonly cause disease and infertility by perturbing growth and steroidogenesis of the dominant follicle in…”
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Lipopolysaccharide Reduces the Primordial Follicle Pool in the Bovine Ovarian Cortex Ex Vivo and in the Murine Ovary In Vivo by BROMFIELD, John J, MARTIN SHELDON, I

“…Infections of the uterus or mammary gland with Gram-negative bacteria cause infertility in cattle, not only during disease but also for some time afterward…”
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Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro by Bromfield, John J, Sheldon, I. Martin

“…Infections of the reproductive tract or mammary gland with Gram-negative bacteria perturb ovarian function, follicular growth, and fecundity in cattle. We…”
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Diagnosing postpartum endometritis in dairy cattle by Sheldon, I. Martin

“…The arrow indicates pus discharging from the vulva It is important for vets to be able to diagnose endometritis accurately because the disease can cause…”
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Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle by Sheldon, I. Martin, Cronin, James G, Bromfield, John J

“…Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows tolerated these bacteria and few animals developed uterine disease. Now,…”
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Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes by Griffin, Sholeem, Healey, Gareth D, Sheldon, I. Martin

“…Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after…”
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Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle by Sheldon, I. Martin, Cronin, James, Goetze, Leopold, Donofrio, Gaetano, Schuberth, Hans-Joachim

“…Uterine microbial disease affects half of all dairy cattle after parturition, causing infertility by disrupting uterine and ovarian function. Infection with…”
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Toll-Like Receptor 4 and MYD88-Dependent Signaling Mechanisms of the Innate Immune System Are Essential for the Response to Lipopolysaccharide by Epithelial and Stromal Cells of the Bovine Endometrium by CRONIN, James G, TURNER, Matthew L, GOETZE, Leopold, BRYANT, Clare E, MARTIN SHELDON, I

“…Infection of the bovine endometrium with Gram-negative bacteria commonly causes uterine disease. Toll-like receptor 4 (TLR4) on cells of the immune system bind…”
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Metabolic stress and endometritis in dairy cattle by Sheldon, I. Martin

“…Low blood concentrations of IGF-1 reflect negative energy balance in peripartum cows, and are associated with uterine disease and infertility.2,3 Valdmann and…”
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Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease by Piersanti, Rachel L, Horlock, Anthony D, Block, Jeremy, Santos, José E P, Sheldon, I Martin, Bromfield, John J

“…Metritis is associated with reduced fertility in dairy cows, but the mechanisms are unclear because the disease resolves several weeks before insemination. One…”
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Specific Strains of Escherichia coli Are Pathogenic for the Endometrium of Cattle and Cause Pelvic Inflammatory Disease in Cattle and Mice by Sheldon, I. Martin, Rycroft, Andrew N, Dogan, Belgin, Craven, Melanie, Bromfield, John J, Chandler, Alyssa, Roberts, Mark H, Price, Sian B, Gilbert, Robert O, Simpson, Kenneth W

“…Background: Escherichia coli are widespread in the environment and pathogenic strains cause diseases of mucosal surfaces including the female genital tract…”
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Innate immunity and inflammation of the bovine female reproductive tract in health and disease by Sheldon, I Martin, Cronin, James G, Healey, Gareth D, Gabler, Christoph, Heuwieser, Wolfgang, Streyl, Dominik, Bromfield, John J, Miyamoto, Akio, Fergani, Chrys, Dobson, Hilary

“…Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators…”
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Defining postpartum uterine disease in cattle by Sheldon, I. Martin, Lewis, Gregory S., LeBlanc, Stephen, Gilbert, Robert O.

“…Uterine function is often compromised in cattle by bacterial contamination of the uterine lumen after parturition, and pathogenic bacteria often persist,…”
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Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows by Molinari, Paula C.C., Davidson, Brittney D., Laporta, Jimena, Dahl, Geoffrey E., Sheldon, I. Martin, Bromfield, John J.

“…Uterine diseases and heat stress (HS) are major challenges for the dairy cow. Heat stress alters host immune resilience, making cows more susceptible to the…”
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Glutamine supports the protection of tissue cells against the damage caused by cholesterol-dependent cytolysins from pathogenic bacteria by Turner, Matthew L, Owens, Sian E, Sheldon, I Martin

“…Pathogenic bacteria often damage tissues by secreting toxins that form pores in cell membranes, and the most common pore-forming toxins are…”
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Induced endometrial inflammation compromises conceptus development in dairy cattle by Husnain, Ali, Arshad, Usman, Zimpel, Roney, Schmitt, Eduardo, Dickson, Mackenzie J., Perdomo, Milerky C., Marinho, Mariana N., Ashrafi, Nadia, Graham, Stewart F., Bishop, Jeanette V., Hansen, Thomas R., Jeong, Kwang C., Gonella-Diaza, Angela M., Chebel, Ricardo C., Sheldon, I. Martin, Bromfield, John J., Santos, José E.P.

“…Endometrial inflammation is associated with reduced pregnancy per artificial insemination (AI) and increased pregnancy loss in cows. It was hypothesized that…”
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Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1 by Healy, Laura L., Cronin, James G., Sheldon, I. Martin

“…Cells generate inflammatory responses to bacteria when pattern recognition receptors bind pathogen-associated molecules such as lipopolysaccharide. Cells may…”
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Risk factors for clinical endometritis in postpartum dairy cattle by Potter, Timothy J., Guitian, Javier, Fishwick, John, Gordon, Patrick J., Sheldon, I. Martin

“…Bacterial contamination of the uterine lumen after parturition occurs in most dairy cattle. The presence of clinical endometritis beyond three weeks post…”
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The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection by Dickson, Mackenzie J, Bishop, Jeanette V, Hansen, Thomas R, Sheldon, I Martin, Bromfield, John J

“…Pregnancy induces changes in the transcriptome of the bovine endometrium from 15 days after insemination. However, pregnancy is less likely to occur if cows…”
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Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells by Chaney, Heather L., Grose, Lindsay F., Charpigny, Gilles, Behura, Susanta K., Sheldon, I. Martin, Cronin, James G., Lonergan, Patrick, Spencer, Thomas E., Mathew, Daniel J.

“…Bovine endometrium consists of epithelial and stromal cells that respond to conceptus interferon tau (IFNT), the maternal recognition of pregnancy (MRP)…”
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