Search Results - "Shelby, Sarah A"

Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting by Veatch, Sarah L, Machta, Benjamin B, Shelby, Sarah A, Chiang, Ethan N, Holowka, David A, Baird, Barbara A

“…We present an analytical method using correlation functions to quantify clustering in super-resolution fluorescence localization images and electron microscopy…”
Get full text

Distinct Stages of Stimulated FcεRI Receptor Clustering and Immobilization Are Identified through Superresolution Imaging by Shelby, Sarah A., Holowka, David, Baird, Barbara, Veatch, Sarah L.

“…Recent advances in fluorescence localization microscopy have made it possible to image chemically fixed and living cells at 20 nm lateral resolution. We apply…”
Get full text

Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes by Stone, Matthew B, Shelby, Sarah A, Núñez, Marcos F, Wisser, Kathleen, Veatch, Sarah L

“…Diverse cellular signaling events, including B cell receptor (BCR) activation, are hypothesized to be facilitated by domains enriched in specific plasma…”
Get full text

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers by Chen, Ritchie, Nam, Ki Tae, Tan, Li, Chu, Tammy K, Connolly, Michael D, Choi, Philip H, Zuckermann, Ronald N, Shelby, Sarah A, Mesch, Ryan A, Marciel, Amanda B, Lee, Byoung-Chul, Kisielowski, Christian

“…The design and synthesis of protein-like polymers is a fundamental challenge in materials science. A biomimetic approach is to explore the impact of monomer…”
Get full text

Rab11 Regulates the Mast Cell Exocytic Response by Wilson, Joshua D., Shelby, Sarah A., Holowka, David, Baird, Barbara

“…Stimulated exocytic events provide a means for physiological communication and are a hallmark of the mast cell‐mediated allergic response. In mast cells these…”
Get full text

Super-Resolution Microscopy: Shedding Light on the Cellular Plasma Membrane by Stone, Matthew B, Shelby, Sarah A, Veatch, Sarah L

“…Lipids and the membranes they form are fundamental building blocks of cellular life, and their geometry and chemical properties distinguish membranes from…”
Get full text

Membrane phase separation drives responsive assembly of receptor signaling domains by Shelby, Sarah A., Castello-Serrano, Ivan, Wisser, Kathleen C., Levental, Ilya, Veatch, Sarah L.

“…Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often explained by analogy to membrane phase separation; however, models…”
Get full text

The plasma membrane as an adaptable fluid mosaic by Veatch, Sarah L, Rogers, Nat, Decker, Adam, Shelby, Sarah A

“…The fluid mosaic model proposed by Singer and Nicolson established a powerful framework to interrogate biological membranes that has stood the test of time…”
Get more information

The Membrane Phase Transition Gives Rise to Responsive Plasma Membrane Structure and Function by Shelby, Sarah A, Veatch, Sarah L

“…Several groups have recently reported evidence for the emergence of domains in cell plasma membranes when membrane proteins are organized by ligand binding or…”
Get more information

The membrane phase transition drives tunable assembly and function of B cell receptor signaling domains by Shelby, Sarah A., Castello Serrano, Ivan, Levental, Ilya, Veatch, Sarah L.

Get full text

Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function by Salter, Alexander I, Rajan, Anusha, Kennedy, Jacob J, Ivey, Richard G, Shelby, Sarah A, Leung, Isabel, Templeton, Megan L, Muhunthan, Vishaka, Voillet, Valentin, Sommermeyer, Daniel, Whiteaker, Jeffrey R, Gottardo, Raphael, Veatch, Sarah L, Paulovich, Amanda G, Riddell, Stanley R

“…Chimeric antigen receptor (CAR)-modified T cell therapy is effective in treating lymphomas, leukemias, and multiple myeloma in which the tumor cells express…”
Get more information

Measuring the Co-Localization and Dynamics of Mobile Proteins in Live Cells Undergoing Signaling Responses by Shelby, Sarah A, Shaw, Thomas R, Veatch, Sarah L

“…Single molecule imaging in live cells enables the study of protein interactions and dynamics as they participate in signaling processes. When combined with…”
Get more information

SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics by Karslake, Joshua D., Donarski, Eric D., Shelby, Sarah A., Demey, Lucas M., DiRita, Victor J., Veatch, Sarah L., Biteen, Julie S.

“…[Display omitted] Single-molecule fluorescence microscopy probes nanoscale, subcellular biology in real time. Existing methods for analyzing single-particle…”
Get full text

Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling by Shelby, Sarah A, Veatch, Sarah L, Holowka, David A, Baird, Barbara A

“…The allergic response is initiated on the plasma membrane of mast cells by phosphorylation of the receptor for immunoglobulin E (IgE), FcεRI, by Lyn kinase…”
Get full text

A Nanocube Plasmonic Sensor for Molecular Binding on Membrane Surfaces by Galush, William J, Shelby, Sarah A, Mulvihill, Martin J, Tao, Andrea, Yang, Peidong, Groves, Jay T

“…Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. Here, silver nanocubes…”
Get full text

The membrane phase transition couples to protein scaffolds to produce functional organization at the cell surface by Shelby, Sarah A., Rouches, Mason, Machta, Benjamin B., Veatch, Sarah

Get full text

Probing membrane‐mediated forces between proteins in cells using super‐resolution fluorescence localization imaging by Veatch, Sarah L., Shelby, Sarah A.

“…Transmembrane and peripheral membrane proteins can interact directly via mechanisms common to soluble proteins, but also can feel forces mediated through their…”
Get full text

Functional Organization of Plasma Membrane Adaptor Proteins in B Cell Receptor Signaling by Shelby, Sarah A., Veatch, Sarah L.

Get full text

Membrane phase separation drives organization and activation at bcr signaling complexes by Shelby, Sarah A., Castello Serrano, Ivan, Wisser, Kathleen C., Levental, Ilya, Veatch, Sarah L.

Get full text

Testing a general mechanism for cluster-induced signaling in B cells by Flanagan, Jennifer C., Shelby, Sarah A., Stoddard, Andrea K., Veatch, Sarah L.

Get full text