Search Results - "Shelat, Harnath"

Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia by Madonna, Rosalinda, Taylor, Doris A., Geng, Yong-Jian, De Caterina, Raffaele, Shelat, Harnath, Perin, Emerson C., Willerson, James T.

“…RATIONALE:The number and function of stem cells decline with aging, reducing the ability of stem cells to contribute to endogenous repair processes. The repair…”
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MicroRNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis by Gao, Song, Wassler, Michael, Zhang, Lulu, Li, Yangxin, Wang, Jun, Zhang, Yi, Shelat, Harnath, Williams, Jason, Geng, Yong-Jian

“…Abstract Objective MicroRNA-133a (miR-133a) and insulin-like growth factor-1 (IGF-1) are two different molecules known to regulate cardiovascular cell…”
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IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1 by Li, Yangxin, Shelat, Harnath, Geng, Yong-Jian

“…► 3′-Untranslated regions of IGF-1 gene is a target of miR-1 in iPS cells. ► H2O2 increases miR-1 expression in iPS cells. ► IGF-1 prevents apoptosis of iPS…”
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Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function by Yuan, Guo-Qiang, Gao, Song, Geng, Yong-Jian, Tang, Yao-Ping, Zheng, Min-Juan, Shelat, Harnath, Collins, Scott, Wu, Han-Jing, Wu, Yi-Ling

“…Background： Our previous studies have shown that Tongxinluo （TXL）, a compound Chinese medicine, can decrease myocardial ischemia-reperfusion injury, protect…”
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High glucose-induced hyperosmolarity impacts proliferation, cytoskeleton remodeling and migration of human induced pluripotent stem cells via aquaporin-1 by Madonna, Rosalinda, Geng, Yong-Jian, Shelat, Harnath, Ferdinandy, Peter, De Caterina, Raffaele

“…Background and objective: Hyperglycemia leads to adaptive cell responses in part due to hyperosmolarity. In endothelial and epithelial cells, hyperosmolarity…”
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Rotating microgravity-bioreactor cultivation enhances the hepatic differentiation of mouse embryonic stem cells on biodegradable polymer scaffolds by Wang, Yingjie, Zhang, Yunping, Zhang, Shichang, Peng, Guangyong, Liu, Tao, Li, Yangxin, Xiang, Dedong, Wassler, Michael J, Shelat, Harnath S, Geng, Yongjian

“…Embryonic stem (ES) cells are pluripotent cells that are capable of differentiating all the somatic cell lineages, including those in the liver tissue. We…”
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Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation by Jiang, Xue-Yan, Feng, Yu-Liang, Ye, Li-Tong, Li, Xiao-Hong, Feng, Juan, Zhang, Meng-Zhen, Shelat, Harnath S., Wassler, Michael, Li, Yangxin, Geng, Yong-Jian, Yu, Xi-Yong

“…Maternal nicotine exposure causes alteration of gene expression and cardiovascular programming. The discovery of nicotine-medicated regulation in cardiogenesis…”
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Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics by KLEGERMAN, Melvin E, WASSLER, Michael, HUANG, Shao-Ling, YUEJIAO ZOU, KIM, Hyunggun, SHELAT, Harnath S, HOLLAND, Christy K, GENG, Yong-Jian, MCPHERSON, David D

“…Intrinsically echogenic liposomes (ELIP) can be adapted to encapsulate nitric oxide to facilitate ultrasound-enhanced delivery of therapeutic agents to…”
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Local Gene Transfer of Tissue Factor Pathway Inhibitor Regulates Intimal Hyperplasia in Atherosclerotic Arteries by Zoldhelyi, Pierre, Chen, Zhi-Qiang, Shelat, Harnath S., McNatt, Janice M., Willerson, James T.

“…Tissue factor (TF), the initiator of blood coagulation and thrombosis, is up-regulated after vascular injury and in atherosclerotic states. Systemic…”
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Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor by ZOLDHELYI, P, MCNATT, J, SHELAT, H. S, YAMAMOTO, Y, CHEN, Z.-Q, WILLERSON, J. T

“…Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of factor Xa and the coagulant initiator complex tissue factor/factor VIIa. To study the…”
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Abstract 12528: Intima Thickening, Adenosine Reduction and Calcification in CD73-Deficient Mice by Gao, Song, Mills, Tingting, Shelat, Harnath S, Geng, Yong-jian

“…Introduction and HypothesisThe 5' exonucleotidase, CD73, is a key enzyme for extracellular adenosine production. Mutations of the CD73 gene NT5E have been…”
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Adenoviral gene transfer of fortilin attenuates neointima formation through suppression of vascular smooth muscle cell proliferation and migration by TULIS, David A, MNJOYAN, Zakar H, SCHIESSER, Rachel L, SHELAT, Harnath S, EVANS, Alida J, ZOLDHELYI, Pierre, FUJISE, Ken

“…Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member…”
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Abstract 11422: Galactosyltransferase 1-Associating Protein Prevents Murine Vascular Runx2 Expression, Osteogenesis and Calcification by Gao, Song, Gao, Shanshan, Sun, Zhen, Akesson, Mikael, Shelat, Harnath S, Geng, Yong-jian

“…Introduction and HypothesisThe ubiquitin-conjugating enzyme, galactosyltransferase 1-associating protein (GTAP), is an E2 ubiquitin-conjugating enzyme…”
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Abstract 12993: Administration of Echogenic Immunoliposome-Targeted CD146+ Mesenchymal Stem Cells Reduces Hypercholesterolemia and Atherosclerosis by Geng, Yong-jian, Klegerman, Melvin E, Gao, Song, Shelat, Harnath S, McPherson, David D

“…Introduction and HypothesisMesenchymal stem cells (MSC) have been used to treat atherosclerosis and diabetes in animal studies and clinical trials. We…”
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Abstract 375: Assessment Of Ultrasound-facilitated Endothelial Permeability Using Transwell Culture Methodology by Islam, Afsana F, Peng, Tao, Shelat, Harnath S, Gao, Song, McPherson, David D, Geng, Yong-Jian, Klegerman, Melvin E

“…BackgroundWe have previously demonstrated the ability of continuous wave and pulsed Doppler ultrasound (US) to increase the permeability of the arterial wall…”
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Abstract 15904: Echogenic Immunoliposome-targeted Mesenchymal Stem Cells for Imaging and Treatment of Atheroma by Geng, Yong-jian, Klegerman, Melvin E, McPherson, David D, Gao, Song, Ghosh, Saurendro, Shelat, Harnath S, Gareeb, Mohammad

“…BackgroundVascular stem cell dead impairs the regenerating capacity of the arterial wall with atherosclerosis. A patented technology has been developed to…”
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Differential expression of microRNA and arachidonic acid metabolism in aspirin-treated human cardiac and peri-cardiac fat-derived mesenchymal stem cells by Ruan, Diana T., Gao, Song, Shelat, Harnath, King, Bridgette, Geng, Yong-Jian

“…Aspirin is a widely used drug with anti-coagulating and anti-inflammatory effects on atherosclerotic vascular disease. The goal of this study was to…”
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Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F-1 by SHELAT, Harnath S, LIU, Ta-Jen, HICKMAN-BICK, Diane L, BARNHART, Michael K, VIDA, Thomas, DILLARD, Patricia M, WILLERSON, James T, ZOLDHELYI, Pierre

“…The transcription factor E2F-1 promotes S-phase entry and death in transformed cells and primary cardiomyocytes. We tested the hypothesis that overexpression…”
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MicroRNA-322 inhibition of calcification of arterial smooth muscle cells by regulation of galactosyltransferase 1-associating protein UBE2Q1 and Runx2 by Gao, Shanshan, Gao, Song, Sun, Zhen, Akesson, Mikael, Shelat, Harnath S., Geng, Yongjian

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Reprogramming somatic cells to pluripotency: A fresh look at Yamanaka's model by Li, Yangxin, Shen, Zhenya, Shelat, Harnath, Geng, Yong-Jian

“…In 2006, Dr Shinya Yamanaka succeeded to reprogram somatic cells into pluripotent stem cells (iPSC) by delivering the genes encoding Oct4, Sox2, Klf4, and…”
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