Search Results - "Sheinin, Yuri M."

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer by Aithal, Abhijit, Junker, Wade M, Kshirsagar, Prakash, Das, Srustidhar, Kaur, Sukhwinder, Orzechowski, Catherine, Gautam, Shailendra Kumar, Jahan, Rahat, Sheinin, Yuri M, Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P, Batra, Surinder K, Jain, Maneesh

“…MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface…”
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Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program by Luan, Haitao, Mohapatra, Bhopal, Bielecki, Timothy A, Mushtaq, Insha, Mirza, Sameer, Jennings, Tameka A, Clubb, Robert J, An, Wei, Ahmed, Dena, El-Ansari, Rokaya, Storck, Matthew D, Mishra, Nitish K, Guda, Chittibabu, Sheinin, Yuri M, Meza, Jane L, Raja, Srikumar, Rakha, Emad A, Band, Vimla, Band, Hamid

“…CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer…”
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Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium by Hsu, Alice H., Lum, Michelle A., Shim, Kang-Sup, Frederick, Peter J., Morrison, Carl D., Chen, Baojiang, Lele, Subodh M., Sheinin, Yuri M., Daikoku, Takiko, Dey, Sudhansu K., Leone, Gustavo, Black, Adrian R., Black, Jennifer D.

“…Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating…”
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Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model by Peng, Zheng-Hong, Jogdeo, Chinmay M, Li, Jing, Xie, Ying, Wang, Yazhe, Sheinin, Yuri M, Kopeček, Jindřich, Oupický, David

“…Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting…”
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Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance by Krishn, Shiv Ram, Kaur, Sukhwinder, Sheinin, Yuri M, Smith, Lynette M, Gautam, Shailendra K, Patel, Asish, Jain, Maneesh, Juvvigunta, Vasthala, Pai, Priya, Lazenby, Audrey J, Roy, Hemant K, Batra, Surinder K

“…Sessile serrated adenoma/polyps (SSA/P) are premalignant lesions of colorectal cancer that are difficult to distinguish histologically from hyperplastic polyps…”
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B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis by Mansfield, Aaron Scott, Roden, Anja C, Peikert, Tobias, Sheinin, Yuri M, Harrington, Susan M, Krco, Christopher J, Dong, Haidong, Kwon, Eugene D

“…B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types…”
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Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation by Chugh, Seema, Meza, Jane, Sheinin, Yuri M, Ponnusamy, Moorthy P, Batra, Surinder K

“…Background: Aberrant glycosylation of several proteins underlie pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. O -glycosylation is…”
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PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling by Hein, Ashley L, Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Sheinin, Yuri M, Ouellette, Michel M, Ponnusamy, Moorthy P, Mumby, Marc C, Batra, Surinder K, Yan, Ying

“…The protein phosphatase 2 (PP2A) holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. Based on loss-of-function analysis…”
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Comparison of digital image analysis versus visual assessment to assess survivin expression as an independent predictor of survival for patients with clear cell renal cell carcinoma by Parker, Alexander S., PhD, Lohse, Christine M., MS, Leibovich, Bradley C., MD, Cheville, John C., MD, Sheinin, Yuri M., MD, PhD, Kwon, Eugene D., MD

“…Summary We previously used quantitative digital image analysis to report that high immunohistochemical tumor expression levels of survivin independently…”
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Rare and complicated functional posterior mediastinal paraganglioma by SenthilKumar, Gopika, Rokkas, Chris K, Sheinin, Yuri M, Linsky, Paul L

“…Functional mediastinal paragangliomas (PGs) are rare, catecholamine-secreting tumours. Surgical resection is the preferred treatment, but it can be complicated…”
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hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells by Karmakar, Saswati, Seshacharyulu, Parthasarathy, Lakshmanan, Imayavaramban, Vaz, Arokia P, Chugh, Seema, Sheinin, Yuri M, Mahapatra, Sidharth, Batra, Surinder K, Ponnusamy, Moorthy P

“…Cancer stem cells (CSCs), which mediate drug resistance and disease recurrence in several cancers, are therapeutically relevant to ovarian cancer (OC), wherein…”
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Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness by Felix, Juan C., Sheinin, Yuri M., Suster, David, Ronen, Natali, Ratiani, Mariam, Vanden Heuvel, Tana, Winge, Emilie, Patton, Mollie D., Rau, Mary J., Ge, Linna, Sun, Yunguang, Udhane, Sameer S., Langenheim, John F., Rui, Hallgeir

“…Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of…”
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MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer by Pai, Priya, Rachagani, Satyanarayana, Dhawan, Punita, Sheinin, Yuri M, Macha, Muzafar A, Qazi, Asif Khurshid, Chugh, Seema, Ponnusamy, Moorthy P, Mallya, Kavita, Pothuraju, Ramesh, Batra, Surinder K

“…MUC4 is a transmembrane mucin lining the normal colonic epithelium. The aberrant/de novo over-expression of MUC4 is well documented in malignancies of the…”
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RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment by Hein, A L, Post, C M, Sheinin, Y M, Lakshmanan, I, Natarajan, A, Enke, C A, Batra, S K, Ouellette, M M, Yan, Y

“…Radiation therapy is a staple approach for cancer treatment, whereas radioresistance of cancer cells remains a substantial clinical problem. In response to…”
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Hot Tub Lung: Case Report and Review of the Literature by Gundacker, Nathan D, Gonzalez, Jose Anel, Sheinin, Yuri M, Hirschtritt, Todd

“…INTRODUCTIONNontuberculous mycobacteria-related hypersensitivity pneumonitits (NTM-HP), otherwise known as hot tub lung, is an uncommon disease produced by…”
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Abstract 5762: PR55-alpha associated PP2A promotes pancreatic tumorigenesis by Yan, Ying, Hein, Ashley L., Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Sheinin, Yuri M., Ouellette, Michel M., Ponnusamy, Moorthy P., Batra, Surinder K.

“…PP2A holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. Loss of function analysis using PP2A catalytic inhibitors or…”
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