Search Results - "Sheils, Alissa L."

Structure of the Catalytic Domain of Human Polo-like Kinase 1 by Kothe, Michael, Kohls, Darcy, Low, Simon, Coli, Rocco, Cheng, Alan C, Jacques, Suzanne L, Johnson, Theresa L, Lewis, Cristina, Loh, Christine, Nonomiya, Jim, Sheils, Alissa L, Verdries, Kimberly A, Wynn, Thomas A, Kuhn, Cyrille, Ding, Yuan-Hua

“…Polo-like kinase 1 (Plk1) is an attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression…”
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A new chemical tool for exploring the physiological function of the PDE2 isozyme by Chambers, Robert J., Abrams, Kristin, Garceau, Norman Y., Kamath, Ajith V., Manley, Christopher M., Lilley, Susan C., Otte, Douglas A., Scott, Dennis O., Sheils, Alissa L., Tess, David A., Vellekoop, A. Samuel, Zhang, Yan, Lam, Kelvin T.

“…Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in…”
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Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and ¹H-¹⁵N TROSY Experiments by Stockman, Brian J, Kothe, Michael, Kohls, Darcy, Weibley, Laura, Connolly, Brendan J, Sheils, Alissa L, Cao, Qing, Cheng, Alan C, Yang, Lily, Kamath, Ajith V, Ding, Yuan-Hua, Charlton, Maura E

“…Aberrant activation of the phosphoinositide 3-kinase pathway because of genetic mutations of essential signalling proteins has been associated with human…”
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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function by Chambers, Robert J., Abrams, Kristin, Castleberry, Tessa A., Cheng, John B., Fisher, Douglas A., Kamath, Ajith V., Marfat, Anthony, Nettleton, David O., Pillar, Joann D., Salter, Eben D., Sheils, Alissa L., Shirley, John T., Turner, Claudia R., Umland, John P., Lam, Kelvin T.

“…Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis…”
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Identification of Allosteric PIF‐Pocket Ligands for PDK1 using NMR‐Based Fragment Screening and 1 H‐ 15 N TROSY Experiments by Stockman, Brian J., Kothe, Michael, Kohls, Darcy, Weibley, Laura, Connolly, Brendan J., Sheils, Alissa L., Cao, Qing, Cheng, Alan C., Yang, Lily, Kamath, Ajith V., Ding, Yuan‐Hua, Charlton, Maura E.

“…Aberrant activation of the phosphoinositide 3‐kinase pathway because of genetic mutations of essential signalling proteins has been associated with human…”
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