Search Results - "Sheikh, Saifuddin"

Lipid-based amphotericin B gel treatment eradicates vulvovaginal candidiasis in patients who failed to azole therapy by Sheikh, Saifuddin, Ahmad, Ateeq, Ali, Shoukath M., Paithankar, Mahesh, Patel, Ronak, Chuadhari, Shushil, Dave, Purvi M., Bhomia, Mamta V., Desai, Jagruti Y., Munshi, Atul, Shah, Meenakshi N., Desai, Kirankumar R., Dongre, Swati A., Walvekar, Shraddha A., Ahmad, Imran

“…Vaginal yeast infection is one of the most common diseases caused by vulvovaginal candidiasis (VVC). Effective therapy for VVC is needed. A lipid-based…”
Get full text

Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice by Chen, Paul, Sheikh, Saifuddin, Ahmad, Ateeq, Ali, Shoukath M, Ahmad, Moghis U, Ahmad, Imran

“…Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In…”
Get full text

Endoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder by Ali, Shoukath M., Ahmad, Ateeq, Shahabuddin, Syed, Ahmad, Moghis U., Sheikh, Saifuddin, Ahmad, Imran

“…A novel synthesis of endoxifen and its PKC inhibitory activity is reported. Protein kinase C (PKC) plays a major role in regulation of both pre and…”
Get full text

Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo by Chien, Pei-Yu, Wang, Jinkang, Carbonaro, Danielle, Lei, Sabrina, Miller, Bruce, Sheikh, Saifuddin, Ali, Shoukath M, Ahmad, Moghis U, Ahmad, Imran

“…Cationic liposomes have been successfully used as an alternative approach to viral systems to deliver nucleic acids. However, high toxicity and inconsistent…”
Get full text

Preclinical Safety, Pharmacokinetics and Antitumor Efficacy Profile of Liposome-entrapped SN-38 Formulation by PAL, Ajai, KHAN, Sumsullah, AHMAD, Imran, WANG, Yue-Fen, KAMATH, Narayan, SARKAR, Asis K, AHMAD, Ateeq, SHEIKH, Saifuddin, ALI, Shahid, CARBONARO, Danielle, ZHANG, Allen

“…Background: SN-38, 7-ethyl-10-hydroxycamptothecin, is a biologically active metabolite of irinotecan. Its poor solubility restricted its development as an…”
Get full text

Polyoxyl 60 hydrogenated castor oil free nanosomal formulation of immunosuppressant Tacrolimus: Pharmacokinetics, safety, and tolerability in rodents and humans by Ali, Shoukath M., Ahmad, Ateeq, Sheikh, Saifuddin, Ahmad, Moghis U., Rane, Rajendar C., Kale, Prashant, Paithankar, Mahesh, Saptarishi, Dipak, Sehgal, Ashish, Maheshwari, Kirti, Ahmad, Imran

“…Develop Nanosomal formulation of Tacrolimus to provide safer alternative treatment for organ transplantation patients. Investigate safety, tolerability and…”
Get full text

Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates by Ahmad, Moghis U., Ali, Shoukath M., Ahmad, Ateeq, Sheikh, Saifuddin, Chen, Paul, Ahmad, Imran

“…A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed…”
Get full text

Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002) by Ali, Shoukath M., Khan, Abdul R., Ahmad, Moghis U., Chen, Paul, Sheikh, Saifuddin, Ahmad, Imran

“…The synthesis and biological evaluation of novel gemcitabine–lipid conjugate is reported. A novel gemcitabine–lipid conjugate 5 was synthesized and tested for…”
Get full text

Involvement of Glutamate 399 and Lysine 192 in the Mechanism of Human Liver Mitochondrial Aldehyde Dehydrogenase by Ni, Li, Sheikh, Saifuddin, Weiner, Henry

“…Mutation to the conserved Glu399 or Lys192 caused the rate-limiting step of human liver mitochondrial aldehyde dehydrogenase (ALDH2) to change from deacylation…”
Get full text

The Potential Roles of the Conserved Amino Acids in Human Liver Mitochondrial Aldehyde Dehydrogenase by Sheikh, Saifuddin, Ni, Li, Hurley, Thomas D., Weiner, Henry

“…The sequence alignment of all known aldehyde dehydrogenases showed that only 23 residues were completely conserved (Hempel, J., Nicholas, H., and Lindahl, R…”
Get full text

Identification and Characterization of the Nudix Hydrolase from the Archaeon, Methanococcus jannaschii, as a Highly Specific ADP-ribose Pyrophosphatase by Sheikh, Saifuddin, O'Handley, Suzanne F., Dunn, Christopher A., Bessman, Maurice J.

“…The MJ1149 gene from the Archaeon,Methanococcus jannaschii, has been cloned and expressed inEscherichia coli. The 19-kDa protein containing the Nudix box,…”
Get full text

Induction chemotherapy with nanosomal docetaxel lipid suspension (NDLS), cisplatin, and fluorouracil in patients with locally advanced head and neck squamous cell carcinoma by Biswas, Ghanashyam, Ganta, Ranga Raman, N, Kharthik, Kantharia, Rajesh, Bondarde, Shailesh, Raghu Raman, Ramaiyer, Mahajan, Manoj, Ahmad, Ateeq, Sheikh, Saifuddin, Ali, Shoukath M, Paithankar, Mahesh, Patel, Lav, Rajani, Anil, Bunger, Deepak, Chaturvedi, Alok, Ahmad, Imran

“…6074 Background: Nanosomal docetaxel lipid suspension (NDLS), a polysorbate-80 and ethanol free formulation, was developed to overcome the toxicity issues and…”
Get full text

Safety and efficacy of nanosomal docetaxel lipid suspension (NDLS) in patients with advanced gastric adenocarcinoma by Ostwal, Vikas S., SHARMA, ATUL, Ghosh, Joydeep, Reddy, Rakesh, K, Lakshmi Priyadarshini, Srinivas, B. J., Raghu Raman, Ramaiyer, Kota, Rajesh, Panda, Soumya Surath, Agarwal, Amit, Seshachalam, Arun, Nemade, Bhushan Tapiram, Ahmad, Ateeq, Sheikh, Saifuddin, Ali, Shoukath M, Paithankar, Mahesh, Patel, Lav, Rajani, Anil, Bunger, Deepak, Ahmad, Imran

“…348 Background: Nanosomal docetaxel lipid suspension (NDLS) was developed to overcome toxicity issues associated with conventional docetaxel. Docetaxel,…”
Get full text

Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder by Ahmad, Ateeq, Sheikh, Saifuddin, Khan, Mujtaba Ali, Chaturvedi, Alok, Patel, Piyush, Patel, Ronak, Buch, Bakul Chandrakant, Anand, Rajendra Someshwar, Shah, Timirkumar Chandrakant, Vora, Vaishal Nareshchandra, Ramasubramanian, Vikhram, Rao, Satyanarayana, Kumar, Narendra, Prasad, B. S. V., Sathianathan, Ramanathan, Verma, Kamal Kumar, Jhanwar, Venu Gopal, Kumar, Nand, Shah, Sandip, Dalal, Pronob Kumar, Sindhu, Brahmdeep, Talukdar, Payel, Ahmad, Imran

“…Objectives Endoxifen is a protein kinase C inhibitor. The objective of the present phase III study was to demonstrate the safety and efficacy of endoxifen in…”
Get full text

Reply to Ghosh et al 1 . Comments on Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder by Ahmad, Ateeq, Sheikh, Saifuddin, Khan, Mujtaba Ali, Chaturvedi, Alok, Patel, Piyush, Patel, Ronak, Buch, Bakul Chandrakant, Anand, Rajendra Someshwar, Shah, Timirkumar Chandrakant, Vora, Vaishal Nareshchandra, Ramasubramanian, Vikhram, Rao, Satyanarayana, Kumar, Narendra, Prasad, B S V, Sathianathan, Ramanathan, Verma, Kamal Kumar, Jhanwar, Venu Gopal, Kumar, Nand, Shah, Sandip, Dalal, Pronob Kumar, Sindhu, Brahmdeep, Talukdar, Payel, Ahmad, Imran

Get full text

Reply to Ghosh et al1. Comments on Endoxifen: A new, protein kinase C inhibitor to treat acute and mixed mania associated with bipolar I disorder by Ahmad, Ateeq, Sheikh, Saifuddin, Khan, Mujtaba Ali, Chaturvedi, Alok, Patel, Piyush, Patel, Ronak, Buch, Bakul Chandrakant, Anand, Rajendra Someshwar, Shah, Timirkumar Chandrakant, Vora, Vaishal Nareshchandra, Ramasubramanian, Vikhram, Rao, Satyanarayana, Kumar, Narendra, Prasad, B. S. V., Sathianathan, Ramanathan, Verma, Kamal Kumar, Jhanwar, Venu Gopal, Kumar, Nand, Shah, Sandip, Dalal, Pronob Kumar, Sindhu, Brahmdeep, Talukdar, Payel, Ahmad, Imran

Get full text

Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients by Ali, Shoukath M, Chen, Paul, Sheikh, Saifuddin, Ahmad, Ateeq, Ahmad, Moghis, Paithankar, Mahesh, Desai, Brijesh, Patel, Piyush, Khan, Mujtaba, Chaturvedi, Alok, Patel, Ronak, Panchal, Dharmendra T, Shah, Kuntal, Chavda, Vipul, Saboo, Banshi D, Patel, Alpesh, Ahmad, Imran

“…Antihyperglycemic activity of Thymoquinone (TQ) was evaluated in diabetic mouse model and patients. TQ (50 mg/kg) was orally administered daily for 21 days in…”
Get more information

Orally administered Endoxifen is a new therapeutic agent for breast cancer by Ahmad, Ateeq, Ali, Shoukath M, Ahmad, Moghis U, Sheikh, Saifuddin, Ahmad, Imran

“…Endoxifen is the key active metabolite of Tamoxifen, a widely used breast cancer drug. Orally administered Tamoxifen, is extensively metabolized by cytochrome…”
Get full text

Treatment with nanosomal paclitaxel lipid suspension versus conventional paclitaxel in metastatic breast cancer patients - a multicenter, randomized, comparative, phase II/III clinical study by Satheesh, Chiradoni Thungappa, Taran, Rakesh, Singh, Jitendra Kumar, Shrivastav, Shanti Prakash, Vithalani, Nikunj K, Mukherjee, Kalyan Kusum, Nagarkar, Rajnish Vasant, Maksud, Tanveer, Mehta, Ajay Omprakash, Srinivasan, Krishnan, Vikranth, Mummaneni, Sonawane, Satish Ramkrishna, Ahmad, Ateeq, Sheikh, Saifuddin, Ali, Shoukath M, Patel, Ronak, Paithankar, Mahesh, Patel, Lav, Rajani, Anil, Bunger, Deepak, Chaturvedi, Alok, Ahmad, Imran

“…A novel nanosomal paclitaxel lipid suspension (NPLS), free from Cremophor EL (CrEL) and ethanol, was developed to address the solvent-related toxicities…”
Get full text

Detergent and alcohol free formulation of cabazitaxel: Safety and pharmacokinetics of escalating dose of cabazitaxel lipid suspension (CLS) in patients with advanced solid maliganancies by Ahmad, Ateeq, Sheikh, Saifuddin, Paithankar, Mahesh, Deshpande, Gururaj, Lakshmaiah, K.C., Maksud, Tanveer M, Khatri, Ajay, K, Manjunath, Kale, Prashant, Patel, Ronak, Barkate, Hanmant, Ahmad, Imran

“…Abstract only…”
Get full text