Search Results - "Sheikh, M. Saeed"

ECRG2/SPINK7 Tumor Suppressor as Modulator of DNA Damage Response by Patel, Harsh, Sheikh, M Saeed, Huang, Ying

“…Esophageal Cancer-Related Gene 2 ( ), also known as Serine Peptidase Inhibitor Kazal type 7 ( ), is a novel tumor suppressor gene from the family of genes that…”
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Antibody-drug Conjugates for Breast Cancer Treatment by Sheikh, M Saeed, Huang, Ying

“…The use of antibody-drug conjugates is expected to transform the management of human malignancy. Antibody-drug conjugates for cancer treatment are designed to…”
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ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage by Patel, Harsh, Sheikh, M. Saeed, Huang, Ying

“…Esophageal Cancer-Related Gene 2 (ECRG2) is a recently identified tumor suppressor, its regulation and involvement in DNA damage response are unknown. Here, we…”
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Uniform nomenclature for the mitochondrial contact site and cristae organizing system by Pfanner, Nikolaus, van der Laan, Martin, Amati, Paolo, Capaldi, Roderick A, Caudy, Amy A, Chacinska, Agnieszka, Darshi, Manjula, Deckers, Markus, Hoppins, Suzanne, Icho, Tateo, Jakobs, Stefan, Ji, Jianguo, Kozjak-Pavlovic, Vera, Meisinger, Chris, Odgren, Paul R, Park, Sang Ki, Rehling, Peter, Reichert, Andreas S, Sheikh, M Saeed, Taylor, Susan S, Tsuchida, Nobuo, van der Bliek, Alexander M, van der Klei, Ida J, Weissman, Jonathan S, Westermann, Benedikt, Zha, Jiping, Neupert, Walter, Nunnari, Jodi

“…The mitochondrial inner membrane contains a large protein complex that functions in inner membrane organization and formation of membrane contact sites. The…”
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Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein by Liu, Renyan, Wang, Xin, Curtiss, Christopher, Sheikh, M. Saeed, Huang, Ying

“…We have previously reported that Monoglyceride Lipase (MGL) expression is absent or reduced in various human malignancies and MGL-deficient mice develop tumors…”
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CHCM1/CHCHD6, Novel Mitochondrial Protein Linked to Regulation of Mitofilin and Mitochondrial Cristae Morphology by An, Jie, Shi, Jingxue, He, Qin, Lui, Ki, Liu, Yuxin, Huang, Ying, Sheikh, M. Saeed

“…The structural integrity of mitochondrial cristae is crucial for mitochondrial functions; however, the molecular events controlling the structural integrity…”
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CHTM1, a novel metabolic marker deregulated in human malignancies by Babbar, Mansi, Huang, Ying, An, Jie, Landas, Steve K., Sheikh, M. Saeed

“…A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named…”
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Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma by Liu, Renyan, Wang, Xin, Curtiss, Christopher, Landas, Steve, Rong, Rong, Sheikh, M. Saeed, Huang, Ying

“…Monoglyceride lipase (MGL) is a recently discovered cancer-related protein. The role of MGL in tumorigenesis remains to be fully elucidated. We have previously…”
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Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L by Sun, Qing, Liu, Kanglun, Shen, Xiaoling, Jin, Weixin, Jiang, Lingyan, Sheikh, M Saeed, Hu, Yingjie, Huang, Ying

“…In an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, Lappaol F, from plant Arctium Lappa L. Lappaol F…”
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CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway by Babbar, Mansi, Huang, Ying, Curtiss, Christopher M, Sheikh, M Saeed

“…Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and…”
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Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion by Babbar, Mansi, Sheikh, M Saeed

“…Mitochondrial morphology and metabolism play an important role in cellular homeostasis. Recent studies have shown that the fidelity of mitochondrial morphology…”
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Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L TRAIL to induce apoptosis in Bax-proficient and -deficient cells by QIN HE, YING HUANG, SAEED SHEIKH, M

“…Apo2L/TRAIL (tumor necrosis factor-related apoptosis inducing ligand (TRAIL), also known as Apo2L) is a potentially important anticancer agent awaiting…”
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Regulation of p53 oligomerization by Ras superfamily protein RBEL1A by Lui, Ki, Sheikh, M Saeed, Huang, Ying

“…Our previous studies showed that RBEL1A overexpressed in multiple human malignancies and its depletion by RNAi caused severe growth inhibition in tumor cells…”
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Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest by RONG RONG, WEIXIN JIN, ZHANG, Jennifer, SHEIKH, M. Saeed, YING HUANG

“…RASSF1A is a putative tumor suppressor gene that is inactivated in a variety of human tumors. Expression of exogenous RASSF1A has been shown to inhibit tumor…”
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Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells by He, Qin, Shi, Jingxue, Shen, Xiao-Ling, An, Jie, Sun, Hong, Wang, Lu, Hu, Ying-Jie, Sun, Qing, Fu, Lin-Chun, Sheikh, M. Saeed, Huang, Ying

“…Dihydroartemisinin (DHA) is a derivative of artemisinin and is an effective anti-malaria therapeutic used worldwide. In this report, we report that DHA is as a…”
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Death Receptor Activation Complexes: It Takes Two to Activate TNF Receptor 1 by Sheikh, M. Saeed, Huang, Ying

“…The extrinsic pathway of apoptosis originates at the membrane and engages membrane death receptors. Tumor necrosis factor receptor 1 (TNF-R1) is a death…”
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Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation by Jiang, Lingyan, Rong, Rong, Sheikh, M Saeed, Huang, Ying

“…The tumor suppressor RAS-association domain family 1 isoform A (RASSF1A) is known to play an important role in cell-cycle regulation. However, the molecular…”
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Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis by CORCORAN, Chad A, QIN HE, YING HUANG, SAEED SHEIKH, M

“…Cyclooxygenase-2 (COX-2) has been implicated in a variety of human malignancies and, accordingly, COX-2 selective inhibitors are being investigated as…”
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Identification and Characterization of RBEL1 Subfamily of GTPases in the Ras Superfamily Involved in Cell Growth Regulation by Montalbano, JoAnne, Lui, Ki, Sheikh, M. Saeed, Huang, Ying

“…Recently, we reported the identification of a novel gene named RBEL1 (Rab-like protein 1) and characterized its two encoded isoforms, RBEL1A and RBEL1B, that…”
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DOC45, a Novel DNA Damage–Regulated Nucleocytoplasmic ATPase That Is Overexpressed in Multiple Human Malignancies by Sun, Hong, Luo, Xiuquan, Montalbano, JoAnne, Jin, Weixin, Shi, Jingxue, Sheikh, M Saeed, Huang, Ying

“…In this article, we report the characterization of a novel DNA damage–regulated gene, named DNA damage–regulated overexpressed in cancer 45 ( DOC45 ). Our…”
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