Is renal medullary carcinoma the seventh nephropathy in sickle cell disease? A multi-center Nigerian survey

Is renal medullary carcinoma the seventh nephropathy in sickle cell disease? A multi-center Nigerian survey

Introduction: Previous studies had enlisted renal medullary carcinoma (RMC) as the seventh nephropathy in sickle cell disease (SCD). Clinical experience has contradicted this claim and this study is targeted at refuting or supporting this assumption. Objective: To estimate the prevalence of RMC and...

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Published in:African health sciences Vol. 16; no. 2; pp. 490 - 496
Main Authors: Madu,Anazoeze, Najibah, Galadincci, Garba, Umar, Shehu, Abdulahi, Florence, Fowodu, Abdulaziz, Hassan, Marcus, Inyama, Oluwaseun, Akinpelu, Theresa, Nwagha, Obike, Ibegbulam, Sunday, Ocheni, Ifeoma, Korubo, Uche, Anike, Kingsley,Agu, Charles,Nonyelu, Angela,Ugwu, Augustin,Duru, Chikwudi, Anigbo, Alozie, Eze, Uchenna,Ololo, Caroline,Omoti, Obineche,Agwu, Iheanyi,Okpala
Format: Journal Article
Language:English
Published: Uganda Makerere University Medical School 01-06-2016
Makerere Medical School
Subjects:
Adult
Age Distribution
Anemia, Sickle Cell - diagnosis
Anemia, Sickle Cell - epidemiology
Anemia, Sickle Cell - therapy
Cancer
Carcinoma, Medullary - diagnosis
Carcinoma, Medullary - epidemiology
Carcinoma, Medullary - therapy
Comorbidity
Cross-Sectional Studies
Developing Countries
Female
Humans
Kidney diseases
Kidney Neoplasms - diagnosis
Kidney Neoplasms - epidemiology
Kidney Neoplasms - therapy
Male
Medical Screening
Middle Aged
Monitoring, Physiologic
Nigeria - epidemiology
Nigerian survey
Patients
Prevalence
Prognosis
Registries
Renal medullary carcinoma
Research methodology
Risk Assessment
seventh nephropathy
Sex Distribution
Sickle cell anemia
sickle cell disease
Statistical analysis
Survival Analysis
Nigeria
seventh nephropathy
Renal medullary carcinoma
Nigerian survey
sickle cell disease
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Summary:Introduction: Previous studies had enlisted renal medullary carcinoma (RMC) as the seventh nephropathy in sickle cell disease (SCD). Clinical experience has contradicted this claim and this study is targeted at refuting or supporting this assumption. Objective: To estimate the prevalence of RMC and describe other renal complications in SCD. Materials and methods: 14 physicians (haematologists and urologists) in 11 tertiary institutions across the country were collated from patients' case notes and hospital SCD registers. Results: Of the 3,596 registered sickle patients, 2 (0.056%) had been diagnosed with RMC over a ten year period, thereby giving an estimated prevalence rate of 5.6 per 100,000. The most common renal complication reported by the attending physicians was chronic kidney disease (CKD). The frequency of routine renal screening for SCD patients varied widely between centres - most were done at diagnosis, annually or bi-annually. Conclusion: The ten year prevalence of RMC in Nigerian SCD patients was determined to be 5.6 (estimated incidence of 0.56). RMC is not more common in SCD patients and therefore cannot be regarded as a "Seventh Sickle nephropathy". Most of the managing physicians reported that the commonest nephropathy observed in their SCD patients was chronic kidney disease.
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ISSN:1680-6905
1729-0503
1680-6905
DOI:10.4314/ahs.v16i2.17