Search Results - "Sheetz, M J"

Sustained moderate visual loss as a predictive end point for visual loss in non-proliferative diabetic retinopathy by Girach, A, Aiello, L P, Milton, R C, Davis, M D, Danis, R P, Zhi, X, Sheetz, M J, Vignati, L

“…Purpose In PKC-DRS2, the efficacy of the oral PKC- β inhibitor, ruboxistaurin 32 mg/day, was measured by the primary end point of sustained moderate visual…”
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Estimated glomerular filtration rate progression in UK primary care patients with type 2 diabetes and diabetic kidney disease: a retrospective cohort study by Cid Ruzafa, J, Paczkowski, R, Boye, K S, Di Tanna, G L, Sheetz, M J, Donaldson, R, Breyer, M D, Neasham, D, Voelker, J R

“…To examine the rates of diabetic kidney disease (DKD) progression and associated factors, we undertook a study of estimated glomerular filtration rate (eGFR)…”
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Splenomegaly in dogs: predictors of neoplasia and survival after splenectomy by Johnson, K.A. (University of Sydney, Sydney, NSW, Australia), Powers, B.E, Withrow, S.J, Sheetz, M.J, Curtis, C.R, Wrigley, R.H

“…Splenomegaly confirmed by surgery or necropsy in 100 dogs was diagnosed histologically as benign neoplasia (n = 1), primary splenic malignancy (n = 59),…”
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Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing by Sheetz, M J, Tager, H S

“…Previous studies have identified the association of the hepatic glucagon receptor with a membrane-bound protease which cleaves [[125I]iodo-Tyr10]glucagon in a…”
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Receptor-linked proteolysis of membrane-bound glucagon yields a membrane-associated hormone fragment by Sheetz, M J, Tager, H S

“…We have studied, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography, glucagon-receptor complexes that arise from the incubation…”
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MDL 29311, a phenolic antioxidant, interferes with the interaction of apoC with VLDL: a possible explanation for its triglyceride-lowering effect by Sheetz, M.J.

“…MDL 29311 is an antioxidant that lowers plasma triglycerides and raises high density lipoprotein (HDL) cholesterol in rats. It lowers triglycerides in rats by…”
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Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications by Sheetz, Matthew J, King, George L

“…Diabetic complications are the major cause of morbidity and mortality in persons with diabetes. Chronic hyperglycemia is a major initiator of diabetic…”
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MDL 29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice by Johnson, M. B., Heineke, E. W., Rhinehart, B. L., Sheetz, M. J., Barnhart, R. L., Robinson, K. M.

“…MDL 29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice. M B Johnson , E W Heineke , B L Rhinehart , M J Sheetz , R L…”
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MDL 29311 : antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice by JOHNSON, M. B, HEINEKE, E. W, RHINEHART, B. L, SHEETZ, M. J, BARNHART, R. L, ROBINSON, K. M

“…MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX…”
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MDL 29311, an analog of probucol, decreases triglycerides in rats by increasing hepatic clearance of very-low-density lipoprotein by Sheetz, M J, Barnhart, R L, Jackson, R L, Robinson, K M

“…MDL 29311 is an analog of probucol that shares probucol's antioxidant and antiatherogenic properties. When fed to rats as a 1% dietary admixture, MDL 29311…”
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Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes- induced retinal hemodynamic abnormalities in patients by AIELLO, Lloyd Paul, CLERMONT, Alien, ARORA, Vipin, DAVIS, Matthew D, SHEETZ, Matthew J, BURSELL, Sven-Eric

“…To assess ocular and systemic safety and pharmacodynamic effects of the oral PKC beta selective inhibitor ruboxistaurin (RBX; LY333531) mesylate in patients…”
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Splenomegaly in Dogs by Johnson, K. A., Powers, B. E., Withrow, S. J., Sheetz, M. J., Curtis, C. R., Wrigley, R. H.

“…Splenomegaly confirmed by surgery or necropsy in 100 dogs was diagnosed histologically as benign neoplasia (n = 1), primary splenic malignancy (n = 59),…”
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The role of protein kinase C in the development of the complications of diabetes by Ways, D.Kirk, Sheetz, Matthew J.

“…Diabetes mellitus produces a state of chronic hyperglycemia which in turn leads to the development of severe complications including retinopathy, nephropathy,…”
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Receptor-linked proteolysis of membrane-bound glucagon yiedls a membrane-associated hormone fragment by SHEETZ, M. J, TAGER, H. S

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