Search Results - "Sheehy, Ryan M"
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Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification
Published in Molecular pharmacology (01-07-2012)“…Schweinfurthins are potent inhibitors of cancer cell growth, especially against human central nervous system tumor lines such as SF-295 cells. However, the…”
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RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth
Published in The Journal of clinical investigation (01-04-2019)“…Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically, but tumor…”
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A retrospective and correlative analysis of academic and nonacademic predictors of COMLEX level 1 performance
Published in Journal of Osteopathic Medicine (Online) (27-01-2022)“…National licensing exams (NLEs) including the Comprehensive Osteopathic Medical Licensing Examination (COMLEX) Level 1 evaluate student achievement. Scores…”
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Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil
Published in Cancer biology & therapy (2015)“…Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether…”
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Abstract 811: Schweinfurthin activity enhanced by verapamil
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Schweinfurthins are intriguing natural product anti-cancer agents with incompletely defined mechanisms of action. Schweinfurthins increase ER stress…”
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