Search Results - "Sheehan, D M"

The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands by Blair, Robert M., Fang, Hong, Branham, William S., Hass, Bruce S., Dial, Stacey L., Moland, Carrie L., Tong, Weida, Shi, Leming, Perkins, Roger, Sheehan, Daniel M.

“…We have utilized a validated (standardized) estrogen receptor (ER) competitive-binding assay to determine the ER affinity for a large, structurally diverse…”
Get full text

Structure−Activity Relationships for a Large Diverse Set of Natural, Synthetic, and Environmental Estrogens by Fang, Hong, Tong, Weida, Shi, Leming M, Blair, Robert, Perkins, Roger, Branham, William, Hass, Bruce S, Xie, Qian, Dial, Stacy L, Moland, Carrie L, Sheehan, Daniel M

“…Understanding structural requirements for a chemical to exhibit estrogen receptor (ER) binding has been important in various fields. This knowledge has been…”
Get full text

Research Needs for the Risk Assessment of Health and Environmental Effects of Endocrine Disruptors: A Report of the U.S. EPA-Sponsored Workshop by Kavlock, Robert J., Daston, George P., DeRosa, Chris, Fenner-Crisp, Penny, Gray, L. Earl, Kaattari, Steve, Lucier, George, Luster, Michael, Mac, Michael J., Maczka, Carol, Miller, Ron, Moore, Jack, Rolland, Rosalind, Scott, Geoffrey, Sheehan, Daniel M., Sinks, Thomas, Tilson, Hugh A.

“…The hypothesis has been put forward that humans and wildlife species have suffered adverse health effects after exposure to endocrine-disrupting chemicals…”
Get full text

Comparative molecular field analysis (CoMFA) model using a large diverse set of natural, synthetic and environmental chemicals for binding to the androgen receptor by Hong, H., Fang, H., Xie, Q., Perkins, R., Sheehan, D. M., Tong, W.

“…A large number of natural, synthetic and environmental chemicals are capable of disrupting the endocrine systems of experimental animals, wildlife and humans…”
Get full text

Herbal medicines, phytoestrogens and toxicity: risk:benefit considerations by Sheehan, D M

“…There are several suggested health benefits of phytoestrogens, particularly those found in soy products. Herbal medicines are also widely thought to confer…”
Get more information

QSAR models for binding of estrogenic compounds to estrogen receptor alpha and beta subtypes by Tong, W, Perkins, R, Xing, L, Welsh, W J, Sheehan, D M

“…We have developed Quantitative Structure-Activity Relationship (QSAR) models based on Comparative Molecular Field Analysis (CoMFA) for 31 estrogenic chemicals…”
Get full text

Prenatal dexamethasone or stress but not ACTH or corticosterone alter sexual behavior in male rats by Holson, R.R., Gough, B., Sullivan, P., Badger, T., Sheehan, D.M.

“…Prenatal maternal stress in rats and mice can demasculinize and feminize the sexual behavior of adult male offspring. Causal mechanisms are unknown, but one…”
Get full text

Ovarian and adrenal contributions to postnatal growth and differentiation of the rat uterus by BRANHAM, W. S, SHEEHAN, D. M

“…We tested the hypothesis that ovarian and/or adrenal factors contribute to uterine growth, differentiation, and acquisition of estrogen responsiveness in the…”
Get full text

Regulatory application of SAR/QSAR for priority setting of endocrine disruptors: A perspective by Tong, W., Fang, Hong, Hong, H., Xie, Q., Perkins, R., Anson, Jeanne, Sheehan, D. M.

“…Some seven years have passed since the U.S. legislature mandated the EPA to develop and implement a screening and testing program for chemicals that may…”
Get full text

Quantitative Comparisons of in Vitro Assays for Estrogenic Activities by Fang, Hong, Tong, Weida, Perkins, Roger, Soto, Ana M., Prechtl, Nancy V., Sheehan, Daniel M.

“…Substances that may act as estrogens show a broad chemical structural diversity. To thoroughly address the question of possible adverse estrogenic effects,…”
Get full text

Tissue-Specific Expression of Messenger Ribonucleic Acids for Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins during Perinatal Development of the Rat Uterus by GU, Y, BRANHAM, W. S, SHEEHAN, D. M, WEBB, P. J, MOLAND, C. L, STRECK, R. D

“…Insulin-like growth factor (IGF)-I and IGF-II play a number of important roles in growth and differentiation, and IGF-binding proteins (IGFBPs) modulate IGF…”
Get full text

Differential sensitivity of rat uterine growth and epithelium hypertrophy to estrogens and antiestrogens by Branham, W S, Zehr, D R, Sheehan, D M

“…Triphenylethylene antiestrogens are considered weak estrogen agonists based on their limited ability to induce estrogen responses, in particular uterine…”
Get more information

Quantitative Structure-Activity Relationships (QSARs) for Estrogen Binding to the Estrogen Receptor: Predictions across Species by Tong, Weida, Perkins, Roger, Strelitz, Richard, Collantes, Elizabeth R., Keenan, Susan, Welsh, William J., Branham, William S., Sheehan, Daniel M.

“…The recognition of adverse effects due to environmental endocrine disruptors in humans and wildlife has focused attention on the need for predictive tools to…”
Get full text

An integrated "4-phase" approach for setting endocrine disruption screening priorities--phase I and II predictions of estrogen receptor binding affinity by Shi‡, L., Tong, W., Fang, H., Xie, Q., Hong, H., Perkins, R., Wu, J., Tu§, M., Blair, R.M, Branham, W.S, Waller, C., Walker, J., Sheehan, D.M.

“…Recent legislation mandates the US Environmental Protection Agency (EPA) to develop a screening and testing program for potential endocrine disrupting…”
Get full text

Study of 202 Natural, Synthetic, and Environmental Chemicals for Binding to the Androgen Receptor by Fang, Hong, Tong, Weida, Branham, William S, Moland, Carrie L, Dial, Stacy L, Hong, Huixiao, Xie, Qian, Perkins, Roger, Owens, William, Sheehan, Daniel M

“…A number of environmental and industrial chemicals are reported to possess androgenic or antiandrogenic activities. These androgenic endocrine disrupting…”
Get full text

The effects of phytoestrogens on neonatal rat uterine growth and development by Medlock, K L, Branham, W S, Sheehan, D M

“…Phytoestrogens found in clover, alfalfa, and soybeans have caused reproductive toxicity in several mammalian species. Other estrogens, such as…”
Get more information

Effects of coumestrol and equol on the developing reproductive tract of the rat by Medlock, K L, Branham, W S, Sheehan, D M

“…The phytoestrogens, coumestrol and equol, are weakly estrogenic. Here, we have examined their ability to induce responses in the neonatal rat uterus. Potent…”
Get more information

Ontogeny of estrogen receptor messenger ribonucleic acid expression in the postnatal rat uterus by FISHMAN, R. B, BRANHAM, W. S, STRECK, R. D, SHEEHAN, D. M

“…During the first 2 wk of postnatal life, the rodent uterus undergoes a period of marked growth and differentiation. To further examine the role of the estrogen…”
Get full text

Effects of toremifene on neonatal rat uterine growth and differentiation by MEDLOCK, K. L, BRANHAM, W. S, SHEEHAN, D. M

“…In the developing rodent uterus, the estrogen agonist activity of triphenylethylene antiestrogens such as tamoxifen alters uterine luminal epithelium…”
Get full text

No-threshold dose–response curves for nongenotoxic chemicals: Findings and applications for risk assessment by Sheehan, Daniel M.

“…We tested the hypothesis that no threshold exists when estradiol acts through the same mechanism as an active endogenous estrogen. A Michaelis–Menten (MM)…”
Get full text