Search Results - "Shearn, Jason T"

The Role of Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair by Galloway, Marc T, Lalley, Andrea L, Shearn, Jason T

“…➤ Tendon injuries often result from excessive or insufficient mechanical loading, impairing the ability of the local tendon cell population to maintain normal…”
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The paratenon contributes to scleraxis-expressing cells during patellar tendon healing by Dyment, Nathaniel A, Liu, Chia-Feng, Kazemi, Namdar, Aschbacher-Smith, Lindsey E, Kenter, Keith, Breidenbach, Andrew P, Shearn, Jason T, Wylie, Christopher, Rowe, David W, Butler, David L

“…The origin of cells that contribute to tendon healing, specifically extrinsic epitenon/paratenon cells vs. internal tendon fibroblasts, is still debated. The…”
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Knee Abduction Affects Greater Magnitude of Change in ACL and MCL Strains Than Matched Internal Tibial Rotation In Vitro by Bates, Nathaniel A., Nesbitt, Rebecca J., Shearn, Jason T., Myer, Gregory D., Hewett, Timothy E.

“…Background Anterior cruciate ligament (ACL) injures incur over USD 2 billion in annual medical costs and prevention has become a topic of interest in…”
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Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation by Butler, David L., Juncosa-Melvin, Natalia, Boivin, Gregory P., Galloway, Marc T., Shearn, Jason T., Gooch, Cynthia, Awad, Hani

“…Over the past 8 years, our group has been continuously improving tendon repair using a functional tissue engineering (FTE) paradigm. This paradigm was…”
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Murine patellar tendon biomechanical properties and regional strain patterns during natural tendon-to-bone healing after acute injury by Gilday, Steven D, Chris Casstevens, E, Kenter, Keith, Shearn, Jason T, Butler, David L

“…Abstract Tendon-to-bone healing following acute injury is generally poor and often fails to restore normal tendon biomechanical properties. In recent years,…”
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The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full-length injury in the murine patellar tendon by Dyment, Nathaniel A., Kazemi, Namdar, Aschbacher-Smith, Lindsey E., Barthelery, Nicolas J., Kenter, Keith, Gooch, Cynthia, Shearn, Jason T., Wylie, Christopher, Butler, David L.

“…Tendon injuries are major orthopedic problems that worsen as the population ages. Type‐I (Col1) and type‐II (Col2) collagens play important roles in tendon…”
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Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct by Nirmalanandhan, Victor S, Rao, Marepalli, Shearn, Jason T, Juncosa-Melvin, Natalia, Gooch, Cindi, Butler, David L

“…Abstract Introducing mesenchymal stem cell (MSC)-seeded collagen constructs into load-protected wound sites in the rabbit patellar and Achilles tendons…”
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Mechanical stimulation of tissue engineered tendon constructs: effect of scaffold materials by Nirmalanandhan, Victor S, Dressler, Matthew R, Shearn, Jason T, Juncosa-Melvin, Natalia, Rao, Marepalli, Gooch, Cynthia, Bradica, Gino, Butler, David L

“…Our group has shown that numerous factors can influence how tissue engineered tendon constructs respond to in vitro mechanical stimulation. Although one study…”
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Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus by Nirmalanandhan, Victor S, Shearn, Jason T, Juncosa-Melvin, Natalia, Rao, Marepalli, Gooch, Cynthia, Jain, Abhishek, Bradica, Gino, Butler, David L

“…In vitro mechanical stimulation has been reported to induce cell alignment and increase cellular proliferation and collagen synthesis. Our group has previously…”
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Determine the vertical ground reaction forces and knee mechanics with different gait inclinations in the sheep model by Spatholt, Rebecca J., Minoughan, Chelsea E., Gooch, Cynthia, Harms, Samuel P., Taylor, Michal L., Galloway, Marc T., Shearn, Jason T.

“…Our current understanding of knee mechanics and anterior cruciate ligament (ACL) function is predominately based on data recorded during simulations of…”
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Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: A systematic review and meta-analysis by Bates, Nathaniel A, Myer, Gregory D, Shearn, Jason T, Hewett, Timothy E

“…Abstract Investigators use in vitro joint simulations to invasively study the biomechanical behaviors of the anterior cruciate ligament. The aims of these…”
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Relative Strain in the Anterior Cruciate Ligament and Medial Collateral Ligament During Simulated Jump Landing and Sidestep Cutting Tasks: Implications for Injury Risk by Bates, Nathaniel A., Nesbitt, Rebecca J., Shearn, Jason T., Myer, Gregory D., Hewett, Timothy E.

“…Background: The medial collateral (MCL) and anterior cruciate ligaments (ACL) are, respectively, the primary and secondary ligamentous restraints against knee…”
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Posterior Tibial Slope Angle Correlates With Peak Sagittal and Frontal Plane Knee Joint Loading During Robotic Simulations of Athletic Tasks by Bates, Nathaniel A., Nesbitt, Rebecca J., Shearn, Jason T., Myer, Gregory D., Hewett, Timothy E.

“…Background: Tibial slope angle is a nonmodifiable risk factor for anterior cruciate ligament (ACL) injury. However, the mechanical role of varying tibial…”
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Fibrin gels exhibit improved biological, structural, and mechanical properties compared with collagen gels in cell-based tendon tissue-engineered constructs by Breidenbach, Andrew P, Dyment, Nathaniel A, Lu, Yinhui, Rao, Marepalli, Shearn, Jason T, Rowe, David W, Kadler, Karl E, Butler, David L

“…The prevalence of tendon and ligament injuries and inadequacies of current treatments is driving the need for alternative strategies such as tissue…”
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Functional tissue engineering of tendon: Establishing biological success criteria for improving tendon repair by Breidenbach, Andrew P, Gilday, Steven D, Lalley, Andrea L, Dyment, Nathaniel A, Gooch, Cynthia, Shearn, Jason T, Butler, David L

“…Abstract Improving tendon repair using Functional Tissue Engineering (FTE) principles has been the focus of our laboratory over the last decade. Although our…”
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Sex-Based Differences in Knee Ligament Biomechanics During Robotically Simulated Athletic Tasks by Bates, Nathaniel A, Nesbitt, Rebecca J, Shearn, Jason T, Myer, Gregory D, Hewett, Timothy E

“…Abstract ACL injury rates are greater in female athletes than their male counterparts. As female athletes are at increased risk, it is important to understand…”
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Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury by Lalley, Andrea L., Dyment, Nathaniel A., Kazemi, Namdar, Kenter, Keith, Gooch, Cynthia, Rowe, David W., Butler, David L., Shearn, Jason T.

“…ABSTRACT Musculoskeletal injuries greatly affect the U.S. population and current clinical approaches fail to restore long‐term native tissue structure and…”
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Effects of Population Variability on Knee Loading During Simulated Human Gait by Nesbitt, Rebecca J., Bates, Nathaniel A., Rao, Marepalli B., Schaffner, Grant, Shearn, Jason T.

“…Cadaveric simulation models allow researchers to study native tissues in situ . However, as tests are conducted using donor specimens with unmatched…”
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Primary and secondary restraints of human and ovine knees for simulated in vivo gait kinematics by Nesbitt, Rebecca J, Herfat, Safa T, Boguszewski, Daniel V, Engel, Andrew J, Galloway, Marc T, Shearn, Jason T

“…Abstract Knee soft tissue structures are frequently injured, leading to the development of osteoarthritis even with treatment. Understanding how these…”
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A Novel Methodology for the Simulation of Athletic Tasks on Cadaveric Knee Joints with Respect to In Vivo Kinematics by Bates, Nathaniel A., Nesbitt, Rebecca J., Shearn, Jason T., Myer, Gregory D., Hewett, Timothy E.

“…Six degree of freedom (6-DOF) robotic manipulators have simulated clinical tests and gait on cadaveric knees to examine knee biomechanics. However, these…”
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