Search Results - "Shearer, TR"

Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes by Nakajima, Emi, Nakajima, Takeshi, Minagawa, Yoko, Shearer, Thomas R, Azuma, Mitsuyoshi

“…Aqueous outflow in the conventional outflow pathway is regulated by the contraction and relaxation of the ciliary muscle (CM) and the trabecular meshwork (TM)…”
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Evidence that an Isoform of Calpain-10 Is a Regulator of Exocytosis in Pancreatic β-Cells by Marshall, Catriona, Hitman, Graham A, Partridge, Christopher J, Clark, Anne, Ma, Hong, Shearer, Thomas R, Turner, Mark D

“…Calpain-10 (CAPN10) is the first type 2 diabetes susceptibility gene to be identified through a genome scan, with polymorphisms being associated with altered…”
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Minerals in the hair and nutrient intake of autistic children by Shearer, T R, Larson, K, Neuschwander, J, Gedney, B

“…The concentrations of calcium, magnesium, zinc, copper, lead, and cadmium were determined in scalp hair samples from a group of 12 autistic children and a…”
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Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia by Tamada, Yoshiyuki, Nakajima, Emi, Nakajima, Takeshi, Shearer, Thomas R., Azuma, Mitsuyoshi

“…Our previous studies in retina on the mechanism for hypoxia-induced cell death suggested activation of a class of calcium-activated proteases known as…”
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Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization by Ma, H, Fukiage, C, Kim, Y H, Duncan, M K, Reed, N A, Shih, M, Azuma, M, Shearer, T R

“…Calpains are calcium-dependent intracellular nonlysosomal proteases that are believed to hydrolyze specific substrates important in calcium-regulated signaling…”
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Lens Proteomics: Analysis of Rat Crystallin Sequences and Two-Dimensional Electrophoresis Map by Lampi, Kirsten J, Shih, Marjorie, Ueda, Yoji, Shearer, Thomas R, David, Larry L

“…To determine the sequence of four rat beta-crystallins, confirm the sequences by mass spectrometry, and produce a two-dimensional electrophoresis (2-DE) map of…”
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Deamidation, but Not Truncation, Decreases the Urea Stability of a Lens Structural Protein, βB1-Crystallin by Kim, Yung Hae, Kapfer, Deborah M, Boekhorst, Jos, Lubsen, Nicolette H, Bächinger, Hans Peter, Shearer, Thomas R, David, Larry L, Feix, Jimmy B, Lampi, Kirsten J

“…Crystallins, the major structural proteins in the lens of the eye, are maintained with little turnover throughout the lifetime of the host. With time, lens…”
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Calpain May Contribute to Hereditary Cataract Formation in Sheep by Robertson, Lucinda J. G, Morton, James D, Yamaguchi, Masazumi, Bickerstaffe, Roy, Shearer, Thomas R, Azuma, Mitsuyoshi

“…To determine the involvement of calpain in ovine cataractogenesis by measuring calcium, calpain activity, proteolysis, and the effect of calpain inhibition…”
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Sequence Analysis of βA3, βB3, and βA4 Crystallins Completes the Identification of the Major Proteins in Young Human Lens by Lampi, Kirsten J., Ma, Zhixiang, Shih, Marjorie, Shearer, Thomas R., Smith, Jean B., Smith, David L., David, Larry L.

“…A combination of Edman sequence analysis and mass spectrometry identified the major proteins of the young human lens as αA, αB, βA1, βA3, βA4, βB1, βB2, βB3,…”
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Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens by Ueda, Yoji, Fukiage, Chiho, Shih, Marjorie, Shearer, Thomas R, David, Larry L

“…Molecular chaperone activity of lens alpha-crystallins is reduced by loss of the C terminus. The purpose of this experiment was to 1) determine the cleavage…”
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Involvement of cyclooxygenase-2 in rat models of conjunctivitis by Oka, Takayuki, Shearer, Thomas, Azuma, Mitsuyoshi

“…Purpose. Using two animal models to determine which isoform of cyclooxygenase (COX), constitutive COX-1 or inducible COX-2, is involved in the progression of…”
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Degradation of human aquaporin 0 by m-calpain by Ma, H., Azuma, M., Shearer, T.R.

“…Opacities (cataracts) in the lens of the eye are a leading cause of preventable blindness. Aquaporins function as water channels, and the C-terminus is…”
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Biochemical properties of lens-specific calpain Lp85 by Shih, M., Ma, H., Nakajima, E., David, L.L., Azuma, M., Shearer, T.R.

“…Lens-specific Lp82 and ubiquitous m-calpain are neutral, calcium-activated, cysteine proteases. Both calpains are activated during rodent lens maturation and…”
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Histologic changes during selenite cataractogenesis: a light microscopy study by Shearer, T R, Anderson, R S

“…The purpose of this research was to study the early histologic changes occurring in the lens during the formation of selenite overdose cataract…”
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Characterization and Regulation of Lens-specific Calpain Lp82 by Fukiage, Chiho, Nakajima, Emi, Ma, Hong, Azuma, Mitsuyoshi, Shearer, Thomas R.

“…Eye tissues contain splice variants of muscle-preferred p94 (calpain 3), such as lens-specific Lp82 and Lp85, retina-specific Rt88, and cornea-specific Cn94…”
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Deamidation of Human βB1 Alters the Elongated Structure of the Dimer by Lampi, Kirsten J., Oxford, Julie T., Bachinger, Hans Peter, Shearer, Thomas R., David, Larry L., Kapfer, Deborah M.

“…The purpose of these experiments was to determine if truncation and deamidation alter the structure of a human lens protein, βB1-crystallin. Recombinant wild…”
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Involvement of Phosphorylation of Myosin Phosphatase by ROCK in Trabecular Meshwork and Ciliary Muscle Contraction by Fukiage, Chiho, Mizutani, Kanako, Kawamoto, Yoko, Azuma, Mitsuyoshi, Shearer, Thomas R.

“…The control of smooth muscle contraction is an important factor in maintaining normal intraoculer pressure. However, the specific factors causing changes in…”
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Cloning and expression of mRNA for calpain Lp82 from rat lens: splice variant of p94 by Ma, H, Fukiage, C, Azuma, M, Shearer, TR

“…To describe mRNA for Lp82, a lens-specific form of calcium-activated protease (EC 34.22.17, calpain) in rat. Total RNA was extracted from lenses of 12-day-old…”
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Expression changes in mRNAs and mitochondrial damage in lens epithelial cells with selenite by Belusko, P.B., Nakajima, T., Azuma, M., Shearer, T.R.

“…An overdose of sodium selenite induces cataracts in young rats. The mid-stage events producing the cataract include calpain-induced hydrolysis and…”
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Contribution of Calpain Lp82-Induced Proteolysis to Experimental Cataractogenesis in Mice by Nakamura, Yoshikuni, Fukiage, Chiho, Shih, Marjorie, Ma, Hong, David, Larry L, Azuma, Mitsuyoshi, Shearer, Thomas R

“…The purpose of the present experiments was to provide a biochemical mechanism for the involvement of lens-specific calpain Lp82 in experimental…”
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