Search Results - "Shea, Joanne"

CRISPR-engineered T cells in patients with refractory cancer by Stadtmauer, Edward A, Fraietta, Joseph A, Davis, Megan M, Cohen, Adam D, Weber, Kristy L, Lancaster, Eric, Mangan, Patricia A, Kulikovskaya, Irina, Gupta, Minnal, Chen, Fang, Tian, Lifeng, Gonzalez, Vanessa E, Xu, Jun, Jung, In-Young, Melenhorst, J Joseph, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Gaymon, Avery L, Desjardins, Stephanie, Lamontagne, Anne, Salas-Mckee, January, Fesnak, Andrew, Siegel, Donald L, Levine, Bruce L, Jadlowsky, Julie K, Young, Regina M, Chew, Anne, Hwang, Wei-Ting, Hexner, Elizabeth O, Carreno, Beatriz M, Nobles, Christopher L, Bushman, Frederic D, Parker, Kevin R, Qi, Yanyan, Satpathy, Ansuman T, Chang, Howard Y, Zhao, Yangbing, Lacey, Simon F, June, Carl H

“…CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a first-in-human phase 1 clinical…”
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Safety and efficacy of armored huCART19-IL18 in patients with relapsed/refractory lymphomas that progressed after anti-CD19 CAR T cells by Svoboda, Jakub, Landsburg, Daniel J, Nasta, Sunita Dwivedy, Barta, Stefan K., Chong, Elise A., Lariviere, Michael J., Shea, Joanne, Cervini, Amanda, Hexner, Elizabeth O., Marshall, Amy, Four, Megan, Leskowitz, Rachel M., Davis, Megan M., Hwang, Wei-Ting, Frey, Noelle V., Siegel, Donald L., Fraietta, Joseph A., Porter, David L., Schuster, Stephen J., June, Carl H.

“…7004 Background: A substantial proportion of patients (pts) with relapsed/refractory (R/R) non-Hodgkin lymphomas (NHL) will not derive a long-term benefit from…”
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Interleukin-18 Secreting Autologous Anti-CD19 CAR T-Cells (huCART19-IL18) in Patients with Non-Hodgkin Lymphomas Relapsed or Refractory to Prior CAR T-Cell Therapy by Svoboda, Jakub, Gerson, James N., Landsburg, Daniel J., Chong, Elise A., Barta, Stefan K., Dwivedy Nasta, Sunita, Ruella, Marco, Hexner, Elizabeth O., Marshall, Amy, Leskowitz, Rachel, Four, Megan, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Davis, Megan M., Gohil, Mercy, Scholler, John, Hasenmayer, Donald, Rojas Amortegui, Juliana, Brennan, Andrea, Plesa, Gabriela, Hwang, Wei-Ting, Porter, David L., Fraietta, Joseph, Schuster, Stephen J., June, Carl H.

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Phase I trial of autologous cMET-directed CAR-t cells administered intravenously in patients with melanoma & breast carcinoma by Shah, Payal D, Huang, Alexander Chan Chi, Xu, Xiaowei, Zhang, Paul J., Orlowski, Robert, Matlawski, Tina, Shea, Joanne, Cervini, Amanda, Amaravadi, Ravi K., Tchou, Julia C., Schuchter, Lynn Mara, Wherry, E. John, Linette, Gerald P., Mick, Rosemarie, Kulikovskaya, Irina, Lacey, Simon F., Plesa, Gabriela, June, Carl H., Vonderheide, Robert H., Mitchell, Tara C.

“…Abstract only 10035 Background: Advanced relapsed/refractory melanoma and metastatic triple-negative breast cancer are lethal diseases for which effective…”
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First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma by Stadtmauer, Edward A., Cohen, Adam D., Weber, Kristy, Lacey, Simon F, Gonzalez, Vanessa E., Melenhorst, J. Joseph, Fraietta, Joseph A, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Mangan, Patricia, Gaymon, Avery, Desjardins, Stephanie, Lancaster, Eric, Salas-Mckee, January, Suhoski, Megan M., Fesnak, Andrew, O'Rourke, Matthew, Lamontagne, Anne, Siegel, Don L., Young, Regina M, Chew, Anne, Nobles, Christopher L, Bushman, Frederic D., Chang, Howard Y., Satpathy, Ansuman T., Zhao, Yangbing, Hwang, Wei-Ting, Hexner, Elizabeth O., June, Carl H

“…Background: Autologous T cells genetically modified with a lentiviral vector to express affinity-enhanced T cell receptors (TCR) or chimeric antigen receptors…”
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Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma by Shah, Payal D, Huang, Alexander C, Xu, Xiaowei, Orlowski, Robert, Amaravadi, Ravi K, Schuchter, Lynn M, Zhang, Paul, Tchou, Julia, Matlawski, Tina, Cervini, Amanda, Shea, Joanne, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Marshall, Amy, Wherry, E John, Linette, Gerald P, Brennan, Andrea, Gonzalez, Vanessa, Kulikovskaya, Irina, Lacey, Simon F, Plesa, Gabriela, June, Carl H, Vonderheide, Robert H, Mitchell, Tara C

“…Treatments are limited for metastatic melanoma and metastatic triple-negative breast cancer (mTNBC). This pilot phase I trial (NCT03060356) examined the safety…”
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Phase IIa Trial of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed or Refractory CD19+ Lymphomas by Schuster, Stephen J., Svoboda, Jakub, Dwivedy Nasta, Sunita, Porter, David L., Chong, Elise A., Mahnke, Yolanda, Lacey, Simon F., Melenhorst, J. Joseph, Chew, Anne, Shah, Gaurav, Hasskarl, Jens, Litchman, Manuel, Wasik, Mariusz A., Landsburg, Daniel J., Mato, Anthony R., Garfall, Alfred L., Frey, Noelle V., Marcucci, Katherine T., Shea, Joanne, McConville, Holly, Zheng, Zhaohui, Levine, Bruce L., June, Carl H.

“…BACKGROUND: Autologous T cells genetically modified to express a chimeric antigen receptor consisting of an external anti-CD19 single chain antibody domain…”
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FEAR FIGHT OR FLIGHT by Shea, Joanne M

“…Why? Because you are scared - maybe even terrified. [...] the next time you are scared, remember that your body will help you fight any monsters or ghosts that…”
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Fear: fight or flight by Shea, Joanne M

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