Expression pattern of asialoglycoprotein receptor in human testis

Expression pattern of asialoglycoprotein receptor in human testis

During acute or chronic hepatitis B virus (HBV) infection, the virus can invade the male reproductive system, pass through the blood–testis barrier and integrate into the germ line, resulting in abnormal spermatozoa. However, the pathway remains unclear. The asialoglycoprotein receptor (ASGR), a pot...

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Bibliographic Details
Published in:Cell and tissue research Vol. 352; no. 3; pp. 761 - 768
Main Authors: Sun, Pingnan, Zheng, Junhong, She, Guizhou, Wei, Xiujing, Zhang, Xiaoyu, Shi, Haijun, Zhou, Xiaoling
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-06-2013
Springer
Springer Nature B.V
Subjects:
Asialoglycoprotein Receptor - genetics
Asialoglycoprotein Receptor - metabolism
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Blotting, Western
Cellular biology
chronic hepatitis B
Gene expression
Gene Expression Regulation
Glycoproteins
Health aspects
Hepatitis
Hepatitis B
Hepatitis B virus
hepatocytes
histochemistry
Human Genetics
Humans
Immunohistochemistry
In Situ Hybridization
Infection
Intermediate filament proteins
Leydig cells
liver
Male
Molecular Medicine
proliferating cell nuclear antigen
Proteomics
Regular Article
RNA, Messenger - genetics
RNA, Messenger - metabolism
seminiferous tubules
Seminiferous Tubules - cytology
Seminiferous Tubules - metabolism
Sertoli cells
Sertoli Cells - cytology
Sertoli Cells - metabolism
Signal transduction
Sperm
Spermatogonia - cytology
Spermatogonia - metabolism
spermatozoa
stromal cells
Testis - cytology
Testis - metabolism
vimentin
viruses
Sertoli cell
Asialoglycoprotein receptor
Leydig cell
Spermatogonium
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Summary:During acute or chronic hepatitis B virus (HBV) infection, the virus can invade the male reproductive system, pass through the blood–testis barrier and integrate into the germ line, resulting in abnormal spermatozoa. However, the pathway remains unclear. The asialoglycoprotein receptor (ASGR), a potential receptor for HBV, is mainly distributed in hepatocytes. We have examined the distribution of ASGR in human testis and found it in the seminiferous tubules and interstitial region but its enrichment in human testis is much lower than that in liver. By multiple immunoenzyme histochemistry staining, ASGR was precisely co-localized with vimentin (Sertoli cell marker) but not proliferating cell nuclear antigen (spermatogonial cell marker) in testis tissue. ASGR was expressed in human Leydig cells, stromal cells in the seminiferous tubules and Sertoli cells but seldom in spermatogonial cells. Therefore, ASGR could provide HBV with access to the luminal compartment of human testis. The mechanism by which HBV invades germ cells remains unknown.
Bibliography:http://dx.doi.org/10.1007/s00441-013-1616-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-013-1616-8