Antihypertensive therapy: controlling the processes of replicative cell senescence

The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biol...

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Bibliographic Details
Published in:	Rossiĭskiĭ kardiologicheskiĭ zhurnal Vol. 25; no. 3S; p. 3974
Main Authors:	Dudinskaya, E. N., Machekhina, L. V., Eruslanova, K. A., Dogotar, O. A., Ryltseva, L. P., Lyzlova, N. Yu, Shchepin, N. A., Kotovskaya, Yu. V., Tkacheva, O. N.
Format:	Journal Article
Language:	English
Published:	FIRMA «SILICEA» LLC 23-09-2020
Subjects:	aging hypertension insulin resistance oxidative stress telomerase telomeres
Online Access:	Get full text
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Summary:	The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biological and vascular aging, as well as possible ways of their reversal. The central indicators of biological aging in this review are telomere length and telomerase activity. The article discusses antihypertensive therapy as a possible way to slow down both vascular and biological aging, and describes the results of modern studies on the effect of various antihypertensives, including angiotensin-converting enzyme inhibitors, sartans and others, on the telomeres.
ISSN:	1560-4071 2618-7620
DOI:	10.15829/1560-4071-2020-3974