Search Results - "Shay, J"

Targeting telomerase for cancer therapeutics by Shay, J W, Keith, W N

“…One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although…”
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MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma by Mucaj, V, Lee, S S, Skuli, N, Giannoukos, D N, Qiu, B, Eisinger-Mathason, T S K, Nakazawa, M S, Shay, J E S, Gopal, P P, Venneti, S, Lal, P, Minn, A J, Simon, M C, Mathew, L K

“…Glioblastomas are aggressive adult brain tumors, characterized by inadequately organized vasculature and consequent nutrient and oxygen (O 2 )-depleted areas…”
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Is telomerase a viable target in cancer? by Buseman, C M, Wright, W E, Shay, J W

“…The ideal cancer treatment would specifically target cancer cells yet have minimal or no adverse effects on normal somatic cells. Telomerase, the…”
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Hallmarks of telomeres in ageing research by Shay, JW, Wright, WE

“…Telomeres are repetitive DNA sequences at the ends of linear chromosomes. Telomerase, a cellular reverse transcriptase, helps maintain telomere length in human…”
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A survey of telomerase activity in human cancer by Shay, J.W., Bacchetti, S.

“…Research on the association of the ribonucleoprotein enzyme, telomerase, with human cancer has expanded rapidly in recent years. Essentially all major types of…”
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Telomere Dysfunction: A Potential Cancer Predisposition Factor by Wu, Xifeng, Amos, Christopher I., Zhu, Yong, Zhao, Hua, Grossman, Barton H., Shay, Jerry W., Luo, Sherry, Hong, Waun Ki, Spitz, Margaret R.

“…Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the…”
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Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses by Kim, S B, Bozeman, R G, Kaisani, A, Kim, W, Zhang, L, Richardson, J A, Wright, W E, Shay, J W

“…Proton radiotherapy is becoming more common as protons induce more precise DNA damage at the tumor site with reduced side effects to adjacent normal tissues…”
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Telomerase and cancer by Shay, J W, Zou, Y, Hiyama, E, Wright, W E

“…Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription,…”
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Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation by Ng, W. L., Chen, G., Wang, M., Wang, H., Story, M., Shay, J. W., Zhang, X., Wang, J., Amin, A. R. M. R., Hu, B., Cucinotta, F. A., Wang, Y.

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Cellular senescence as a tumor-protection mechanism: the essential role of counting by Wright, Woodring E, Shay, Jerry W

“…The term ‘cellular senescence’ has often been applied indiscriminately to any form of growth arrest of cultured cells that occurs either after some period in…”
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Is the Geographic Distribution of Nesting in the Kemp’s Ridley Turtle Shaped by the Migratory Needs of Offspring? by Putman, Nathan F., Shay, Thomas J., Lohmann, Kenneth J.

“…Across the geographic area that a species uses for reproduction, the density of breeding individuals is typically highest in locations where ecological factors…”
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Telomere Position Effect in Human Cells by Baur, Joseph A., Zou, Ying, Shay, Jerry W., Wright, Woodring E.

“…In yeast, telomere position effect (TPE) results in the reversible silencing of genes near telomeres. Here we demonstrate the presence of TPE in human cells…”
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Inhibition of Human Telomerase in Immortal Human Cells Leads to Progressive Telomere Shortening and Cell Death by B.-S. Herbert, Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., Corey, D. R.

“…The correlation between telomerase activity and human tumors has led to the hypothesis that tumor growth requires reactivation of telomerase and that…”
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Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation by Ly, P, Kim, S B, Kaisani, A A, Marian, G, Wright, W E, Shay, J W

“…Trisomy for chromosome 7 is frequently observed as an initiating event in sporadic colorectal cancer. Although unstable chromosome numbers and recurrent…”
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Thermally Induced Oxidation of [FeII(tacn)2](OTf)2 (tacn = 1,4,7‐triazacyclononane) by Li, Jia, Banerjee, Atanu, Preston, Debra R., Shay, Brian J., Adhikary, Amitiva, Sevilla, Michael D., Loloee, Reza, Staples, Richard J., Chavez, Ferman A.

“…We previously reported the spin‐crossover (SC) properties of [FeII(tacn)2](OTf)2 (1) (tacn = 1,4,7‐triazacyclononane). Upon heating under dynamic vacuum, 1…”
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Immortalization of epithelial progenitor cells mediated by resveratrol by Pearce, V P, Sherrell, J, Lou, Z, Kopelovich, L, Wright, W E, Shay, J W

“…Within the hierarchy of epithelial stem cells, normal progenitor cells may express regulated telomerase during renewal cycles of proliferation and…”
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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT by Weinrich, Scott L, Pruzan, Ron, Ma, Libin, Ouellette, Michel, Tesmer, Valeric M, Holt, Shawn E, Bodnar, Andrea G, Lichtsteiner, Serge, Kim, Nam W, Trager, James B, Taylor, Rebecca D, Carlos, Ruben, Andrews, William H, Wright, Woodring E, Shay, Jerry W, Harley, Calvin B, Morin, Gregg B

“…The maintenance of chromosome termini, or telomeres, requires the action of the enzyme telomerase, as conventional DNA polymerases cannot fully replicate the…”
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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells by Bodnar, Andrea G., Ouellette, Michel, Frolkis, Maria, Holt, Shawn E., Chiu, Choy-Pik, Morin, Gregg B., Harley, Calvin B., Shay, Jerry W., Lichsteiner, Serge, Wright, Woodring E.

“…Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that…”
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Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus by Sarosi, G., Brown, G., Jaiswal, K., Feagins, L. A., Lee, E., Crook, T. W., Souza, R. F., Zou, Y. S., Shay, J. W., Spechler, Stuart Jon

“…Barrett's esophagus develops when refluxed gastric juice injures the esophageal squamous lining and the injury heals through a metaplastic process in which…”
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Telomerase Immortalization of Human Myometrial Cells by CONDON, Jennifer, SU YIN, MAYHEW, Bobbie, WORD, R. Ann, WRIGHT, W. E, SHAY, J. W, RAINEY, William E

“…Several strategies have been described for the primary culture of human myometrial cells. However, primary cultures of myometrial cells have a limited life…”
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