Search Results - "Shawky, Ahmed M"

A Comprehensive Overview of Globally Approved JAK Inhibitors by Shawky, Ahmed M, Almalki, Faisal A, Abdalla, Ashraf N, Abdelazeem, Ahmed H, Gouda, Ahmed M

“…Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce…”
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A new dynamical modeling SEIR with global analysis applied to the real data of spreading COVID-19 in Saudi Arabia by Youssef, Hamdy M, Alghamdi, Najat A, Ezzat, Magdy A, El-Bary, Alaa A, Shawky, Ahmed M

“…SEIR model is a widely used and acceptable model to distinguish the outbreak of the COVID-19 epidemic in many countries. In the current work, a new proposed…”
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Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids by Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Ahmed, Muhammad Naeem, Hameed, Shahid, Ashfaq, Muhammad, Shawky, Ahmed M., Ibrahim, Mahmoud A. A., Sidhom, Peter A.

“…Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. Taking into account the significance of…”
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Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3- b ] Pyrrole Derivatives by Kamel, Moumen S, Belal, Amany, Aboelez, Moustafa O, Shokr, E Kh, Abdel-Ghany, H, Mansour, Hany S, Shawky, Ahmed M, El-Remaily, Mahmoud Abd El Aleem Ali Ali

“…Novel pyrrolo [2,3- ] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the…”
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Green synthesis of silver nanoparticles using Tropaeolum majus: Phytochemical screening and antibacterial studies by Bawazeer, Saud, Rauf, Abdur, Shah, Syed Uzair Ali, Shawky, Ahmed M., Al-Awthan, Yahya S., Bahattab, Omar Salem, Uddin, Ghias, Sabir, Javeria, El-Esawi, Mohamed A.

“…The green biosynthesis of metal nanoparticles of already explored phytomedicines has many advantages such as enhanced biological action, increased…”
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Type I-IV Halogen⋯Halogen Interactions: A Comparative Theoretical Study in Halobenzene⋯Halobenzene Homodimers by Ibrahim, Mahmoud A A, Saeed, Rehab R A, Shehata, Mohammed N I, Ahmed, Muhammad Naeem, Shawky, Ahmed M, Khowdiary, Manal M, Elkaeed, Eslam B, Soliman, Mahmoud E S, Moussa, Nayra A M

“…In the current study, unexplored type IV halogen⋯halogen interaction was thoroughly elucidated, for the first time, and compared to the well-established types…”
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Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR by Almalki, Faisal A, Shawky, Ahmed M, Abdalla, Ashraf N, Gouda, Ahmed M

“…In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR…”
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Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities by Shawky, Ahmed M., Ibrahim, Nashwa A., Abourehab, Mohammed A. S., Abdalla, Ashraf N., Gouda, Ahmed M.

“…In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were…”
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Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis by Amin, Faiq, Ibrahim, Mahmoud A A, Rizwan-Ul-Hasan, Syed, Khaliq, Saima, Gabr, Gamal A, Muhammad, Khan, Asra, Sidhom, Peter A, Tikmani, Prashant, Shawky, Ahmed M, Ahmad, Saara, Abidi, Syed Hani

“…The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR,…”
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In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents by Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Roshdy, Eslam, Mohamed, Dina E. M., Ali, Taha F. S., Gabr, Gamal A., Jaragh-Alhadad, Laila A., Mekhemer, Gamal A. H., Shawky, Ahmed M., Sidhom, Peter A., Abdelrahman, Alaa H. M.

“…Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD + -dependent and organize several biological…”
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A modified SEIR model applied to the data of COVID-19 spread in Saudi Arabia by Youssef, Hamdy M., Alghamdi, Najat A., Ezzat, Magdy A., El-Bary, Alaa A., Shawky, Ahmed M.

“…The Susceptible-Exposed-Infectious-Recovered (SEIR) model is an established and appropriate approach in many countries to ascertain the spread of the…”
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In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases by Almalki, Faisal A., Abdalla, Ashraf N., Shawky, Ahmed M., El Hassab, Mahmoud A., Gouda, Ahmed M.

“…In the current study, a simple in silico approach using free software was used with the experimental studies to optimize the antiproliferative activity and…”
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Study on the SEIQR model and applying the epidemiological rates of COVID-19 epidemic spread in Saudi Arabia by Youssef, Hamdy, Alghamdi, Najat, Ezzat, Magdy A., El-Bary, Alaa A., Shawky, Ahmed M.

“…This article attempts to establish a mathematical epidemic model for the outbreak of the new COVID-19 coronavirus. A new consideration for evaluating and…”
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Exploring Natural Product Activity and Species Source Candidates for Hunting ABCB1 Transporter Inhibitors: An In Silico Drug Discovery Study by Ibrahim, Mahmoud A A, Abdeljawaad, Khlood A A, Abdelrahman, Alaa H M, Jaragh-Alhadad, Laila A, Oraby, Hesham Farouk, Elkaeed, Eslam B, Mekhemer, Gamal A H, Gabr, Gamal A, Shawky, Ahmed M, Sidhom, Peter A, Soliman, Mahmoud E S, Moustafa, Mahmoud F, Paré, Paul W, Hegazy, Mohamed-Elamir F

“…The P-glycoprotein (P-gp/ABCB1) is responsible for a xenobiotic efflux pump that shackles intracellular drug accumulation. Additionally, it is included in the…”
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Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents by Shawky, Ahmed M., Ibrahim, Nashwa A., Abdalla, Ashraf N., Abourehab, Mohammed A. S., Gouda, Ahmed M.

“…In the present study, two new series of pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety were designed, synthesised, and evaluated for their cytotoxic…”
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Combination of an Oxindole Derivative with (-)-β-Elemene Alters Cell Death Pathways in FLT3/ITD + Acute Myeloid Leukemia Cells by Alanazi, Jowaher, Bender, Onur, Dogan, Rumeysa, Malik, Jonaid Ahmad, Atalay, Arzu, Ali, Taha F S, Beshr, Eman A M, Shawky, Ahmed M, Aly, Omar M, Alqahtani, Yasir Nasser H, Anwar, Sirajudheen

“…Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options…”
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Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents by El-Sheref, Essmat M., Elbastawesy, Mohammed A. I., Brown, Alan B., Shawky, Ahmed M., Gomaa, Hesham A. M., Bräse, Stefan, Youssif, Bahaa G. M.

“…A mild and versatile method based on Cu-catalyzed [2+3] cycloaddition (Huisgen-Meldal-Sharpless reaction) was developed to tether…”
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Synthesis and Evaluation of Novel S -alkyl Phthalimide- and S -benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase by Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Jalil, Saquib, Ejaz, Syeda Abida, Iqbal, Jamshed, Shawky, Ahmed M, Alqahtani, Alaa M, Gabr, Gamal A, Ibrahim, Mahmoud A A, Sidhom, Peter A

“…New -alkyl phthalimide - and -benzyl - analogs of 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazole-2-thiol ( ) were prepared by reacting with -bromoalkylphthalimide…”
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External Electric Field Effect on the Strength of σ-Hole Interactions: A Theoretical Perspective in Like⋯Like Carbon-Containing Complexes by Ibrahim, Mahmoud A A, Moussa, Nayra A M, Kamel, Afnan A K, Shehata, Mohammed N I, Ahmed, Muhammad Naeem, Taha, Fouad, Abourehab, Mohammed A S, Shawky, Ahmed M, Elkaeed, Eslam B, Soliman, Mahmoud E S

“…For the first time, σ-hole interactions within like⋯like carbon-containing complexes were investigated, in both the absence and presence of the external…”
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Effects of Lewis Basicity and Acidity on σ-Hole Interactions in Carbon-Bearing Complexes: A Comparative Ab Initio Study by Ibrahim, Mahmoud A. A., Shehata, Mohammed N. I., Rady, Al-shimaa S. M., Abuelliel, Hassan A. A., Abd Elhafez, Heba S. M., Shawky, Ahmed M., Oraby, Hesham Farouk, Hasanin, Tamer H. A., Soliman, Mahmoud E. S., Moussa, Nayra A. M.

“…The effects of Lewis basicity and acidity on σ-hole interactions were investigated using two sets of carbon-containing complexes. In Set I, the effect of Lewis…”
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