Search Results - "Shawber, Carrie J"

Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy by Ruscitto, Angela, Morel, Mallory M., Shawber, Carrie J., Reeve, Gwendolyn, Lecholop, Michael K., Bonthius, Daniel, Yao, Hai, Embree, Mildred C.

“…Temporomandibular joint osteoarthritis (TMJ OA) leads to permanent cartilage destruction, jaw dysfunction, and compromises the quality of life. However, the…”
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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner by Pajvani, Utpal B, Shawber, Carrie J, Samuel, Varman T, Birkenfeld, Andreas L, Shulman, Gerald I, Kitajewski, Jan, Accili, Domenico

“…Notch, a molecule widely known for its role in development and cancer, regulates hepatic glucose metabolism by offsetting excessive glucose production. Given…”
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A new paradigm for the role of smooth muscle cells in the human cervix by Vink, Joy Y., MD, Qin, Sisi, PhD, Brock, Clifton O., MD, Zork, Noelia M., MD, Feltovich, Helen M., MD, Chen, Xiaowei, MD, Urie, Paul, MD, Myers, Kristin M., PhD, Hall, Timothy J., PhD, Wapner, Ronald, MD, Kitajewski, Jan K., PhD, Shawber, Carrie J., PhD, Gallos, George, MD

“…Background Premature cervical remodeling resulting in spontaneous preterm birth may begin with premature failure or relaxation at the internal os (termed…”
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Propranolol Therapy for Congenital Chylothorax by Handal-Orefice, Roxane, Midura, Devin, Wu, June K, Parravicini, Elvira, Miller, Russell S, Shawber, Carrie J

“…Congenital chylothorax is a rare and often severe anomaly without well-established medical therapies. Previously, propranolol use in patients with lymphatic…”
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Placental response to maternal SARS-CoV-2 infection by Mourad, Mirella, Jacob, Taylor, Sadovsky, Elena, Bejerano, Shai, Simone, Glicella Salazar-De, Bagalkot, Tarique Rajasaheb, Zucker, Jason, Yin, Michael T., Chang, Jennifer Y., Liu, Lihong, Debelenko, Larisa, Shawber, Carrie J., Firestein, Morgan, Ouyang, Yingshi, Gyamfi-Bannerman, Cynthia, Penn, Anna, Sorkin, Alexander, Wapner, Ronald, Sadovsky, Yoel

“…The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched…”
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Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium by Murtomaki, Aino, Uh, Minji K, Choi, Yun K, Kitajewski, Christopher, Borisenko, Valeriya, Kitajewski, Jan, Shawber, Carrie J

“…In development, lymphatic endothelial cells originate within veins and differentiate via a process requiring Prox1. Notch signaling regulates cell-fate…”
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Notch signaling functions in lymphatic valve formation by Murtomaki, Aino, Uh, Minji K, Kitajewski, Chris, Zhao, Jin, Nagasaki, Takayuki, Shawber, Carrie J, Kitajewski, Jan

“…Collecting lymphatic ducts contain intraluminal valves that prevent backflow. In mice, lymphatic valve morphogenesis begins at embryonic day 15.5 (E15.5). In…”
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Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration by Perlman, Barry E, Merriam, Audrey A, Lemenze, Alexander, Zhao, Qingshi, Begum, Salma, Nair, Mohan, Wu, Tracy, Wapner, Ronald J, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C

“…In the first trimester of human pregnancy, low oxygen tension or hypoxia is essential for proper placentation and placenta function. Low oxygen levels and…”
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A Foxo/Notch pathway controls myogenic differentiation and fiber type specification by Kitamura, Tadahiro, Kitamura, Yukari Ido, Funahashi, Yasuhiro, Shawber, Carrie J, Castrillon, Diego H, Kollipara, Ramya, DePinho, Ronald A, Kitajewski, Jan, Accili, Domenico

“…Forkhead box O (Foxo) transcription factors govern metabolism and cellular differentiation. Unlike Foxo-dependent metabolic pathways and target genes, the…”
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Notch function in the vasculature: insights from zebrafish, mouse and man by Shawber, Carrie J., Kitajewski, Jan

“…Vascular development entails multiple cell‐fate decisions to specify a diverse array of vascular structures. Notch proteins are signaling receptors that…”
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Venous malformation vessels are improperly specified and hyperproliferative by Schonning, Michael J, Koh, Seung, Sun, Ravi W, Richter, Gresham T, Edwards, Andrew K, Shawber, Carrie J, Wu, June K

“…Venous malformations (VMs) are slow-flow malformations of the venous vasculature and are the most common type of vascular malformation with a prevalence of 1%…”
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Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy by Marchetto, Nicole M, Begum, Salma, Wu, Tracy, O'Besso, Valerie, Yarborough, Christina C, Valero-Pacheco, Nuriban, Beaulieu, Aimee M, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C

“…Maternal spiral arteries and newly formed decidual capillaries support embryonic development prior to placentation. Previous studies demonstrated that Notch…”
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Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts by Werth, Max, Schmidt-Ott, Kai M, Leete, Thomas, Qiu, Andong, Hinze, Christian, Viltard, Melanie, Paragas, Neal, Shawber, Carrie J, Yu, Wenqiang, Lee, Peter, Chen, Xia, Sarkar, Abby, Mu, Weiyi, Rittenberg, Alexander, Lin, Chyuan-Sheng, Kitajewski, Jan, Al-Awqati, Qais, Barasch, Jonathan

“…Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells,…”
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Pathophysiology of Slow-Flow Vascular Malformations: Current Understanding and Unanswered Questions by Clapp, Averill, Shawber, Carrie J., Wu, June K.

“…Background: Slow-flow vascular malformations include venous, lymphatic, and lymphaticovenous malformations. Recent studies have linked genetic variants…”
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Aberrant lymphatic endothelial progenitors in lymphatic malformation development by Wu, June K, Kitajewski, Christopher, Reiley, Maia, Keung, Connie H, Monteagudo, Julie, Andrews, John P, Liou, Peter, Thirumoorthi, Arul, Wong, Alvin, Kandel, Jessica J, Shawber, Carrie J

“…Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease…”
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A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis by Funahashi, Yasuhiro, Hernandez, Sonia L, Das, Indranil, Ahn, Audrey, Huang, Jianzhong, Vorontchikhina, Marina, Sharma, Anshula, Kanamaru, Emi, Borisenko, Valeriya, Desilva, Dinuka M, Suzuki, Akihiko, Wang, Xing, Shawber, Carrie J, Kandel, Jessica J, Yamashiro, Darrell J, Kitajewski, Jan

“…Notch signaling is required for vascular development and tumor angiogenesis. Although inhibition of the Notch ligand Delta-like 4 can restrict tumor growth and…”
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Dynamic maternal and fetal Notch activity and expression in placentation by Levin, Heather I, Sullivan-Pyke, Chantae S, Papaioannou, Virginia E, Wapner, Ronald J, Kitajewski, Jan K, Shawber, Carrie J, Douglas, Nataki C., M.D., PhD

“…Abstract Introduction Murine placentation requires trophoblast Notch2, while the Notch ligand, JAGGED1, is reduced in invasive trophoblasts from women with…”
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Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2–driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells by García-Pascual, Carmen M., Ph.D, Zimmermann, Ralf C., M.D, Ferrero, Hortensia, Ph.D, Shawber, Carrie J., Ph.D, Kitajewski, Jan, Ph.D, Simón, Carlos, M.D, Pellicer, Antonio, M.D, Gómez, Raúl, Ph.D

“…Objective To explore whether the Dll4/Notch-1 signaling pathway modulates vascular endothelial growth factor (VEGF)-dependent luteal angiogenesis and related…”
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Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity by Funahashi, Yasuhiro, Shawber, Carrie J, Sharma, Anshula, Kanamaru, Emi, Choi, Yun K, Kitajewski, Jan

“…In the vasculature, Notch signaling functions as a downstream effecter of Vascular Endothelial Growth Factor (VEGF) signaling. VEGF regulates sprouting…”
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Notch regulates the angiogenic response via induction of VEGFR-1 by Funahashi, Yasuhiro, Shawber, Carrie J, Vorontchikhina, Marina, Sharma, Anshula, Outtz, Hasina H, Kitajewski, Jan

“…Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis…”
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