Search Results - "Shaw, Scott A."

Decarboxylative Alkynylation by Smith, Joel M., Qin, Tian, Merchant, Rohan R., Edwards, Jacob T., Malins, Lara R., Liu, Zhiqing, Che, Guanda, Shen, Zichao, Shaw, Scott A., Eastgate, Martin D., Baran, Phil S.

“…The development of a new decarboxylative cross‐coupling method that affords terminal and substituted alkynes from various carboxylic acids is described using…”
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AcOLeDMAP and BnOLeDMAP: Conformationally Restricted Nucleophilic Catalysts for Enantioselective Rearrangement of Indolyl Acetates and Carbonates by Duffey, Trisha A, Shaw, Scott A, Vedejs, Edwin

“…The rate of indolyl O- to C-acetyl or carboxyl rearrangement is accelerated by the electron-withdrawing N-diphenylacetyl group (DPA) using the conformationally…”
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Development of Chiral Nucleophilic Pyridine Catalysts:  Applications in Asymmetric Quaternary Carbon Synthesis by Shaw, Scott A, Aleman, Pedro, Vedejs, Edwin

“…TADMAP (1a), a new chiral DMAP catalyst, has been designed to place a C(3)-benzylic trityl group over one face of the pyridine ring, while a C(3)-benzylic…”
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Enantioselective TADMAP-Catalyzed Carboxyl Migration Reactions for the Synthesis of Stereogenic Quaternary Carbon by Shaw, Scott A, Aleman, Pedro, Christy, Justin, Kampf, Jeff W, Va, Porino, Vedejs, Edwin

“…The chiral, nucleophilic catalyst TADMAP [1, 3-(2,2,2-triphenyl-1-acetoxyethyl)-4-(dimethylamino)pyridine] has been prepared from…”
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Decarboxylative alkenylation by Edwards, Jacob T., Merchant, Rohan R., McClymont, Kyle S., Knouse, Kyle W., Qin, Tian, Malins, Lara R., Vokits, Benjamin, Shaw, Scott A., Bao, Deng-Hui, Wei, Fu-Liang, Zhou, Ting, Eastgate, Martin D., Baran, Phil S.

“…Starting with alkyl carboxylic acids, a simple olefin synthesis using any substitution pattern or geometry, based on amide-bond synthesis with nickel- or…”
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Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids by Wang, Jie, Qin, Tian, Chen, Tie-Gen, Wimmer, Laurin, Edwards, Jacob T., Cornella, Josep, Vokits, Benjamin, Shaw, Scott A., Baran, Phil S.

“…A transformation analogous in simplicity and functional group tolerance to the venerable Suzuki cross‐coupling between alkyl‐carboxylic acids and boronic acids…”
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Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis by Palkowitz, Maximilian D., Laudadio, Gabriele, Kolb, Simon, Choi, Jin, Oderinde, Martins S., Ewing, Tamara El-Hayek, Bolduc, Philippe N., Chen, TeYu, Zhang, Hao, Cheng, Peter T. W., Zhang, Benxiang, Mandler, Michael D., Blasczak, Vanna D., Richter, Jeremy M., Collins, Michael R., Schioldager, Ryan L., Bravo, Martin, Dhar, T. G. Murali, Vokits, Benjamin, Zhu, Yeheng, Echeverria, Pierre-Georges, Poss, Michael A., Shaw, Scott A., Clementson, Sebastian, Petersen, Nadia Nasser, Mykhailiuk, Pavel K., Baran, Phil S.

“…A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo­(hetero)­arenes is…”
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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase by Shaw, Scott A., Vokits, Benjamin P., Dilger, Andrew K., Viet, Andrew, Clark, Charles G., Abell, Lynn M., Locke, Gregory A., Duke, Gerald, Kopcho, Lisa M., Dongre, Ashok, Gao, Ji, Krishnakumar, Arathi, Jusuf, Sutjano, Khan, Javed, Spronk, Steven A., Basso, Michael D., Zhao, Lei, Cantor, Glenn H., Onorato, Joelle M., Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.

“…[Display omitted] Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of…”
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Potent Triazolopyridine Myeloperoxidase Inhibitors by Wurtz, Nicholas R, Viet, Andrew, Shaw, Scott A, Dilger, Andrew, Valente, Meriah N, Khan, Javed A, Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A, Kopcho, Lisa, Abell, Lynn M, Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R, Duclos, Franck, Kick, Ellen K

“…Myeloperoxidase (MPO) generates reactive oxygen species that potentially contribute to many chronic inflammatory diseases. A recently reported…”
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Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development by Shaw, Scott A, Balasubramanian, Balu, Bonacorsi, Samuel, Cortes, Janet Caceres, Cao, Kevin, Chen, Bang-Chi, Dai, Jun, Decicco, Carl, Goswami, Animesh, Guo, Zhiwei, Hanson, Ronald, Humphreys, W. Griffith, Lam, Patrick Y. S, Li, Wenying, Mathur, Arvind, Maxwell, Brad D, Michaudel, Quentin, Peng, Li, Pudzianowski, Andrew, Qiu, Feng, Su, Shun, Sun, Dawn, Tymiak, Adrienne A, Vokits, Benjamin P, Wang, Bei, Wexler, Ruth, Wu, Dauh-Rurng, Zhang, Yingru, Zhao, Rulin, Baran, Phil S

“…Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation…”
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitors by Duclos, Franck, Abell, Lynn M, Harden, David G, Pike, Kristen, Nowak, Kimberly, Locke, Gregory A, Duke, Gerald J, Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A, Vokits, Benjamin P, Wurtz, Nicholas R, Viet, Andrew, Valente, Meriah N, Stachura, Sylwia, Sleph, Paul, Khan, Javed A, Gao, Ji, Dongre, Ashok R, Zhao, Lei, Wexler, Ruth R, Gordon, David A, Kick, Ellen K

“…Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to…”
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Sporolide B: synthetic studies by Gladding, Jeffery A., Bacci, James P., Shaw, Scott A., Smith, Amos B.

“…Studies directed toward the synthesis of the architecturally complex marine natural product sporolide B are described. Synthetic analysis suggested advanced…”
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Correction to “Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development” by Shaw, Scott A, Balasubramanian, Balu, Bonacorsi, Samuel, Caceres Cortes, Janet, Cao, Kevin, Chen, Bang-Chi, Dai, Jun, Decicco, Carl, Goswami, Animesh, Guo, Zhiwei, Hanson, Ronald, Humphreys, W. Griffith, Lam, Patrick Y. S, Li, Wenying, Mathur, Arvind, Maxwell, Brad D, Michaudel, Quentin, Peng, Li, Pudzianowski, Andrew, Qiu, Feng, Su, Shun, Sun, Dawn, Tymiak, Adrienne A, Vokits, Benjamin P, Wang, Bei, Wexler, Ruth, Wu, Dauh-Rurng, Zhang, Yingru, Zhao, Rulin, Baran, Phil S

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Decarboxylative Alkynylation by Smith, Joel M., Qin, Tian, Merchant, Rohan R., Edwards, Jacob T., Malins, Lara R., Liu, Zhiqing, Che, Guanda, Shen, Zichao, Shaw, Scott A., Eastgate, Martin D., Baran, Phil S.

“…The development of a new decarboxylative cross‐coupling method that affords terminal and substituted alkynes from various carboxylic acids is described using…”
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Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids by Wang, Jie, Qin, Tian, Chen, Tie-Gen, Wimmer, Laurin, Edwards, Jacob T., Cornella, Josep, Vokits, Benjamin, Shaw, Scott A., Baran, Phil S.

“…A transformation analogous in simplicity and functional group tolerance to the venerable Suzuki cross‐coupling between alkyl‐carboxylic acids and boronic acids…”
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Ni-catalyzed Cross-coupling of Redox-Active Esters with Boronic Acids by Wang, Jie, Qin, Tian, Chen, Tie-Gen, Wimmer, Laurin, Edwards, Jacob T., Cornella, Josep, Vokits, Benjamin, Shaw, Scott A., Baran, Phil S.

“…A transformation analogous in simplicity and functional group tolerance to the venerable Suzuki cross-coupling between alkyl-carboxylic acids and boronic acids…”
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Potent Triazolopyridine Myeloperoxidase Inhibitors by Wurtz, Nicholas R., Viet, Andrew, Shaw, Scott A., Dilger, Andrew, Valente, Meriah N., Khan, Javed A., Jusuf, Sutjano, Narayanan, Rangaraj, Fernando, Gayani, Lo, Fred, Liu, Xiaoqin, Locke, Gregory A., Kopcho, Lisa, Abell, Lynn M., Sleph, Paul, Basso, Michael, Zhao, Lei, Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.

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Triazolopyrimidines identified as reversible myeloperoxidase inhibitorsElectronic supplementary information (ESI) available: General synthetic methods, key compound characterization, assay methods, and crystallographic information are available in the ESI. See DOI: 10.1039/c7md00268h by Duclos, Franck, Abell, Lynn M, Harden, David G, Pike, Kristen, Nowak, Kimberly, Locke, Gregory A, Duke, Gerald J, Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A, Vokits, Benjamin P, Wurtz, Nicholas R, Viet, Andrew, Valente, Meriah N, Stachura, Sylwia, Sleph, Paul, Khan, Javed A, Gao, Ji, Dongre, Ashok R, Zhao, Lei, Wexler, Ruth R, Gordon, David A, Kick, Ellen K

“…Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to…”
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitors† †Electronic supplementary information (ESI) available: General synthetic methods, key compound characterization, assay methods, and crystallographic information are available in the ESI. See DOI: 10.1039/c7md00268h by Duclos, Franck, Abell, Lynn M., Harden, David G., Pike, Kristen, Nowak, Kimberly, Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Fernando, Gayani, Shaw, Scott A., Vokits, Benjamin P., Wurtz, Nicholas R., Viet, Andrew, Valente, Meriah N., Stachura, Sylwia, Sleph, Paul, Khan, Javed A., Gao, Ji, Dongre, Ashok R., Zhao, Lei, Wexler, Ruth R., Gordon, David A., Kick, Ellen K.

“…A novel myeloperoxidase inhibitor, 7-benzylether triazolopyrimidine was discovered which reversibly inhibits enzyme activity and shows pharmacodynamic effects…”
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Development of chiral pyridine catalysts: Applications in kinetic resolution and asymmetric quaternary carbon synthesis by Shaw, Scott A

“…A new chiral 4-(dimethylamino)pyridine (DMAP) analog was developed that used restricted rotation to create a chirotopic environment about the nucleophilic…”
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