Search Results - "Shaw, Philip J."

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme by Prommana, Parichat, Uthaipibull, Chairat, Wongsombat, Chayaphat, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth, Knuepfer, Ellen, Holder, Anthony A, Shaw, Philip J

“…Conventional reverse genetic approaches for study of Plasmodium malaria parasite gene function are limited, or not applicable. Hence, new inducible systems are…”
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Transcriptomic complexity of the human malaria parasite Plasmodium falciparum revealed by long-read sequencing by Shaw, Philip J, Kaewprommal, Pavita, Wongsombat, Chayaphat, Ngampiw, Chumpol, Taechalertpaisarn, Tana, Kamchonwongpaisan, Sumalee, Tongsima, Sissades, Piriyapongsa, Jittima

“…The Plasmodium falciparum human malaria parasite genome is incompletely annotated and does not accurately represent the transcriptomic diversity of this…”
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Antimalarial target vulnerability of the putative Plasmodium falciparum methionine synthase by Leela, Nirut, Prommana, Parichat, Kamchonwongpaisan, Sumalee, Taechalertpaisarn, Tana, Shaw, Philip J

“…possesses a cobalamin-dependent methionine synthase (MS). MS is putatively encoded by the PF3D7_1233700 gene, which is orthologous and syntenic in . However,…”
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Stepwise acquisition of pyrimethamine resistance in the malaria parasite by Lozovsky, Elena R, Chookajorn, Thanat, Brown, Kyle M, Imwong, Mallika, Shaw, Philip J, Kamchonwongpaisan, Sumalee, Neafsey, Daniel E, Weinreich, Daniel M, Hartl, Daniel L

“…The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible…”
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Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites by Sleebs, Brad E, Lopaticki, Sash, Marapana, Danushka S, O'Neill, Matthew T, Rajasekaran, Pravin, Gazdik, Michelle, Günther, Svenja, Whitehead, Lachlan W, Lowes, Kym N, Barfod, Lea, Hviid, Lars, Shaw, Philip J, Hodder, Anthony N, Smith, Brian J, Cowman, Alan F, Boddey, Justin A

“…The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe…”
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Apicoplast ribosomal protein S10-V127M enhances artemisinin resistance of a Kelch13 transgenic Plasmodium falciparum by Kampoun, Tanyaluck, Srichairatanakool, Somdet, Prommana, Parichat, Shaw, Philip J, Green, Judith L, Knuepfer, Ellen, Holder, Anthony A, Uthaipibull, Chairat

“…Abstract Background The resistance of Plasmodium falciparum to artemisinin-based (ART) drugs, the front-line drug family used in artemisinin-based combination…”
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Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling by Aroonsri, Aiyada, Akinola, Olugbenga, Posayapisit, Navaporn, Songsungthong, Warangkhana, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Gbotosho, Grace O., Yuthavong, Yongyuth, Shaw, Philip J.

“…[Display omitted] •The glmS ribozyme tool is functional in Plasmodium berghei.•Dihydrofolate reductase-thymidylate synthase (DHFR-TS) attenuated parasites are…”
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Antagonistic antimalarial properties of a methoxyamino chalcone derivative and 3-hydroxypyridinones in combination with dihydroartemisinin against Plasmodium falciparum by Kampoun, Tanyaluck, Koonyosying, Pimpisid, Ruangsuriya, Jetsada, Prommana, Parichat, Shaw, Philip J, Kamchonwongpaisan, Sumalee, Suwito, Hery, Puspaningsih, Ni Nyoman Tri, Uthaipibull, Chairat, Srichairatanakool, Somdet

“…The spread of artemisinin (ART)-resistant threatens the control of malaria. Mutations in the propeller domains of Kelch13 ( ) are strongly associated with ART…”
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ToNER: A tool for identifying nucleotide enrichment signals in feature-enriched RNA-seq data by Promworn, Yuttachon, Kaewprommal, Pavita, Shaw, Philip J, Intarapanich, Apichart, Tongsima, Sissades, Piriyapongsa, Jittima

“…Biochemical methods are available for enriching 5' ends of RNAs in prokaryotes, which are employed in the differential RNA-seq (dRNA-seq) and the more recent…”
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iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies by Piriyapongsa, Jittima, Ngamphiw, Chumpol, Intarapanich, Apichart, Kulawonganunchai, Supasak, Assawamakin, Anunchai, Bootchai, Chaiwat, Shaw, Philip J, Tongsima, Sissades

“…Genome-wide association studies (GWAS) do not provide a full account of the heritability of genetic diseases since gene-gene interactions, also known as…”
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Identifying transcript 5' capped ends in Plasmodium falciparum by Shaw, Philip J, Piriyapongsa, Jittima, Kaewprommal, Pavita, Wongsombat, Chayaphat, Chaosrikul, Chadapohn, Teeravajanadet, Krirkwit, Boonbangyang, Manon, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Tongsima, Sissades

“…The genome of the human malaria parasite is poorly annotated, in particular, the 5' capped ends of its mRNA transcripts. New approaches are needed to fully…”
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Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target by Aroonsri, Aiyada, Posayapisit, Navaporn, Kongsee, Jindaporn, Siripan, Onsiri, Vitsupakorn, Danoo, Utaida, Sugunya, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Shaw, Philip J

“…Hypusination is an essential post-translational modification in eukaryotes. The two enzymes required for this modification, namely deoxyhypusine synthase (DHS)…”
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PanSNPdb: the Pan-Asian SNP genotyping database by Ngamphiw, Chumpol, Assawamakin, Anunchai, Xu, Shuhua, Shaw, Philip J, Yang, Jin Ok, Ghang, Ho, Bhak, Jong, Liu, Edison, Tongsima, Sissades

“…The HUGO Pan-Asian SNP consortium conducted the largest survey to date of human genetic diversity among Asians by sampling 1,719 unrelated individuals among 71…”
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Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood by Tangprasittipap, Amornrat, Kaewprommal, Pavita, Sripichai, Orapan, Sathirapongsasuti, Nuankanya, Satirapod, Chonthicha, Shaw, Philip J, Piriyapongsa, Jittima, Hongeng, Suradej

“…A key event in human development is the establishment of erythropoietic progenitors in the bone marrow, which is accompanied by a fetal-to-adult switch in…”
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Uncovering full-length transcript isoforms of sugarcane cultivar Khon Kaen 3 using single-molecule long-read sequencing by Piriyapongsa, Jittima, Kaewprommal, Pavita, Vaiwsri, Sirintra, Anuntakarun, Songtham, Wirojsirasak, Warodom, Punpee, Prapat, Klomsa-Ard, Peeraya, Shaw, Philip J, Pootakham, Wirulda, Yoocha, Thippawan, Sangsrakru, Duangjai, Tangphatsornruang, Sithichoke, Tongsima, Sissades, Tragoonrung, Somvong

“…Sugarcane is an important global food crop and energy resource. To facilitate the sugarcane improvement program, genome and gene information are important for…”
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Study of large and highly stratified population datasets by combining iterative pruning principal component analysis and structure by Limpiti, Tulaya, Intarapanich, Apichart, Assawamakin, Anunchai, Shaw, Philip J, Wangkumhang, Pongsakorn, Piriyapongsa, Jittima, Ngamphiw, Chumpol, Tongsima, Sissades

“…The ever increasing sizes of population genetic datasets pose great challenges for population structure analysis. The Tracy-Widom (TW) statistical test is…”
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Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins by Wongsombat, Chayaphat, Aroonsri, Aiyada, Kamchonwongpaisan, Sumalee, Morgan, Hugh P., Walkinshaw, Malcolm D., Yuthavong, Yongyuth, Shaw, Philip J.

“…•Two Bruno/CELF homologues identified in P. falciparum (PfCELF1 and PfCELF2).•PfCELF1 shows RNA binding activity by UV crosslink assay.•PfCELF1 shows dual…”
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Iterative pruning PCA improves resolution of highly structured populations by Intarapanich, Apichart, Shaw, Philip J, Assawamakin, Anunchai, Wangkumhang, Pongsakorn, Ngamphiw, Chumpol, Chaichoompu, Kridsadakorn, Piriyapongsa, Jittima, Tongsima, Sissades

“…Non-random patterns of genetic variation exist among individuals in a population owing to a variety of evolutionary factors. Therefore, populations are…”
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Genetic analysis of Thai cattle reveals a Southeast Asian indicine ancestry by Wangkumhang, Pongsakorn, Wilantho, Alisa, Shaw, Philip J, Flori, Laurence, Moazami-Goudarzi, Katayoun, Gautier, Mathieu, Duangjinda, Monchai, Assawamakin, Anunchai, Tongsima, Sissades

“…Cattle commonly raised in Thailand have characteristics of Bos indicus (zebu). We do not know when or how cattle domestication in Thailand occurred, and so…”
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The Plasmodium berghei RC strain is highly diverged and harbors putatively novel drug resistance variants by Songsungthong, Warangkhana, Kulawonganunchai, Supasak, Wilantho, Alisa, Tongsima, Sissades, Koonyosying, Pongpisid, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Shaw, Philip J

“…The current first line drugs for treating uncomplicated malaria are artemisinin (ART) combination therapies. However, parasites resistant to ART and partner…”
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