Search Results - "Shaw, Michael H."

Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response by Sato, Yosuke, Fu, Yu, Liu, Hong, Lee, Min Young, Shaw, Michael H

“…Immune checkpoint blockade (ICB) therapies have changed the paradigm of cancer therapies. However, anti-tumor response of the ICB is insufficient for many…”
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The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes by Kim, Yun-Gi, Kamada, Nobuhiko, Shaw, Michael H., Warner, Neil, Chen, Grace Y., Franchi, Luigi, Núñez, Gabriel

“…The intracellular sensor Nod2 is activated in response to bacteria, and the impairment of this response is linked to Crohn's disease. However, the function of…”
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NOD-like receptors: role in innate immunity and inflammatory disease by Chen, Grace, Shaw, Michael H, Kim, Yun-Gi, Nuñez, Gabriel

“…The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the…”
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The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis by CHEN, Grace Y, SHAW, Michael H, REDONDO, Gloria, NUNEZ, Gabriel

“…There is growing evidence that the host innate immune system has a critical role in regulating carcinogenesis, but the specific receptors involved and the…”
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The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands by Kim, Yun-Gi, Park, Jong-Hwan, Shaw, Michael H., Franchi, Luigi, Inohara, Naohiro, Núñez, Gabriel

“…The cytosolic sensors Nod1 and Nod2 and Toll-like receptors (TLRs) activate defense signaling pathways in response to microbial stimuli. However, the role of…”
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Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy by Sato, Yosuke, Casson, Cierra N., Matsuda, Atsushi, Kim, James I., Shi, Judy Qiuju, Iwasaki, Shinji, Chen, Susan, Modrell, Brett, Chan, Chingkit, Tavares, Daniel, Austen, Douglas, Ida, Koh, Tayber, Olga, Hein, Pyae, Comeau, Robert, Lin, Yafang, Shaw, Michael H.

“…Ipilimumab, a monoclonal antibody that recognizes cytotoxic T-lymphocyte associated protein 4 (CTLA-4), was the first immune checkpoint inhibitor approved by…”
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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages by Ling, Yun M, Shaw, Michael H, Ayala, Carol, Coppens, Isabelle, Taylor, Gregory A, Ferguson, David J P, Yap, George S

“…Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV)…”
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Intracellular NOD-like receptors in innate immunity, infection and disease by Franchi, Luigi, Park, Jong-Hwan, Shaw, Michael H, Marina-Garcia, Noemi, Chen, Grace, Kim, Yun-Gi, Núñez, Gabriel

“…The innate immune system comprises several classes of pattern-recognition receptors, including Toll-like receptors (TLRs) and nucleotide binding and…”
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Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome by Reimer, Thornik, Shaw, Michael H, Franchi, Luigi, Coban, Cevayir, Ishii, Ken J, Akira, Shizuo, Horii, Toshihiro, Rodriguez, Ana, Núñez, Gabriel

“…Cerebral malaria is the most severe complication of Plasmodium falciparum infection in humans and the pathogenesis is still unclear. Using the P. berghei ANKA…”
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TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations by Colletti, Nicholas J, Liu, Hong, Gower, Adam C, Alekseyev, Yuriy O, Arendt, Christopher W, Shaw, Michael H

“…Conventional and plasmacytoid dendritic cells (cDCs and pDCs) are the two populations of DCs that can be readily identified in human blood. Conventional DCs…”
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NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense by Franchi, Luigi, Kamada, Nobuhiko, Nakamura, Yuumi, Burberry, Aaron, Kuffa, Peter, Suzuki, Shiho, Shaw, Michael H, Kim, Yun-Gi, Núñez, Gabriel

“…Discriminating between pathogens and commensals is a major dilemma faced by the immune system. Nunez et al . demonstrate that the recognition of bacterial…”
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Signal conversion as tumor micro environment (TME) specifically activated cytokine by Ida, Koh, Sato, Yosuke, Hikami, Koki, Magnay, Maureen, Shaw, Michael H.

“…Targeted cytokine delivery has been gaining popularity in cancer immunotherapy since systemic recombinant cytokine treatment has not been successful due to low…”
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A Natural Mutation in the Tyk2 Pseudokinase Domain Underlies Altered Susceptibility of B10.Q/J Mice to Infection and Autoimmunity by Shaw, Michael H., Boyartchuk, Victor, Wong, Sandy, Karaghiosoff, Marina, Ragimbeau, Josiane, Pellegrini, Sandra, Muller, Mathias, Dietrich, William F., Yap, George S.

“…The B10.Q/J strain of mice was serendipitously discovered to be highly susceptible to infection by the intracellular protozoan parasite, Toxoplasma gondii but…”
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Microbiota-dependent activation of CD4 + T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors by Lo, Bernard C, Kryczek, Ilona, Yu, Jiali, Vatan, Linda, Caruso, Roberta, Matsumoto, Masanori, Sato, Yosuke, Shaw, Michael H, Inohara, Naohiro, Xie, Yuying, Lei, Yu Leo, Zou, Weiping, Núñez, Gabriel

“…Immune checkpoint inhibitors can stimulate antitumor immunity but can also induce toxicities termed immune-related adverse events (irAEs). Colitis is a common…”
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NOD-like receptors (NLRs): bona fide intracellular microbial sensors by Shaw, Michael H, Reimer, Thornik, Kim, Yun-Gi, Nuñez, Gabriel

“…The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leucine-rich repeat containing) family of proteins has been…”
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T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii by Shaw, Michael H, Reimer, Thornik, Kim, Yun-Gi, Sánchez-Valdepeñas, Carmen, Warner, Neil, Nuñez, Gabriel, Fresno, Manuel

“…Nod2 senses intracellular bacteria and is required for their eradication. Nuñez and co-workers now describe a T cell–intrinsic role for Nod2 in combating the…”
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The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation by Shaw, Michael H, Kamada, Nobuhiko, Warner, Neil, Kim, Yun-Gi, Nuñez, Gabriel

“…The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response…”
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Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality by Kim, Yun-Gi, Shaw, Michael H, Warner, Neil, Park, Jong-Hwan, Chen, Felicia, Ogura, Yasunori, Núñez, Gabriel

“…Nucleotide-binding oligomerization domain 2 (Nod2) mutations including L1007fsinsC are associated with the development of Crohn's disease (CD). These…”
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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies by Carideo Cunniff, Elizabeth, Sato, Yosuke, Mai, Doanh, Appleman, Vicky A, Iwasaki, Shinji, Kolev, Vihren, Matsuda, Atsushi, Shi, Judy, Mochizuki, Michiyo, Yoshikawa, Masato, Huang, Jian, Shen, Luhua, Haridas, Satyajeet, Shinde, Vaishali, Gemski, Chris, Roberts, Emily R, Ghasemi, Omid, Bazzazi, Hojjat, Menon, Saurabh, Traore, Tary, Shi, Pu, Thelen, Tennille D, Conlon, Joseph, Abu-Yousif, Adnan O, Arendt, Christopher, Shaw, Michael H, Okaniwa, Masanori

“…Oncology therapies targeting the immune system have improved patient outcomes across a wide range of tumor types, but resistance due to an inadequate T-cell…”
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Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation by Shaw, Michael H, Freeman, Gordon J, Scott, Mark F, Fox, Barbara A, Bzik, David J, Belkaid, Yasmine, Yap, George S

“…The Jak, Tyk2, is activated in response to IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells. Mice deficient in Tyk2 function…”
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