Search Results - "Shaw, McKay"

Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA by Sutera, Vincent A., Weeks, Savannah J., Dudenhausen, Elizabeth E., Baggett, Helen B. Rappe, Shaw, McKay C., Brand, Kirsten A., Glass, David J., Bloom, Linda B., Lovett, Susan T.

“…[Display omitted] •HolC binds to two exclusive partners, the clamp-loader protein, HolD or the repair helicase, YoaA.•HolC residues W57 and F64 are required…”
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CLL-1-Targeted Allogeneic CAR-T Cells Exhibit High on-Target Specificity and Potent Cytotoxicity in Preclinical Models of Acute Myeloid Leukemia by Francica, Brian, Garner, Elizabeth, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Kelly, Erin, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Lauer, Peter, Skoble, Justin, Kanner, Steven

“…Background: CLL-1 is a compelling therapeutic target for acute myeloid leukemia (AML) as it is highly expressed on AML tumor cells and leukemic stem cells, but…”
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CB-011, a BCMA-Specific Allogeneic CAR-T Cell Therapy, Engineered with Next-Generation CRISPR Technology to Express an HLA-E Fusion Transgene to Prevent Immune Cell-Mediated Rejection, for r/r Multiple Myeloma by Garner, Elizabeth, Degagne, Emilie, Roy, Suparna, Donohoue, Paul, Fowler, Tristan, Stanaway, Morena, Vicena, Vanina, Mutha, Devin, Schilling, Benjamin, Shaw, McKay, Bryan, Mara, Edwards, Leslie, Smith, Stephen, Kohrs, Bryan, Banh, Lynda, McSweeney, Kyle, Skoble, Justin, Kanner, Steven

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524 - CB-011, a BCMA-Specific Allogeneic CAR-T Cell Therapy, Engineered with Next-Generation CRISPR Technology to Express an HLA-E Fusion Transgene to Prevent Immune Cell-Mediated Rejection, for r/r Multiple Myeloma by Garner, Elizabeth, Degagne, Emilie, Roy, Suparna, Donohoue, Paul, Fowler, Tristan, Stanaway, Morena, Vicena, Vanina, Mutha, Devin, Schilling, Benjamin, Shaw, McKay, Bryan, Mara, Edwards, Leslie, Smith, Stephen, Kohrs, Bryan, Banh, Lynda, McSweeney, Kyle, Skoble, Justin, Kanner, Steven

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Abstract 6323: Preclinical evaluation of CB-012, an allogeneic anti-CLL-1 CAR-T cell therapy, that exhibits specific and potent toxicity in acute myeloid leukemia (AML) xenograft models by Francica, Brian, Garner, Elizabeth, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Kelly, Erin, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Lauer, Peter, Skoble, Justin, Kanner, Steven

“…Abstract Background: CLL-1 is a compelling therapeutic target for AML as it is highly expressed on AML tumor cells and leukemic stem cells but is not expressed…”
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Abstract LB009: A BCMA-specific allogeneic CAR-T cell therapy (CB-011) genome-engineered to express an HLA-E fusion transgene to prevent immune cell rejection by Garner, Elizabeth, Degagne, Emilie, Roy, Suparna, Donohoue, Paul, Fowler, Tristan, Stanaway, Morena, Vicena, Vanina, Mutha, Devin, Schilling, Benjamin, Shaw, McKay, Bryan, Mara, Edwards, Leslie, Smith, Stephen, Kohrs, Bryan, Banh, Lynda, McSweeney, Kyle, Skoble, Justin, Kanner, Steven

“…Abstract The approval and commercial launch of multiple first-generation CD19- or BCMA-directed, autologous CAR-T cell products have laid the foundation and…”
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Abstract 3201: CB-012, an allogeneic anti-CLL-1 CAR-T cell therapy engineered with next-generation CRISPR technology to resist both the immunosuppressive tumor microenvironment and immune cell-mediated rejection, for patients with relapsed or refractory acute myeloid leukemia by Garner, Elizabeth, Kelly, Erin, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Skoble, Justin, Kanner, Steven

“…Abstract Background: CB-012 is an allogeneic anti-CLL-1 CAR-T cell therapy in development for evaluation in relapsed or refractory acute myeloid leukemia (r/r…”
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