Search Results - "Shaw, Maureen A."

Heparin Mimic Material Derived from Cellulose Nanocrystals by Gallagher, Zahra J, Fleetwood, Sara, Kirley, Terence L, Shaw, Maureen A, Mullins, Eric S, Ayres, Neil, Foster, E. Johan

“…This study analyzes and evaluates the use of cellulose nanocrystals (CNCs), stiff nanosized natural materials that have been modified to mimic heparin. These…”
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Synthesis and Anticoagulant Activity of Polyureas Containing Sulfated Carbohydrates by Huang, Yongshun, Shaw, Maureen A, Mullins, Eric S, Kirley, Terence L, Ayres, Neil

“…Polyurea-based synthetic glycopolymers containing sulfated glucose, mannose, glucosamine, or lactose as pendant groups have been synthesized by step-growth…”
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Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease by Shaw, Maureen A, Gao, Zhen, McElhinney, Kathryn E, Thornton, Sherry, Flick, Matthew J, Lane, Adam, Degen, Jay L, Ryu, Jae Kyu, Akassoglou, Katerina, Mullins, Eric S

“…Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease of the CNS. Fibrinogen deposition at sites of blood-brain barrier breakdown is a…”
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Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice by Arumugam, Paritha I., Mullins, Eric S., Shanmukhappa, Shiva Kumar, Monia, Brett P., Loberg, Anastacia, Shaw, Maureen A., Rizvi, Tilat, Wansapura, Janaka, Degen, Jay L., Malik, Punam

“…Sickle cell disease (SCD) results in vascular occlusions, chronic hemolytic anemia, and cumulative organ damage. A conspicuous feature of SCD is chronic…”
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Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen by Steinbrecher, Kris A, Horowitz, Netanel A, Blevins, Elizabeth A, Barney, Kelley A, Shaw, Maureen A, Harmel-Laws, Eleana, Finkelman, Fred D, Flick, Matthew J, Pinkerton, Malinda D, Talmage, Kathryn E, Kombrinck, Keith W, Witte, David P, Palumbo, Joseph S

“…A link between colitis and colon cancer is well established, but the mechanisms regulating inflammation in this context are not fully defined. Given…”
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Colitis-Associated Cancer Is Dependent on the Interplay between the Hemostatic and Inflammatory Systems and Supported by Integrin αMβ2 Engagement of Fibrinogen by STEINBRECHER, Kris A, HOROWITZ, Netanel A, KOMBRINCK, Keith W, WITTE, David P, PALUMBO, Joseph S, BLEVINS, Elizabeth A, BARNEY, Kelley A, SHAW, Maureen A, HARMEL-LAWS, Eleana, FINKELMAN, Fred D, FLICK, Matthew J, PINKERTON, Malinda D, TALMAGE, Kathryn E

“…A link between colitis and colon cancer is well established, but the mechanisms regulating inflammation in this context are not fully defined. Given…”
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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice by Shaw, Maureen A., Kombrinck, Keith W., McElhinney, Kathryn E., Sweet, David R., Flick, Matthew J., Palumbo, Joseph S., Cheng, Mei, Esmon, Naomi L., Esmon, Charles T., Brill, Alexander, Wagner, Denisa D., Degen, Jay L., Mullins, Eric S.

“…Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of…”
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Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain by Mullins, Eric S., Kombrinck, Keith W., Talmage, Kathryn E., Shaw, Maureen A., Witte, David P., Ullman, Joni M., Degen, Sandra J., Sun, William, Flick, Matthew J., Degen, Jay L.

“…Mice carrying a conditional prothrombin knockout allele (fIIlox) were established to develop an experimental setting for exploring the importance of thrombin…”
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Elimination of the fibrinogen integrin αMβ2-binding motif improves renal pathology in mice with sickle cell anemia by Nasimuzzaman, Md, Arumugam, Paritha I., Mullins, Eric S., James, Jeanne M., VandenHeuvel, Katherine, Narciso, Marilou G., Shaw, Maureen A., McGraw, Sarah, Aronow, Bruce J., Malik, Punam

“…Sickle cell anemia (SCA) is caused by a point mutation in the β-globin gene that leads to devastating downstream consequences including chronic hemolytic…”
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Plasmin(ogen) Mediates Macrophage Migration in a Fibrin(ogen) Dependent Mechanism by Shaw, Maureen A., Gao, Zhen, Mullins, Eric S.

“…Mounting evidence ties both fibrin(ogen) and plasmin(ogen) to inflammatory diseases. Indeed, both fibrin(ogen) and plasmin(ogen) have been linked to critical…”
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Consumption of a high fat diet impairs reproductive performance in Sprague-Dawley rats by Shaw, M A, Rasmussen, K M, Myers, T R

“…Rats made obese by cafeteria feeding have poor reproductive outcomes. To investigate this phenomenon in animals fed a more nutritionally adequate diet, female…”
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Plasmin-Mediated Fibrinolysis Enables Macrophage Migration Via Liberation from Fibrin-αMβ2 Interactions by Mullins, Eric S., Shaw, Maureen A., Gao, Zhen, Flick, Matthew J.

“…Mounting evidence ties both fibrin(ogen) and plasmin(ogen) to inflammatory diseases. Indeed, both fibrin(ogen) and plasmin(ogen) have been linked to critical…”
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Mice Lacking Factor XIII Have Significant Protection from the Progression of Neuroinflammatory Disease by Gao, Zhen, Shaw, Maureen A., Palumbo, Joseph S., Flick, Matthew J., Mullins, Eric S.

“…Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Motor and sensory neurologic deficits…”
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Teacher Perspective of the Educational Impact when Transitioning to a Virtual Setting During a Pandemic by Shaw, Maureen A

“…The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) outbreak, which led to the COVID-19 pandemic, was a catalyst for major changes for schools in…”
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Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited by Nasimuzzaman, Md, Arumugam, Paritha I., Mullins, Eric S., James, Jeanne M, VandenHeuvel, Katherine, Narciso, Marilou, Shaw, Maureen A., McGraw, Sarah, Aronow, Bruce J., Flick, Matthew J., Malik, Punam

“…Sickle cell anemia (SCA) is caused by a point mutation in the beta-globin gene. SCA has potentially devastating consequences including chronic hemolytic…”
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Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis by Mullins, Eric S., Shaw, Maureen A, McElhinney, Kathryn E, Kombrinck, Keith W., Degen, Jay L.

“…Multiple sclerosis (MS) is a chronic neuroinflammatory disease that is characterized by relapsing/remitting or progressive motor and sensory defects. These…”
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Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels by Arumugam, Paritha, Mullins, Eric S., Shaw, Maureen A, Shanmukhappa, Kumar, Loberg, Anastacia, Rizvi, Tilat, Wansapura, Janaka, Witte, David, Malik, Punam, Degen, Jay L.

“…Sickle cell disease (SCD) is characterized by chronic hemolytic anemia, vaso-occlusions, chronic inflammation and an oxidative state, with progressive and…”
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Elimination of the fibrinogen integrin α M β 2 -binding motif improves renal pathology in mice with sickle cell anemia by Nasimuzzaman, Md, Arumugam, Paritha I, Mullins, Eric S, James, Jeanne M, VandenHeuvel, Katherine, Narciso, Marilou G, Shaw, Maureen A, McGraw, Sarah, Aronow, Bruce J, Malik, Punam

“…Sickle cell anemia (SCA) is caused by a point mutation in the β-globin gene that leads to devastating downstream consequences including chronic hemolytic…”
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Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation by Mullins, Eric S., Shaw, Maureen A., McElhinney, Kathryn E., Kombrinck, Keith W., Flick, Matthew J., Brill, Alexander, Wagner, Denisa D., Degen, Jay L.

“…Abstract 496 Thrombin-mediated proteolysis is the central event not only of hemostasis and thrombosis but also in distinct physiological and pathological…”
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Fibrinogen Supports Colitis-Associated Adenoma Progression through a Mechanism Coupled to Engagement of the Leukocyte Integrin αMβ2 by Horowitz, Netanel, Steinbrecher, Kris A., Shaw, Maureen A., Barney, Kelley A., Flick, Matthew, Harmel-Laws, Eleana, Witte, David, Blevins, Elizabeth A., Palumbo, Joseph S.

“…Abstract 334▪▪This icon denotes an abstract that is clinically relevant. A growing body of evidence points to a crucial role for fibrinogen in both tumor…”
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