Search Results - "Shaw, Lisa E"

The Extracellular Matrix in Skin Inflammation and Infection by Pfisterer, Karin, Shaw, Lisa E., Symmank, Dörte, Weninger, Wolfgang

“…The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought…”
Get full text

The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy by Tong, Philip L., Roediger, Ben, Kolesnikoff, Natasha, Biro, Maté, Tay, Szun S., Jain, Rohit, Shaw, Lisa E., Grimbaldeston, Michele A., Weninger, Wolfgang

“…Site-specific differences in skin response to pathogens and in the course of cutaneous inflammatory diseases are well appreciated. The composition and…”
Get full text

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma by Rindler, Katharina, Jonak, Constanze, Alkon, Natalia, Thaler, Felix M, Kurz, Harald, Shaw, Lisa E, Stingl, Georg, Weninger, Wolfgang, Halbritter, Florian, Bauer, Wolfgang M, Farlik, Matthias, Brunner, Patrick M

“…In early-stage mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, limited skin involvement with patches and plaques is associated with…”
Get full text

Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation by Kirchberger, Stefanie, Shoeb, Mohamed R., Lazic, Daria, Wenninger-Weinzierl, Andrea, Fischer, Kristin, Shaw, Lisa E., Nogueira, Filomena, Rifatbegovic, Fikret, Bozsaky, Eva, Ladenstein, Ruth, Bodenmiller, Bernd, Lion, Thomas, Traver, David, Farlik, Matthias, Schöfer, Christian, Taschner-Mandl, Sabine, Halbritter, Florian, Distel, Martin

“…Neutrophils are evolutionarily conserved innate immune cells playing pivotal roles in host defense. Zebrafish models have contributed substantially to our…”
Get full text

Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8+ T cells by Kamnev, Anton, Mehta, Tanvi, Wielscher, Matthias, Chaves, Beatriz, Lacouture, Claire, Mautner, Anna-Katharina, Shaw, Lisa E., Caldera, Michael, Menche, Jörg, Weninger, Wolfgang P., Farlik, Matthias, Boztug, Kaan, Dupré, Loïc

“…Actin cytoskeleton remodeling sustains the ability of cytotoxic T cells to search for target cells and eliminate them. We here investigated the relationship…”
Get full text

Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells by Rindler, Katharina, Bauer, Wolfgang M, Jonak, Constanze, Wielscher, Matthias, Shaw, Lisa E, Rojahn, Thomas B, Thaler, Felix M, Porkert, Stefanie, Simonitsch-Klupp, Ingrid, Weninger, Wolfgang, Mayerhoefer, Marius E, Farlik, Matthias, Brunner, Patrick M

“…Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. While initially restricted to the skin, malignant cells can appear in blood, bone…”
Get full text

Non-IgE-reactive allergen peptides deteriorate the skin barrier in house dust mite-sensitized atopic dermatitis patients by Pfisterer, Karin, Wielscher, Matthias, Samardzic, David, Weinzettl, Pauline, Symmank, Dorte, Shaw, Lisa E., Campana, Raffaela, Huang, Huey-Jy, Farlik, Matthias, Bangert, Christine, Vrtala, Susanne, Valenta, Rudolf, Weninger, Wolfgang

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by type 2 cytokine-driven skin inflammation and epithelial barrier dysfunction. The…”
Get full text

Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH by Hendrikx, Tim, Porsch, Florentina, Kiss, Máté G., Rajcic, Dragana, Papac-Miličević, Nikolina, Hoebinger, Constanze, Goederle, Laura, Hladik, Anastasiya, Shaw, Lisa E., Horstmann, Hauke, Knapp, Sylvia, Derdak, Sophia, Bilban, Martin, Heintz, Lena, Krawczyk, Marcin, Paternostro, Rafael, Trauner, Michael, Farlik, Matthias, Wolf, Dennis, Binder, Christoph J.

“…Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic…”
Get full text

Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis by Alkon, Natalia, Assen, Frank P., Arnoldner, Tamara, Bauer, Wolfgang M., Medjimorec, Marco A., Shaw, Lisa E., Rindler, Katharina, Holzer, Gregor, Weber, Philipp, Weninger, Wolfgang, Freystätter, Christian, Chennareddy, Sumanth, Kinaciyan, Tamar, Farlik, Matthias, Jonak, Constanze, Griss, Johannes, Bangert, Christine, Brunner, Patrick M.

“…[Display omitted] Chronic nodular prurigo (CNPG) is an inflammatory skin disease that is maintained by a chronic itch-scratch cycle likely rooted in…”
Get full text

Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells by Mayer, Isabella M., Doma, Eszter, Klampfl, Thorsten, Prchal-Murphy, Michaela, Kollmann, Sebastian, Schirripa, Alessia, Scheiblecker, Lisa, Zojer, Markus, Kunowska, Natalia, Gebrail, Lea, Shaw, Lisa E., Mann, Ulrike, Farr, Alex, Grausenburger, Reinhard, Heller, Gerwin, Zebedin-Brandl, Eva, Farlik, Matthias, Malumbres, Marcos, Sexl, Veronika, Kollmann, Karoline

“…•Inhibiting CDK6 kinase function enhances long-term HSC functionality.•Kinase-inactivated CDK6 and MAZ influence HSC maintenance. [Display omitted]…”
Get full text

Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis by Kugler, Maximilian, Dellinger, Mirjam, Kartnig, Felix, Müller, Lena, Preglej, Teresa, Heinz, Leonhard X, Simader, Elisabeth, Göschl, Lisa, Puchner, Stephan E, Weiss, Sebastian, Shaw, Lisa E, Farlik, Matthias, Weninger, Wolfgang, Superti-Furga, Giulio, Smolen, Josef S, Steiner, Guenter, Aletaha, Daniel, Kiener, Hans P, Lewis, Myles J, Pitzalis, Costantino, Tosevska, Anela, Karonitsch, Thomas, Bonelli, Michael

“…Structural reorganisation of the synovium with expansion of fibroblast-like synoviocytes (FLS) and influx of immune cells is a hallmark of rheumatoid arthritis…”
Get more information

Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C) by Bormann, Daniel, Copic, Dragan, Klas, Katharina, Direder, Martin, Riedl, Christian J., Testa, Giulia, Kühtreiber, Hannes, Poreba, Emilia, Hametner, Simon, Golabi, Bahar, Salek, Melanie, Haider, Carmen, Endmayr, Verena, Shaw, Lisa E., Höftberger, Romana, Ankersmit, Hendrik J., Mildner, Michael

“…Peripheral contact to pathogen-associated molecular patterns (PAMPs) evokes a systemic innate immune response which is rapidly relayed to the central nervous…”
Get full text

Single‐cell RNA sequencing analysis of a COVID‐19–associated maculopapular rash in a patient with psoriasis treated with ustekinumab by Rindler, Katharina, Tschandl, Philipp, Levine, Jasmine P., Shaw, Lisa E., Weninger, Wolfgang, Farlik, Matthias, Jonak, Constanze, Brunner, Patrick M.

“…Coronavirus disease 2019 (COVID‐19) primarily affects the respiratory system but extrapulmonary manifestations, including the skin, have been well documented…”
Get full text

Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis by Kostel Bal, Sevgi, Giuliani, Sarah, Block, Jana, Repiscak, Peter, Hafemeister, Christoph, Shahin, Tala, Kasap, Nurhan, Ransmayr, Bernhard, Miao, Yirun, van de Wetering, Cheryl, Frohne, Alexandra, Jimenez Heredia, Raul, Schuster, Michael, Zoghi, Samaneh, Hertlein, Vanessa, Thian, Marini, Bykov, Aleksandr, Babayeva, Royala, Bilgic Eltan, Sevgi, Karakoc-Aydiner, Elif, Shaw, Lisa E, Chowdhury, Iftekhar, Varjosalo, Markku, Argüello, Rafael J, Farlik, Matthias, Ozen, Ahmet, Serfling, Edgar, Dupré, Loïc, Bock, Christoph, Halbritter, Florian, Hannich, J Thomas, Castanon, Irinka, Kraakman, Michael J, Baris, Safa, Boztug, Kaan

“…The nuclear factor of activated T cells (NFAT) family of transcription factors plays central roles in adaptive immunity in murine models; however, their…”
Get full text

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations by Saldana-Guerrero, Ingrid M., Montano-Gutierrez, Luis F., Boswell, Katy, Hafemeister, Christoph, Poon, Evon, Shaw, Lisa E., Stavish, Dylan, Lea, Rebecca A., Wernig-Zorc, Sara, Bozsaky, Eva, Fetahu, Irfete S., Zoescher, Peter, Pötschger, Ulrike, Bernkopf, Marie, Wenninger-Weinzierl, Andrea, Sturtzel, Caterina, Souilhol, Celine, Tarelli, Sophia, Shoeb, Mohamed R., Bozatzi, Polyxeni, Rados, Magdalena, Guarini, Maria, Buri, Michelle C., Weninger, Wolfgang, Putz, Eva M., Huang, Miller, Ladenstein, Ruth, Andrews, Peter W., Barbaric, Ivana, Cresswell, George D., Bryant, Helen E., Distel, Martin, Chesler, Louis, Taschner-Mandl, Sabine, Farlik, Matthias, Tsakiridis, Anestis, Halbritter, Florian

“…Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs…”
Get full text

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma by Rindler, Katharina, Jonak, Constanze, Alkon, Natalia, Thaler, Felix M, Kurz, Harald, Shaw, Lisa E, Stingl, Georg, Weninger, Wolfgang, Halbritter, Florian, Farlik, Matthias, Brunner, Patrick M

Get full text

Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development by Saldana-Guerrero, Ingrid M., Montano-Gutierrez, Luis F., Hafemeister, Christoph, Stavish, Dylan, Shaw, Lisa E., Fetahu, Irfete S., Wenninger-Weinzierl, Andrea, Sturtzel, Caterina, Souilhol, Celine, Tarelli, Sophia, Shoeb, Mohamed R., Bernkopf, Marie, Bozatzi, Polyxeni, Guarini, Maria, Bozsaky, Eva, Buri, Michelle C., Putz, Eva M., Andrews, Peter W., Barbaric, Ivana, Bryant, Helen E., Distel, Martin, Taschner-Mandl, Sabine, Farlik, Matthias, Tsakiridis, Anestis, Halbritter, Florian

“…Early childhood malignancies are driven by sparse genetic aberrations in oncogenes that often co-occur with large copy number variants (CNVs). The combination…”
Get full text