Search Results - "Shaw, Liam"

Null models for gene enrichment in plasmids by Shaw, Liam P.

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No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2 by van Dorp, Lucy, Richard, Damien, Tan, Cedric C. S., Shaw, Liam P., Acman, Mislav, Balloux, François

“…COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human population in late 2019 from a currently uncharacterised animal reservoir. Due to…”
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Restriction-modification systems have shaped the evolution and distribution of plasmids across bacteria by Shaw, Liam P, Rocha, Eduardo P C, MacLean, R Craig

“…Abstract Many novel traits such as antibiotic resistance are spread by plasmids between species. Yet plasmids have different host ranges…”
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The global distribution and spread of the mobilized colistin resistance gene mcr-1 by Wang, Ruobing, van Dorp, Lucy, Shaw, Liam P., Bradley, Phelim, Wang, Qi, Wang, Xiaojuan, Jin, Longyang, Zhang, Qing, Liu, Yuqing, Rieux, Adrien, Dorai-Schneiders, Thamarai, Weinert, Lucy Anne, Iqbal, Zamin, Didelot, Xavier, Wang, Hui, Balloux, Francois

“…Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae . As such, the recent…”
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Emergence of genomic diversity and recurrent mutations in SARS-CoV-2 by van Dorp, Lucy, Acman, Mislav, Richard, Damien, Shaw, Liam P., Ford, Charlotte E., Ormond, Louise, Owen, Christopher J., Pang, Juanita, Tan, Cedric C.S., Boshier, Florencia A.T., Ortiz, Arturo Torres, Balloux, François

“…SARS-CoV-2 is a SARS-like coronavirus of likely zoonotic origin first identified in December 2019 in Wuhan, the capital of China's Hubei province. The virus…”
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Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM by Acman, Mislav, Wang, Ruobing, van Dorp, Lucy, Shaw, Liam P., Wang, Qi, Luhmann, Nina, Yin, Yuyao, Sun, Shijun, Chen, Hongbin, Wang, Hui, Balloux, Francois

“…The mobile resistance gene bla NDM encodes the NDM enzyme which hydrolyses carbapenems, a class of antibiotics used to treat some of the most severe bacterial…”
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The phylogenetic range of bacterial and viral pathogens of vertebrates by Shaw, Liam P., Wang, Alethea D., Dylus, David, Meier, Magda, Pogacnik, Grega, Dessimoz, Christophe, Balloux, François

“…Many major human pathogens are multihost pathogens, able to infect other vertebrate species. Describing the general patterns of host–pathogen associations…”
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High efficiency perovskite quantum dot solar cells with charge separating heterostructure by Zhao, Qian, Hazarika, Abhijit, Chen, Xihan, Harvey, Steve P., Larson, Bryon W., Teeter, Glenn R., Liu, Jun, Song, Tao, Xiao, Chuanxiao, Shaw, Liam, Zhang, Minghui, Li, Guoran, Beard, Matthew C., Luther, Joseph M.

“…Metal halide perovskite semiconductors possess outstanding characteristics for optoelectronic applications including but not limited to photovoltaics…”
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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast by Jeffares, Daniel C., Jolly, Clemency, Hoti, Mimoza, Speed, Doug, Shaw, Liam, Rallis, Charalampos, Balloux, Francois, Dessimoz, Christophe, Bähler, Jürg, Sedlazeck, Fritz J.

“…Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic…”
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From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic by Balloux, Francois, Brønstad Brynildsrud, Ola, van Dorp, Lucy, Shaw, Liam P., Chen, Hongbin, Harris, Kathryn A., Wang, Hui, Eldholm, Vegard

“…Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens…”
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Modelling microbiome recovery after antibiotics using a stability landscape framework by Shaw, Liam P., Bassam, Hassan, Barnes, Chris P., Walker, A. Sarah, Klein, Nigel, Balloux, Francois

“…Treatment with antibiotics is one of the most extreme perturbations to the human microbiome. Even standard courses of antibiotics dramatically reduce the…”
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Children With Cystic Fibrosis Are Infected With Multiple Subpopulations of Mycobacterium abscessus With Different Antimicrobial Resistance Profiles by Shaw, Liam P, Doyle, Ronan M, Kavaliunaite, Ema, Spencer, Helen, Balloux, Francois, Dixon, Garth, Harris, Kathryn A

“…Children with cystic fibrosis (CF) can develop life-threatening infections of Mycobacterium abscessus. These present a significant clinical challenge,…”
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Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings by Ogunlana, Lois, Kaur, Divjot, Shaw, Liam P., Jangir, Pramod, Walsh, Timothy, Uphoff, Stephan, MacLean, R. C.

“…Antibiotic resistance tends to carry fitness costs, making it difficult to understand how resistance can be maintained in the absence of continual antibiotic…”
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Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture by Nimmo, Camus, Shaw, Liam P, Doyle, Ronan, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S

“…Repeated culture reduces within-sample Mycobacterium tuberculosis genetic diversity due to selection of clones suited to growth in culture and/or random loss…”
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Representing antibiotic relationships using measurements of efficacy against clinical isolates by Shaw, Liam

“…Introduction. Antimicrobial resistance (AMR) is a worrying and confusing problem for both patients and medical professionals. It is often difficult for…”
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Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient by Wheatley, Rachel M., Caballero, Julio Diaz, van der Schalk, Thomas E., De Winter, Fien H. R., Shaw, Liam P., Kapel, Natalia, Recanatini, Claudia, Timbermont, Leen, Kluytmans, Jan, Esser, Mark, Lacoma, Alicia, Prat-Aymerich, Cristina, Oliver, Antonio, Kumar-Singh, Samir, Malhotra-Kumar, Surbhi, Craig MacLean, R.

“…Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly…”
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A longitudinal study reveals persistence of antimicrobial resistance on livestock farms is not due to antimicrobial usage alone by Smith, Richard P, May, Hannah E, AbuOun, Manal, Stubberfield, Emma, Gilson, Daniel, Chau, Kevin K, Crook, Derrick W, Shaw, Liam P, Read, Daniel S, Stoesser, Nicole, Vilar, Maria Jose, Anjum, Muna F

“…There are concerns that antimicrobial usage (AMU) is driving an increase in multi-drug resistant (MDR) bacteria so treatment of microbial infections is…”
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Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients by Diaz Caballero, Julio, Wheatley, Rachel M., Kapel, Natalia, López-Causapé, Carla, Van der Schalk, Thomas, Quinn, Angus, Shaw, Liam P., Ogunlana, Lois, Recanatini, Claudia, Xavier, Basil Britto, Timbermont, Leen, Kluytmans, Jan, Ruzin, Alexey, Esser, Mark, Malhotra-Kumar, Surbhi, Oliver, Antonio, MacLean, R. Craig

“…Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed…”
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Oral microbiomes from hunter‐gatherers and traditional farmers reveal shifts in commensal balance and pathogen load linked to diet by Lassalle, Florent, Spagnoletti, Matteo, Fumagalli, Matteo, Shaw, Liam, Dyble, Mark, Walker, Catherine, Thomas, Mark G., Bamberg Migliano, Andrea, Balloux, Francois

“…Maladaptation to modern diets has been implicated in several chronic disorders. Given the higher prevalence of disease such as dental caries and chronic gum…”
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Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China by Chen, Hongbin, Yin, Yuyao, van Dorp, Lucy, Shaw, Liam P, Gao, Hua, Acman, Mislav, Yuan, Jizhen, Chen, Fengning, Sun, Shijun, Wang, Xiaojuan, Li, Shuguang, Zhang, Yawei, Farrer, Rhys A, Wang, Hui, Balloux, Francois

“…Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen subdivided into lineages termed sequence types (STs). Since the 1950s,…”
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