Search Results - "Shaw, Laura A"

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy by Milner, J. Justin, Toma, Clara, He, Zhaoren, Kurd, Nadia S., Nguyen, Quynh P., McDonald, Bryan, Quezada, Lauren, Widjaja, Christella E., Witherden, Deborah A., Crowl, John T., Shaw, Laura A., Yeo, Gene W., Chang, John T., Omilusik, Kyla D., Goldrath, Ananda W.

“…Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing…”
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Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8 + T cells by Omilusik, Kyla D, Nadjsombati, Marija S, Shaw, Laura A, Yu, Bingfei, Milner, J Justin, Goldrath, Ananda W

“…CD8 T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate,…”
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Id3 expression identifies CD4 + memory Th1 cells by Shaw, Laura A, Deng, Tianda Z, Omilusik, Kyla D, Takehara, Kennidy K, Nguyen, Quynh P, Goldrath, Ananda W

“…Memory CD4 T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However,…”
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Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity by Omilusik, Kyla D, Nadjsombati, Marija S, Yoshida, Tomomi M, Shaw, Laura A, Goulding, John, Goldrath, Ananda W

“…T cells are essential mediators of immune responses against infectious diseases and provide long-lived protection from reinfection. The differentiation of…”
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Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory by Omilusik, Kyla D, Shaw, Laura A, Goldrath, Ananda W

“…Highlights • E and ID proteins control many aspects of CD8+ T cell differentiation. • ID2 mediates effector cell survival and differentiation to memory. • ID3…”
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SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking by Dragone, Leonard L, Shaw, Laura A, Myers, Margaret D, Weiss, Arthur

“…Src-like adapter proteins (SLAP and SLAP-2) constitute a family of proteins that are expressed in a variety of cell types but are studied most extensively in…”
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Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation by Shaw, Laura A, Bélanger, Simon, Omilusik, Kyla D, Cho, Sunglim, Scott-Browne, James P, Nance, J Philip, Goulding, John, Lasorella, Anna, Lu, Li-Fan, Crotty, Shane, Goldrath, Ananda W

“…Activation of CD4 + T cells leads to their polarization to various effector states. Goldrath and colleagues identify a role for the E-protein inhibitor Id2 in…”
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SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice by Peterson, Lisa K, Shaw, Laura A, Joetham, Anthony, Sakaguchi, Shimon, Gelfand, Erwin W, Dragone, Leonard L

“…To test if manipulating TCR complex-mediated signaling (TCR signaling) could treat autoimmune disease, we generated the double SKG Src-like adapter protein…”
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SLAP deficiency decreases dsDNA autoantibody production by Peterson, Lisa K, Pennington, Luke F, Shaw, Laura A, Brown, Meredith, Treacy, Eric C, Friend, Samantha F, Hatlevik, Øyvind, Rubtsova, Kira, Rubtsov, Anatoly V, Dragone, Leonard L

“…Abstract Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels and…”
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Pregnancy amelioration of arthritis in SKG mice corresponds with alterations in serum amyloid A3 levels by Shaw, Laura A, Stefanski, Adrianne L, Peterson, Lisa K, Rumer, Kristen K, Vondracek, Andrea, Phang, Tzu L, Sakaguchi, Shimon, Winn, Virginia D, Dragone, Leonard L

“…OBJECTIVES: Pregnancy leads to rheumatoid arthritis remission in humans. The objective of this study was to determine if the SKG mouse could serve as a model…”
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Id2 reinforces [T.sub.H]1 differentiation and inhibits E2A to repress [T.sub.FH] differentiation by Shaw, Laura A, Belanger, Simon, Omilusik, Kyla D, Cho, Sunglim, Scott-Browne, James P, Nance, J. Philip, Goulding, John, Lasorella, Anna, Lu, Li-Fan, Crotty, Shane, Goldrath, Ananda W

“…The differentiation of helper T cells into effector subsets is critical to host protection. Transcription factors of the E-protein and Id families are…”
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Id2 reinforces T sub(H)1 differentiation and inhibits E2A to repress T sub(FH) differentiation by Shaw, Laura A, Belanger, Simon, Omilusik, Kyla D, Cho, Sunglim, Scott-Browne, James P, Nance, J Philip, Goulding, John, Lasorella, Anna, Lu, Li-Fan, Crotty, Shane, Goldrath, Ananda W

“…The differentiation of helper T cells into effector subsets is critical to host protection. Transcription factors of the E-protein and Id families are…”
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Id2 reinforces TH1 cell differentiation and inhibits E2A to repress TFH cell differentiation by Shaw, Laura A., Bélanger, Simon, Omilusik, Kyla D., Cho, Sunglim, Scott-Browne, James P., Nance, J. Philip, Goulding, John, Lasorella, Anna, Lu, Li-Fan, Crotty, Shane, Goldrath, Ananda W.

“…Differentiation of T helper (T H ) effector subsets is critical for host protection. E protein transcription factors and Id proteins are important arbiters of…”
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Src-like adaptor protein (SLAP)-deficiency prevents chronic arthritis in SKG mice (49.7) by Dragone, Leonard, Shaw, Laura A, Sakaguchi, Shimon, Peterson, Lisa K

“…Abstract Background: Intrinsic defects in lymphocyte signaling have been implicated in the pathogenesis of rheumatoid arthritis (RA) by a mouse model of…”
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Src-like adaptor protein (SLAP) deficiency leads to decreased autoantibody production (99.37) by Peterson, Lisa K, Shaw, Laura A, Dragone, Leonard L

“…Abstract Background: Intrinsic defects in lymphocyte signaling have been implicated in the pathogenesis of autoimmunity. SLAP has been shown to influence BCR…”
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Pregnancy-Induced Rheumatoid Arthritis Amelioration in SKG Mice (137.29) by Dragone, Leonard, Shaw, Laura A, Rumer, Kristen K, Kramer, Anita, Sakaguchi, Shimon, Winn, Virginia D

“…Abstract Background: During pregnancy 75% of women with Rheumatoid Arthritis (RA) have amelioration of their disease. The mechanism of pregnancy-induced…”
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SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking: Organization of Immunoreceptor Signaling by Adapters by DRAGONE, Leonard L, SHAW, Laura A, MYERS, Margaret D, WEISS, Arthur

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