Search Results - "Shaw, Karen J."

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome by Polikanov, Yury S., Osterman, Ilya A., Szal, Teresa, Tashlitsky, Vadim N., Serebryakova, Marina V., Kusochek, Pavel, Bulkley, David, Malanicheva, Irina A., Efimenko, Tatyana A., Efremenkova, Olga V., Konevega, Andrey L., Shaw, Karen J., Bogdanov, Alexey A., Rodnina, Marina V., Dontsova, Olga A., Mankin, Alexander S., Steitz, Thomas A., Sergiev, Petr V.

“…We demonstrate that the antibiotic amicoumacin A (AMI) is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the…”
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Results of the Surveillance of Tedizolid Activity and Resistance Program: in vitro susceptibility of Gram-positive pathogens collected in 2011 and 2012 from the United States and Europe by Sahm, Daniel F, Deane, Jennifer, Bien, Paul A, Locke, Jeffrey B, Zuill, Douglas E, Shaw, Karen J, Bartizal, Ken F

“…Abstract The in vitro activity and spectrum of tedizolid and comparators were analyzed against 6884 Gram-positive clinical isolates collected from multiple US…”
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Low Fitness Cost of the Multidrug Resistance Gene cfr by LAMARRE, Jacqueline M, LOCKE, Jeffrey B, SHAW, Karen J, MANKIN, Alexander S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents by Tari, Leslie W, Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Castellano, Amanda, Locke, Jeff B, Brown-Driver, Vickie, Murphy, Timothy M, Ong, Voon S, Pillar, Chris M, Shinabarger, Dean L, Nix, Jay, Lightstone, Felice C, Wong, Sergio E, Nguyen, Toan B, Shaw, Karen J, Finn, John

“…Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a…”
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Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens by Liston, Sean D., Whitesell, Luke, Kapoor, Mili, Shaw, Karen J., Cowen, Leah E.

“…Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug…”
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In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris by Hager, Christopher L, Larkin, Emily L, Long, Lisa, Zohra Abidi, Fatima, Shaw, Karen J, Ghannoum, Mahmoud A

“…is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. strains often…”
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Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis by Alkhazraji, Sondus, Gebremariam, Teclegiorgis, Alqarihi, Abdullah, Gu, Yiyou, Mamouei, Zeinab, Singh, Shakti, Wiederhold, Nathan P, Shaw, Karen J, Ibrahim, Ashraf S

“…There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to and Manogepix (MGX; APX001A) is a novel…”
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APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis by Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Alqarihi, Abdullah, Jeon, Heewon H, Gu, Yiyou, Kapoor, Mili, Shaw, Karen J, Ibrahim, Ashraf S

“…Invasive pulmonary aspergillosis (IPA) due to is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new…”
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Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers by Hodges, Michael R, Ople, Eric, Wedel, Pamela, Shaw, Karen J, Jakate, Abhijeet, Kramer, William G, Marle, Sjoerd van, van Hoogdalem, Ewoud-Jan, Tawadrous, Margaret

“…Fosmanogepix (FMGX, APX001), a first-in-class, intravenous (i.v.) and oral (p.o.) antifungal prodrug candidate is currently in clinical development for the…”
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Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis by Wiederhold, Nathan P, Najvar, Laura K, Shaw, Karen J, Jaramillo, Rosie, Patterson, Hoja, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F

“…The emerging pathogenic yeast is associated with antifungal resistance and high mortality. The novel antifungal agent manogepix (APX001A) inhibits…”
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Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes by Badali, Hamid, Patterson, Hoja P, Sanders, Carmita J, Mermella, Barbara, Gibas, Connie F C, Ibrahim, Ashraf S, Shaw, Karen J, Wiederhold, Nathan P

“…We evaluated the activity of manogepix against and species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods…”
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Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition by Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J, Vázquez-Laslop, Nora, Mankin, Alexander S

“…Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery…”
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Detection of the High-Level Aminoglycoside Resistance Gene aph(2")-Ib in Enterococcus faecium by KAO, Susan J, IL YOU, CLEWELL, Don B, DONABEDIAN, Susan M, ZERVOS, Marcus J, PETRIN, Joanne, SHAW, Karen J, CHOW, Joseph W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity by Tari, Leslie W., Trzoss, Michael, Bensen, Daniel C., Li, Xiaoming, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Creighton, Christopher J., Cunningham, Mark L., Kwan, Bryan, Stidham, Mark, Shaw, Karen J., Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Nix, Jay, Finn, John

“…The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication…”
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Analysis of Commercial Kidney Stone Probiotic Supplements by Ellis, Melissa L, Shaw, Karen J, Jackson, Shelby B, Daniel, Steven L, Knight, John

“…Objective To examine the levels of Oxalobacter formigenes in probiotic supplements marketed by PRO-LAB, Ltd, Toronto, Canada, and capsules of Oxalo purchased…”
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity by Trzoss, Micheal, Bensen, Daniel C., Li, Xiaoming, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Creighton, Christopher J., Cunningham, Mark L., Kwan, Bryan, Stidham, Mark, Nelson, Kirk, Brown-Driver, Vickie, Castellano, Amanda, Shaw, Karen J., Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Finn, John, Tari, Leslie W.

“…The structurally related bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) have long been recognized as prime candidates for the…”
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Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design by Teng, Min, Hilgers, Mark T, Cunningham, Mark L, Borchardt, Allen, Locke, Jeffrey B, Abraham, Sunny, Haley, Gregory, Kwan, Bryan P, Hall, Courtney, Hough, Grayson W, Shaw, Karen J, Finn, John

“…A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds…”
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Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene by Locke, Jeffrey B, Zuill, Douglas E, Scharn, Caitlyn R, Deane, Jennifer, Sahm, Daniel F, Denys, Gerald A, Goering, Richard V, Shaw, Karen J

“…The Cfr methyltransferase confers resistance to six classes of drugs which target the peptidyl transferase center of the 50S ribosomal subunit, including some…”
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Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center by Locke, Jeffrey B, Zuill, Douglas E, Scharn, Caitlyn R, Deane, Jennifer, Sahm, Daniel F, Goering, Richard V, Jenkins, Stephen G, Shaw, Karen J

“…The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a…”
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Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines by Li, Xiaoming, Hilgers, Mark, Cunningham, Mark, Chen, Zhiyong, Trzoss, Michael, Zhang, Junhu, Kohnen, Lucy, Lam, Thanh, Creighton, Chris, GC, Kedar, Nelson, Kirk, Kwan, Bryan, Stidham, Mark, Brown-Driver, Vickie, Shaw, Karen J., Finn, John

“…Dihydrofolate reductase (DHFR) inhibitors such as trimethoprim (TMP) have long played a significant role in the treatment of bacterial infections. Not…”
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