Search Results - "Shaw, George M."

HIV-Host Interactions: Implications for Vaccine Design by Haynes, Barton F., Shaw, George M., Korber, Bette, Kelsoe, Garnett, Sodroski, Joseph, Hahn, Beatrice H., Borrow, Persephone, McMichael, Andrew J.

“…Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity…”
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Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages by OCHSENBAUER, Christina, EDMONDS, Tara G, HAHN, Beatrice H, KAPPES, John C, HAITAO DING, KEELE, Brandon F, DECKER, Julie, SALAZAR, Maria G, SALAZAR-GONZALEZ, Jesus F, SHATTOCK, Robin, HAYNES, Barton F, SHAW, George M

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Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness by Iyer, Shilpa S., Bibollet-Ruche, Frederic, Sherrill-Mix, Scott, Learn, Gerald H., Plenderleith, Lindsey, Smith, Andrew G., Barbian, Hannah J., Russell, Ronnie M., Gondim, Marcos V. P., Bahari, Catherine Y., Shaw, Christiana M., Li, Yingying, Decker, Timothy, Haynes, Barton F., Shaw, George M., Sharp, Paul M., Borrow, Persephone, Hahn, Beatrice H.

“…Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and…”
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Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria by Sundararaman, Sesh A., Plenderleith, Lindsey J., Liu, Weimin, Loy, Dorothy E., Learn, Gerald H., Li, Yingying, Shaw, Katharina S., Ayouba, Ahidjo, Peeters, Martine, Speede, Sheri, Shaw, George M., Bushman, Frederic D., Brisson, Dustin, Rayner, Julian C., Sharp, Paul M., Hahn, Beatrice H.

“…African apes harbour at least six Plasmodium species of the subgenus Laverania , one of which gave rise to human Plasmodium falciparum . Here we use a…”
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HIV-1 Vpu Mediates HLA-C Downregulation by Apps, Richard, Del Prete, Gregory Q., Chatterjee, Pramita, Lara, Abigail, Brumme, Zabrina L., Brockman, Mark A., Neil, Stuart, Pickering, Suzanne, Schneider, Douglas K., Piechocka-Trocha, Alicja, Walker, Bruce D., Thomas, Rasmi, Shaw, George M., Hahn, Beatrice H., Keele, Brandon F., Lifson, Jeffrey D., Carrington, Mary

“…Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis…”
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Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection by Kinchen, Valerie J., Zahid, Muhammad N., Flyak, Andrew I., Soliman, Mary G., Learn, Gerald H., Wang, Shuyi, Davidson, Edgar, Doranz, Benjamin J., Ray, Stuart C., Cox, Andrea L., Crowe, James E., Bjorkman, Pamela J., Shaw, George M., Bailey, Justin R.

“…The role that broadly neutralizing antibodies (bNAbs) play in natural clearance of human hepatitis C virus (HCV) infection and the underlying mechanisms remain…”
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Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication by Giugliano, Silvia, Kriss, Michael, Golden-Mason, Lucy, Dobrinskikh, Evgenia, Stone, Amy E.L, Soto-Gutierrez, Alejandro, Mitchell, Angela, Khetani, Salman R, Yamane, Daisuke, Stoddard, Mark, Li, Hui, Shaw, George M, Edwards, Michael G, Lemon, Stanley M, Gale, Michael, Shah, Vijay H, Rosen, Hugo R

“…Background & Aims Liver sinusoidal endothelial cells (LSECs) make up a large proportion of the nonparenchymal cells in the liver. LSECs are involved in…”
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Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection by Song, Hongshuo, Giorgi, Elena E., Ganusov, Vitaly V., Cai, Fangping, Athreya, Gayathri, Yoon, Hyejin, Carja, Oana, Hora, Bhavna, Hraber, Peter, Romero-Severson, Ethan, Jiang, Chunlai, Li, Xiaojun, Wang, Shuyi, Li, Hui, Salazar-Gonzalez, Jesus F., Salazar, Maria G., Goonetilleke, Nilu, Keele, Brandon F., Montefiori, David C., Cohen, Myron S., Shaw, George M., Hahn, Beatrice H., McMichael, Andrew J., Haynes, Barton F., Korber, Bette, Bhattacharya, Tanmoy, Gao, Feng

“…Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of within-host diversification is less understood. Here we develop a…”
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An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum by FERRARI, Guido, POLLARA, Justin, KAPPES, John C, SHAW, George M, HOXIE, James A, ROBINSON, James E, HAYNES, Barton F, KOZINK, Daniel, HARMS, Tiara, DRINKER, Mark, FREEL, Stephanie, MOODY, M. Anthony, MUNIR ALAM, S, TOMARAS, Georgia D, OCHSENBAUER, Christina

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Viral Envelope Evolution in Simian-HIV-Infected Neonate and Adult-Dam Pairs of Rhesus Macaques by Giorgi, Elena E, Li, Hui, Hora, Bhavna, Shaw, George M, Wagh, Kshitij, Williams, Wilton B

“…We recently demonstrated that Simian-HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with…”
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Relative resistance of HIV-1 founder viruses to control by interferon-alpha by Fenton-May, Angharad E, Dibben, Oliver, Emmerich, Tanja, Ding, Haitao, Pfafferott, Katja, Aasa-Chapman, Marlen M, Pellegrino, Pierre, Williams, Ian, Cohen, Myron S, Gao, Feng, Shaw, George M, Hahn, Beatrice H, Ochsenbauer, Christina, Kappes, John C, Borrow, Persephone

“…Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication…”
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Broad HIV-1 neutralization mediated by CD4-binding site antibodies by Wyatt, Richard T, Li, Yuxing, Migueles, Stephen A, Welcher, Brent, Svehla, Krisha, Phogat, Adhuna, Louder, Mark K, Wu, Xueling, Shaw, George M, Connors, Mark, Mascola, John R

“…We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the…”
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Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing by Salazar-Gonzalez, Jesus F, Bailes, Elizabeth, Pham, Kimmy T, Salazar, Maria G, Guffey, M Brad, Keele, Brandon F, Derdeyn, Cynthia A, Farmer, Paul, Hunter, Eric, Allen, Susan, Manigart, Olivier, Mulenga, Joseph, Anderson, Jeffrey A, Swanstrom, Ronald, Haynes, Barton F, Athreya, Gayathri S, Korber, Bette T M, Sharp, Paul M, Shaw, George M, Hahn, Beatrice H

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Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth by Wagh, Kshitij, Kreider, Edward F., Li, Yingying, Barbian, Hannah J., Learn, Gerald H., Giorgi, Elena, Hraber, Peter T., Decker, Timothy G., Smith, Andrew G., Gondim, Marcos V., Gillis, Lindsey, Wandzilak, Jamie, Chuang, Gwo-Yu, Rawi, Reda, Cai, Fangping, Pellegrino, Pierre, Williams, Ian, Overbaugh, Julie, Gao, Feng, Kwong, Peter D., Haynes, Barton F., Shaw, George M., Borrow, Persephone, Seaman, Michael S., Hahn, Beatrice H., Korber, Bette

“…Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can…”
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Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection by GANUSOV, Vitaly V, GOONETILLEKE, Nilu, LIU, Michael K. P, FERRARI, Guido, SHAW, George M, MCMICHAEL, Andrew J, BORROW, Persephone, KORBER, Bette T, PERELSON, Alan S

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Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals by YUXING LI, SVEHLA, Krisha, CONNORS, Mark, HOXIE, James, MASCOLA, John R, WYATT, Richard, LOUDER, Mark K, WYCUFF, Diane, PHOGAT, Sanjay, MIN TANG, MIGUELES, Stephen A, XUELING WU, PHOGAT, Adhuna, SHAW, George M

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Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potency by Frumento, Nicole, Figueroa, Alexis, Wang, Tingchang, Zahid, Muhammad N, Wang, Shuyi, Massaccesi, Guido, Stavrakis, Georgia, Crowe, Jr, James E, Flyak, Andrew I, Ji, Hongkai, Ray, Stuart C, Shaw, George M, Cox, Andrea L, Bailey, Justin R

“…A prophylactic hepatitis C virus (HCV) vaccine that elicits neutralizing antibodies could be key to HCV eradication. However, the genetic and antigenic…”
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HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC by Wood, Natasha, Bhattacharya, Tanmoy, Keele, Brandon F, Giorgi, Elena, Liu, Michael, Gaschen, Brian, Daniels, Marcus, Ferrari, Guido, Haynes, Barton F, McMichael, Andrew, Shaw, George M, Hahn, Beatrice H, Korber, Bette, Seoighe, Cathal

“…The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced…”
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Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate by Ribeiro, Ruy M, Li, Hui, Wang, Shuyi, Stoddard, Mark B, Learn, Gerald H, Korber, Bette T, Bhattacharya, Tanmoy, Guedj, Jeremie, Parrish, Erica H, Hahn, Beatrice H, Shaw, George M, Perelson, Alan S

“…Hepatitis C virus (HCV) is present in the host with multiple variants generated by its error prone RNA-dependent RNA polymerase. Little is known about the…”
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The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection by Charles, Tysheena P, Burton, Samantha L, Arunachalam, Prabhu S, Cottrell, Christopher A, Sewall, Leigh M, Bollimpelli, Venkata S, Gangadhara, Sailaja, Dey, Antu K, Ward, Andrew B, Shaw, George M, Hunter, Eric, Amara, Rama R, Pulendran, Bali, van Gils, Marit J, Derdeyn, Cynthia A

“…Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that…”
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