Search Results - "Shaw, Gary S."

RBR E3 ubiquitin ligases: new structures, new insights, new questions by Spratt, Donald E, Walden, Helen, Shaw, Gary S

“…The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex…”
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Role of calcium-sensor proteins in cell membrane repair by Li, ZiWei, Shaw, Gary S

“…Cell membrane repair is a critical process used to maintain cell integrity and survival from potentially lethal chemical, and mechanical membrane injury. Rapid…”
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Autoregulation of Parkin activity through its ubiquitin-like domain by Chaugule, Viduth K, Burchell, Lynn, Barber, Kathryn R, Sidhu, Ateesh, Leslie, Simon J, Shaw, Gary S, Walden, Helen

“…Parkin is an E3‐ubiquitin ligase belonging to the RBR (RING–InBetweenRING–RING family), and is involved in the neurodegenerative disorder Parkinson's disease…”
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Calcium-dependent and -independent interactions of the S100 protein family by Santamaria-Kisiel, Liliana, Rintala-Dempsey, Anne C, Shaw, Gary S

“…The S100 proteins comprise at least 25 members, forming the largest group of EF-hand signalling proteins in humans. Although the proteins are expressed in many…”
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Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis by Kumar, Atul, Aguirre, Jacob D, Condos, Tara EC, Martinez-Torres, R Julio, Chaugule, Viduth K, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Mercier, Pascal, Knebel, Axel, Spratt, Donald E, Barber, Kathryn R, Shaw, Gary S, Walden, Helen

“…The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encodes parkin, an E3 ubiquitin ligase of the RBR family. Parkin…”
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Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity by Kumar, Atul, Chaugule, Viduth K, Condos, Tara E C, Barber, Kathryn R, Johnson, Clare, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Knebel, Axel, Shaw, Gary S, Walden, Helen

“…The human RBR E3 ligase Parkin is captured in complex with phosphoubiquitin, revealing a cryptic ubiquitin-binding site and indicating a mechanism of…”
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Acetylation, Phosphorylation, Ubiquitination (Oh My!): Following Post-Translational Modifications on the Ubiquitin Road by Lacoursiere, Rachel E, Hadi, Dania, Shaw, Gary S

“…Ubiquitination is controlled by a series of E1, E2, and E3 enzymes that can ligate ubiquitin to cellular proteins and dictate the turnover of a substrate and…”
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The S100A10-Annexin A2 Complex Provides a Novel Asymmetric Platform for Membrane Repair by Rezvanpour, Atoosa, Santamaria-Kisiel, Liliana, Shaw, Gary S.

“…Membrane repair is mediated by multiprotein complexes, such as that formed between the dimeric EF-hand protein S100A10, the calcium- and phospholipid-binding…”
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Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation by Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S

“…The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early‐onset Parkinson's disease. Parkin is…”
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Structural and Functional Insights into GID/CTLH E3 Ligase Complexes by Maitland, Matthew E R, Lajoie, Gilles A, Shaw, Gary S, Schild-Poulter, Caroline

“…Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules…”
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Switching on ubiquitylation by phosphorylating a ubiquitous activator by Shaw, Gary S

“…The dysfunction of the E3 ubiquitin ligase Parkin is a key contributor to the development of early-onset Parkinson's disease. Parkin is responsible for the…”
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A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease by Spratt, Donald E., Julio Martinez-Torres, R, Noh, Yeong J., Mercier, Pascal, Manczyk, Noah, Barber, Kathryn R., Aguirre, Jacob D., Burchell, Lynn, Purkiss, Andrew, Walden, Helen, Shaw, Gary S.

“…Mutations in the park2 gene, encoding the RING-inBetweenRING-RING E3 ubiquitin ligase parkin, cause 50% of autosomal recessive juvenile Parkinsonism cases…”
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Suramin inhibits cullin-RING E3 ubiquitin ligases by Wu, Kenneth, Chong, Robert A., Yu, Qing, Bai, Jin, Spratt, Donald E., Ching, Kevin, Lee, Chan, Miao, Haibin, Tappin, Inger, Hurwitz, Jerard, Zheng, Ning, Shaw, Gary S., Sun, Yi, Felsenfeld, Dan P., Sanchez, Roberto, Zheng, Jun-nian, Pan, Zhen-Qiang

“…Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to…”
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Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin by Hristova, Ventzislava A., Beasley, Steven A., Rylett, R. Jane, Shaw, Gary S.

“…Missense mutations in park2, encoding the parkin protein, account for ∼50% of autosomal recessive juvenile Parkinson disease (ARJP) cases. Parkin belongs to…”
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Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG by Grishin, Andrey M., Condos, Tara E.C., Barber, Kathryn R., Campbell-Valois, François-Xavier, Parsot, Claude, Shaw, Gary S., Cygler, Miroslaw

“…Shigella invasion of its human host is assisted by T3SS-delivered effector proteins. The OspG effector kinase binds ubiquitin and ubiquitin-loaded…”
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Architecture of the catalytic HPN motif is conserved in all E2 conjugating enzymes by Cook, Benjamin W, Shaw, Gary S

“…E2 conjugating enzymes are the central enzymes in the ubiquitination pathway and are responsible for the transfer of ubiquitin and ubiquitin-like proteins on…”
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Optimized transformation, overexpression and purification of S100A10 by Yan, Xiaolin, Lebel-Beaucage, Marie-France, Tremblay, Samuel, Cantin, Line, Shaw, Gary S, Boisselier, Elodie

“…As a member of the S100 protein family, S100A10 has already been purified. However, its purity, or even yield, have often not been reported in the literature…”
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The Structure of the UbcH8−Ubiquitin Complex Shows a Unique Ubiquitin Interaction Site by Serniwka, Stephanie A, Shaw, Gary S

“…Ubiquitin-mediated proteolysis utilizes a series of three key enzymes (E1, E2, and E3) to transfer and then covalently modify a substrate with ubiquitin. E2…”
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Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase by Spratt, Donald E., Wu, Kenneth, Kovacev, Jordan, Pan, Zhen-Qiang, Shaw, Gary S.

“…RING E3 ligases are proteins that must selectively recruit an E2-conjugating enzyme and facilitate ubiquitin transfer to a substrate. It is not clear how a…”
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Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor by TODOROVIC, Biljana, HUNG, Katherine, MASSIMI, Paola, AVVAKUMOV, Nikita, DICK, Frederick A, SHAW, Gary S, BANKS, Lawrence, MYMRYK, Joe S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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