Search Results - "Shaw, Barbara Ramsay"

Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-L-tryptophanyltriphosphates by Xu, Zhihong, Ramsay Shaw, Barbara

“…Phosphorus-modified prodrugs of dideoxynucleoside triphosphates (ddNTPs) have shown promise as pronucleotide strategies for improving antiviral activity…”
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RNA interference using boranophosphate siRNAs: structure–activity relationships by Hall, Allison H. S., Wan, Jing, Shaughnessy, Erin E., Ramsay Shaw, Barbara, Alexander, Kenneth A.

“…In RNA interference (RNAi), short double-stranded RNA (known as siRNA) inhibits expression from homologous genes. Clinical or pre-clinical use of siRNAs is…”
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Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: Effects on cellular uptake, binding to target sequences, and biologic actions by ASTRIAB-FISHER, Anna, SERGUEEV, Dimitri, FISHER, Michael, SHAW, Barbara Ramsay, JULIANO, R. L

“…The attainment of effective intracellular delivery remains an important issue for pharmacologic applications of antisense oligonucleotides. Here, we describe…”
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Nucleoside and Oligonucleoside Boranophosphates:  Chemistry and Properties by Li, Ping, Sergueeva, Zinaida A, Dobrikov, Mikhail, Shaw, Barbara Ramsay

“…The properties of nucleoside and oligonucleoside boranophosphates are investigated. The spectroscoptic properties and synthesis of such compounds are also…”
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Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide by Li, Ping, Shaw, Barbara Ramsay

“…The first examples of a borane-containing doubly P-modified chiral cyclic nucleoside monophosphate (cNMP), e.g., thymidine and 5-fluoro-2'-deoxyuridine…”
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Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: Exploring a potential strategy for mechanism-based HCV drug design by Cheek, Marcus Adrian, Sharaf, Mariam L., Dobrikov, Mikhail I., Shaw, Barbara Ramsay

“…► α-P-BH3 modification increased incorporation of ribose modified ATP by HCV NS5BΔ55. ► Rp-ATPαB is a better substrate of HCV NS5BΔ55 RdRP than ATP. ► The…”
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Boron-containing nucleic acids. 2. Synthesis of oligodeoxynucleoside boranophosphates by Sood, Anup, Shaw, Barbara Ramsay, Spielvogel, Bernard F

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High potency silencing by single-stranded boranophosphate siRNA by Hall, Allison H. S., Wan, Jing, Spesock, April, Sergueeva, Zinaida, Shaw, Barbara Ramsay, Alexander, Kenneth A.

“…In RNA interference (RNAi), double-stranded short interfering RNA (ds-siRNA) inhibits expression from complementary mRNAs. Recently, it was demonstrated that…”
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RNase H Activation by Stereoregular Boranophosphate Oligonucleotide by Wang, Xin, Dobrikov, Mikhail, Sergueev, Dmitri, Ramsay Shaw, Barbara

“…A stereoregular all-(S p )-boranophosphate oligodeoxyribonucleotide (BH 3 − -ODN) 15-mer was synthesized using an enzymatic approach. The BH 3 − -ODN formed a…”
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Antisense inhibition of P-glycoprotein expression using peptide–oligonucleotide conjugates by Astriab-Fisher, Anna, Sergueev, Dimitri S, Fisher, Michael, Ramsay Shaw, Barbara, Juliano, Rudolph L

“…Antisense oligonucleotides are potentially a powerful tool for the therapeutic manipulation of genes associated with cancer. However, pharmacological…”
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Accelerated Deamination of Cytosine Residues in UV-Induced Cyclobutane Pyrimidine Dimers Leads to CC→TT Transitions by Peng, Wu, Shaw, Barbara Ramsay

“…The rate of UV-induced deamination of cytosine to uracil at a specific site in double-stranded (ds) DNA was monitored using a genetic reversion assay…”
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A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy by Frederico, Lisa A, Kunkel, Thomas A, Shaw, Barbara Ramsay

“…Previously it has not been possible to determine the rate of deamination of cytosine in DNA at 37 degrees C because this reaction occurs so slowly. We describe…”
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Phosphorus deprotonation by a non-nucleophilic base is critical for the synthesis of nucleoside α-P-boranodiphosphates via a phosphoramidite approach by Xu, Zhihong, Shaw, Barbara Ramsay

“…Here we report the synthesis of nucleoside α-P-boranodiphosphate analogs via our improved phosphoramidite approach, where the addition of a non-nucleophilic…”
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DNA Sequence Recognition by the Antitumor Drug Ditercalinium by Crow, Stephen D. G, Bailly, Christian, Garbay-Jaureguiberry, Christiane, Roques, Bernard, Ramsay Shaw, Barbara, Waring, Michael J

“…The antitumor drug ditercalinium is a rare example of a noncovalent DNA-binding ligand that forms bisintercalation complexes via the major groove of the double…”
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Structural Studies of a Borane-Modified Phosphate Diester Linkage:  Ab Initio Calculations on the Dimethylboranophosphate Anion and the Single-Crystal X-ray Structure of Its Diisopropylammonium Salt by Summers, Jack S, Roe, Diana, Boyle, Paul D, Colvin, Michael, Shaw, Barbara Ramsay

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Synthesis of Boron-Containing ADP and GDP Analogues: Nucleoside 5′-(Pα-Boranodiphosphates) by Lin, Jinlai, He, Kaizhang, Ramsay Shaw, Barbara

“…New 5′‐(Pα‐boronated) analogues of the naturally occurring nucleoside diphosphates ADP and GDP were synthesized in good yields, i.e., adenosine…”
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Evaluating the Specificity of Antisense Oligonucleotide Conjugates by Fisher, Anna Astriab, Ye, Dongjiu, Sergueev, Dimitri S., Fisher, Michael H., Shaw, Barbara Ramsay, Juliano, Rudolph L.

“…Antisense oligonucleotides are potentially powerful tools for selective control of cellular and viral gene expression. Crucial to successful application of…”
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Conformational studies of dithymidine boranomonophosphate diastereoisomers by Li, Hong, Huang, Faqing, Shaw, Barbara Ramsay

“…The boranophosphate ester nucleotides are a new class of nucleic acid analogues that are isoelectronic and isostructural to normal phosphodiester nucleic acids…”
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SYNTHESIS OF NEW CLASSES OF BORON-CONTAINING NUCLEOTIDES by Lin, Jinlai, Shaw, Barbara Ramsay

“…Four different types of boron-modified nucleotides are reported: P-boranophos-phorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and…”
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Individual Isomers of Dinucleoside Boranophosphates as Synthons for Incorporation into Oligonucleotides: Synthesis and Configurational Assignment by Sergueeva, Zinaida A., Sergueev, Dmitri S., Ribeiro, Anthony A., Summers, Jack S., Ramsay Shaw, Barbara

“…Individual isomers of the protected boranophosphates 5a and 5b, i.e., the N6‐benzyl‐2′‐deoxy‐5′‐O‐(4,4′‐dimethoxytrityl)adenosin‐3′‐yl…”
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