Search Results - "Shaw, Alisa E."

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain by Flynn, Kevin C., Hellal, Farida, Neukirchen, Dorothee, Jacob, Sonja, Tahirovic, Sabina, Dupraz, Sebastian, Stern, Sina, Garvalov, Boyan K., Gurniak, Christine, Shaw, Alisa E., Meyn, Liane, Wedlich-Söldner, Roland, Bamburg, James R., Small, J. Victor, Witke, Walter, Bradke, Frank

“…Neurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons…”
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An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons by Cast, Thomas P, Boesch, Daniel J, Smyth, Kim, Shaw, Alisa E, Ghebrial, Michael, Chanda, Soham

“…Neuroligins (NLGNs) are a class of postsynaptic cell adhesion molecules that interact with presynaptic neurexins (NRXNs) and regulate synapse function. NLGN4…”
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Cofilactin rod formation mediates inflammation-induced neurite degeneration by Uruk, Gökhan, Mocanu, Ebony, Shaw, Alisa E., Bamburg, James R., Swanson, Raymond A.

“…Stroke, trauma, and neurodegenerative disorders cause loss of neurites (axons and dendrites) in addition to neuronal death. Neurite loss may result directly…”
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Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism by Smith, Lisa K, Babcock, Isaac W, Minamide, Laurie S, Shaw, Alisa E, Bamburg, James R, Kuhn, Thomas B

“…Nearly 50% of individuals with long-term HIV infection are affected by the onset of progressive HIV-associated neurocognitive disorders (HAND). HIV infiltrates…”
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ADF/Cofilin Regulates Actomyosin Assembly through Competitive Inhibition of Myosin II Binding to F-Actin by Wiggan, O'Neil, Shaw, Alisa E., DeLuca, Jennifer G., Bamburg, James R.

“…The contractile actin cortex is important for diverse fundamental cell processes, but little is known about how the assembly of F-actin and myosin II motors is…”
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Cofilin-actin rod formation in neuronal processes after brain ischemia by Won, Seok Joon, Minnella, Angela M, Wu, Long, Eun, Claire H, Rome, Eric, Herson, Paco S, Shaw, Alisa E, Bamburg, James R, Swanson, Raymond A

“…Functional impairment after brain ischemia results in part from loss of neuronal spines and dendrites, independent of neuronal death. Cofilin-actin rods are…”
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Growth cone‐like waves transport actin and promote axonogenesis and neurite branching by Flynn, Kevin C., Pak, Chi W., Shaw, Alisa E., Bradke, Frank, Bamburg, James R.

“…Axonogenesis involves a shift from uniform delivery of materials to all neurites to preferential delivery to the putative axon, supporting its more rapid…”
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Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells by Chiu, Tim Ting, Patel, Nish, Shaw, Alisa E, Bamburg, James R, Klip, Amira

“…GLUT4 vesicles are actively recruited to the muscle cell surface upon insulin stimulation. Key to this process is Rac-dependent reorganization of filamentous…”
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Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons by Walsh, Keifer P, Minamide, Laurie S, Kane, Sarah J, Shaw, Alisa E, Brown, David R, Pulford, Bruce, Zabel, Mark D, Lambeth, J David, Kuhn, Thomas B, Bamburg, James R

“…Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function…”
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Chemokine Receptor Antagonists Prevent and Reverse Cofilin-Actin Rod Pathology and Protect Synapses in Cultured Rodent and Human iPSC-Derived Neurons by Kuhn, Thomas B, Minamide, Laurie S, Tahtamouni, Lubna H, Alderfer, Sydney A, Walsh, Keifer P, Shaw, Alisa E, Yanouri, Omar, Haigler, Henry J, Ruff, Michael R, Bamburg, James R

“…Synapse loss is the principal cause of cognitive decline in Alzheimer's disease (AD) and related disorders (ADRD). Synapse development depends on the intricate…”
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A genetically encoded reporter for real-time imaging of cofilin-actin rods in living neurons by Mi, Jianjie, Shaw, Alisa E, Pak, Chi W, Walsh, Keifer P, Minamide, Laurie S, Bernstein, Barbara W, Kuhn, Thomas B, Bamburg, James R

“…Filament bundles (rods) of cofilin and actin (1:1) form in neurites of stressed neurons where they inhibit synaptic function. Live-cell imaging of rod…”
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Brain-Derived Neurotrophic Factor Regulation of Retinal Growth Cone Filopodial Dynamics Is Mediated through Actin Depolymerizing Factor/Cofilin by Gehler, Scott, Shaw, Alisa E, Sarmiere, Patrick D, Bamburg, James R, Letourneau, Paul C

“…The molecular mechanisms by which neurotrophins regulate growth cone motility are not well understood. This study investigated the signaling involved in…”
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Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders by Shaw, Alisa E, Bamburg, James R

“…Cofilin is a ubiquitous protein which cooperates with many other actin-binding proteins in regulating actin dynamics. Cofilin has essential functions in…”
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Revised mechanism of hydroxyurea-induced cell cycle arrest and an improved alternative by Shaw, Alisa E, Mihelich, Mattias N, Whitted, Jackson E, Reitman, Hannah J, Timmerman, Adam J, Tehseen, Muhammad, Hamdan, Samir M, Schauer, Grant D

“…Replication stress describes endogenous and exogenous challenges to DNA replication in the S-phase. Stress during this critical process causes…”
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Incorporation of cofilin into rods depends on disulfide intermolecular bonds: implications for actin regulation and neurodegenerative disease by Bernstein, Barbara W, Shaw, Alisa E, Minamide, Laurie S, Pak, Chi W, Bamburg, James R

“…Rod-shaped aggregates ("rods"), containing equimolar actin and the actin dynamizing protein cofilin, appear in neurons following a wide variety of potentially…”
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Biochemical and single-molecule techniques to study accessory helicase resolution of R-loop proteins at stalled replication forks by Shaw, Alisa E, Kairamkonda, Sreeya, Ghodke, Harshad, Schauer, Grant D

“…R-loop proteins present a stable and robust blockade to the progression of a DNA replication fork during S-phase. The consequences of this block can include…”
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Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System by Fixman, Benjamin B, Babcock, Isaac W, Minamide, Laurie S, Shaw, Alisa E, Oliveira da Silva, Marina I, Runyan, Avery M, Maloney, Michael T, Field, Jeffrey J, Bamburg, James R

“…Cultured rodent brain slices are useful for studying the cellular and molecular behavior of neurons and glia in an environment that maintains many of their…”
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Heat shock response of warm-incubated barley aleurone layers by Shaw, Alisa E, Brodl, Mark R

“…Heat shock suppresses secretory protein synthesis in$GA_3-stimulated$barley (Hordeum vulgare cv. Himalaya) aleurone layers by selectively destabilizing their…”
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Essential requirement for Rho family GTPase signaling in Pax3 induced mesenchymal–epithelial transition by Wiggan, O'Neil, Shaw, Alisa E., Bamburg, James R.

“…We previously showed that the transcription factor Pax3 regulates mesenchymal-to-epithelial transition (MET) in cultured osteogenic Saos-2 cells. Herein we…”
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Cross-reactivity of antibodies to actin- depolymerizing factor/cofilin family proteins and identification of the major epitope recognized by a mammalian actin-depolymerizing factor/cofilin antibody by Shaw, Alisa E., Minamide, Laurie S., Bill, Christine L., Funk, Janel D., Maiti, Sankar, Bamburg, James R.

“…Members of the actin‐depolymerizing factor (ADF)/cofilin family of proteins are expressed in all eukaryotic cells. In higher vertebrates, cells often express…”
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