Search Results - "Shaw, Alexander D."

Modulation of long-term potentiation following microdoses of LSD captured by thalamo-cortical modelling in a randomised, controlled trial by Murphy, Robin J, Godfrey, Kate, Shaw, Alexander D, Muthukumaraswamy, Suresh, Sumner, Rachael L

“…Microdosing psychedelics is a phenomenon with claimed cognitive benefits that are relatively untested clinically. Pre-clinically, psychedelics have…”
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Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine by Shaw, Alexander D, Muthukumaraswamy, Suresh D, Saxena, Neeraj, Sumner, Rachael L, Adams, Natalie E, Moran, Rosalyn J, Singh, Krish D

“…Cortical recordings of task-induced oscillations following subanaesthetic ketamine administration demonstrate alterations in amplitude, including increases at…”
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Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex by Sumner, Rachael L, Spriggs, Meg J, Shaw, Alexander D

“…Neuroplasticity is essential to learning and memory in the brain; it has therefore also been implicated in numerous neurological and psychiatric disorders,…”
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Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex by Shaw, Alexander D, Saxena, Neeraj, E. Jackson, Laura, Hall, Judith E, Singh, Krish D, Muthukumaraswamy, Suresh D

“…Abstract At subanaesthetic doses, ketamine, an N-methyl- d -aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant efficacy…”
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A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography by Saxena, Neeraj, Muthukumaraswamy, Suresh D., Richmond, Lewys, Babic, Adele, Singh, Krish D., Hall, Judith E., Wise, Richard G., Shaw, Alexander D.

“…Studying changes in cortical oscillations can help elucidate the mechanistic link between receptor physiology and the clinical effects of anaesthetic drugs…”
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Neurophysiological evidence that frontoparietal connectivity and GABA-A receptor changes underpin the antidepressant response to ketamine by Sumner, Rachael L., McMillan, Rebecca L., Forsyth, Anna, Muthukumaraswamy, Suresh D., Shaw, Alexander D.

“…Revealing the acute cortical pharmacodynamics of an antidepressant dose of ketamine in humans with depression is key to determining the specific mechanism(s)…”
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Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans by Muthukumaraswamy, Suresh D, Shaw, Alexander D, Jackson, Laura E, Hall, Judith, Moran, Rosalyn, Saxena, Neeraj

“…Following the discovery of the antidepressant properties of ketamine, there has been a recent resurgence in the interest in this NMDA receptor antagonist…”
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Nonlinear rotordynamics of a MDOF rotor–stator contact system subjected to frictional and gravitational effects by Chipato, Elijah T, Shaw, Alexander D, Friswell, Michael I

“…•Internal resonance induced partial contacting solutions persist in MDOF systems with multiple contacts.•Friction induced asynchronous partial contacting…”
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In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies by Shaw, Alexander D, Hughes, Laura E, Moran, Rosalyn, Coyle-Gilchrist, Ian, Rittman, Tim, Rowe, James B

“…Abstract The analysis of neural circuits can provide crucial insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative…”
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Harmonic-Balance-Based parameter estimation of nonlinear structures in the presence of Multi-Harmonic response and force by Taghipour, Javad, Haddad Khodaparast, Hamed, Friswell, Michael I., Shaw, Alexander D., Jalali, Hassan, Jamia, Nidhal

“…•A nonlinear system identification method using Harmonic Balance is developed.•The proposed method is capable of accurately identifying non-smooth…”
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Continuation analysis of a nonlinear rotor system by Akay, Mehmet Selim, Shaw, Alexander D., Friswell, Michael I.

“…Nonlinearities in rotating systems have been seen to cause a wide variety of rich phenomena; however, the understanding of these phenomena has been limited…”
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GABAergic cortical network physiology in frontotemporal lobar degeneration by Adams, Natalie E, Hughes, Laura E, Rouse, Matthew A, Phillips, Holly N, Shaw, Alexander D, Murley, Alexander G, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Street, Duncan, Holland, Negin, Nesbitt, David, Friston, Karl, Rowe, James B

“…The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and…”
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Twist morphing of a composite rotor blade using a novel metamaterial by Gu, Huaiyuan, Shaw, Alexander D., Amoozgar, Mohammadreza, Zhang, Jiaying, Wang, Chen, Friswell, Michael I.

“…A novel meta-material has been designed and implemented into a rotor blade to enhance aerodynamic efficiency by achieving a passive twist during rotation. The…”
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Model updating strategy for structures with localised nonlinearities using frequency response measurements by Wang, Xing, Hill, Thomas L., Neild, Simon A., Shaw, Alexander D., Haddad Khodaparast, Hamed, Friswell, Michael I.

“…•The strategy relies on data acquired using sinusoidal excitation, an established testing procedure in the aerospace industry.•A novel semi-analytical output…”
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Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) by Egerton, Alice, Murphy, Anna, Donocik, Jacek, Anton, Adriana, Barker, Gareth J, Collier, Tracy, Deakin, Bill, Drake, Richard, Eliasson, Emma, Emsley, Richard, Gregory, Catherine J, Griffiths, Kira, Kapur, Shitij, Kassoumeri, Laura, Knight, Laura, Lambe, Emily J B, Lawrie, Stephen M, Lees, Jane, Lewis, Shôn, Lythgoe, David J, Matthews, Julian, McGuire, Philip, McNamee, Lily, Semple, Scott, Shaw, Alexander D, Singh, Krish D, Stockton-Powdrell, Charlotte, Talbot, Peter S, Veronese, Mattia, Wagner, Ernest, Walters, James T R, Williams, Stephen R, MacCabe, James H, Howes, Oliver D

“…Abstract The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent…”
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Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia by Shaw, Alexander D, Knight, Laura, Freeman, Tom C A, Williams, Gemma M, Moran, Rosalyn J, Friston, Karl J, Walters, James T R, Singh, Krish D

“…The dysconnection hypothesis of schizophrenia (SZ) proposes that psychosis is best understood in terms of aberrant connectivity. Specifically, it suggests that…”
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Localisation of local nonlinearities in structural dynamics using spatially incomplete measured data by Wang, Xing, Khodaparast, Hamed Haddad, Shaw, Alexander D., Friswell, Michael I., Zheng, Gangtie

“…•The method does not require measurements of the nonlinear elements.•The Craig-Bampton reduction method is employed to reduce the dynamic equation.•Numerical…”
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Experimental characterisation of asynchronous partially contacting motion in a multiple-degree-of-freedom rotor system by Crespo, Rafael Sánchez, Shaw, Alexander D., Friswell, Michael I., Champneys, Alan R.

“…[Display omitted] •Asynchronous bouncing motion in rotating systems with intermittent contact.•Experimental validation in a multi-degree-of-freedom rotating…”
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GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography by Adams, Natalie E, Hughes, Laura E, Phillips, Holly N, Shaw, Alexander D, Murley, Alexander G, Nesbitt, David, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Rowe, James B

“…To bridge the gap between preclinical cellular models of disease and imaging of human cognitive network dynamics, there is a pressing need for informative…”
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Explanation of the onset of bouncing cycles in isotropic rotor dynamics; a grazing bifurcation analysis by Mora, Karin, Champneys, Alan R., Shaw, Alexander D., Friswell, Michael I.

“…The dynamics associated with bouncing-type partial contact cycles are considered for a 2 degree-of-freedom unbalanced rotor in the rigid-stator limit…”
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