Search Results - "Shastry, Suresh"

A Critical Role for LTA₄H in Limiting Chronic Pulmonary Neutrophilic Inflammation by Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin

“…Leukotriene A₄ hydrolase (LTA₄H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene B₄ (LTB₄). LTA₄H also possesses…”
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A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease by Sloane, Peter A, Shastry, Suresh, Wilhelm, Andrew, Courville, Clifford, Tang, Li Ping, Backer, Kyle, Levin, Elina, Raju, S Vamsee, Li, Yao, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William, Sorscher, Eric J, Dransfield, Mark T, Rowe, Steven M

“…Mucus stasis in chronic obstructive pulmonary disease (COPD) is a significant contributor to morbidity and mortality. Potentiators of cystic fibrosis…”
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Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography by Liu, Linbo, Chu, Kengyeh K, Houser, Grace H, Diephuis, Bradford J, Li, Yao, Wilsterman, Eric J, Shastry, Suresh, Dierksen, Gregory, Birket, Susan E, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William E, Sorscher, Eric J, Rowe, Steven M, Tearney, Guillermo J

“…We demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of…”
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Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK by Shastry, Suresh, James, Leighton R

“…Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports…”
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GABA receptors and nitric oxide ameliorate constrictive collagen remodeling in hyperhomocysteinemia by Shastry, Suresh, Moning, LaQuita, Tyagi, Neetu, Steed, Mesia, Tyagi, Suresh C.

“…Elevated plasma levels of homocysteine (Hcy) are associated with vascular dementias and Alzheimer's disease. The role of Hcy in brain microvascular endothelial…”
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A Functional Anatomic Defect of the Cystic Fibrosis Airway by BIRKET, Susan E, CHU, Kengyeh K, WATSON, John D, SMITH, Alexander T, SCHUSTER, Benjamin S, HANES, Justin, GRIZZLE, William E, SORSCHER, Eric J, TEARNEY, Guillermo J, ROWE, Steven M, LINBO LIU, HOUSER, Grace H, DIEPHUIS, Bradford J, WILSTERMAN, Eric J, DIERKSEN, Gregory, MAZUR, Marina, SHASTRY, Suresh, YAO LI

“…The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. To establish mechanisms linking anion transport with the functional…”
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Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy by Birket, Susan E, Chu, Kengyeh K, Houser, Grace H, Liu, Linbo, Fernandez, Courtney M, Solomon, George M, Lin, Vivian, Shastry, Suresh, Mazur, Marina, Sloane, Peter A, Hanes, Justin, Grizzle, William E, Sorscher, Eric J, Tearney, Guillermo J, Rowe, Steven M

“…Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism…”
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The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases by Macé, Camille, Del Nogal Avila, Maria, Marshall, Caroline B, Kharlyngdoh, Joubert, Das, Ranjan, Molina-Jijon, Eduardo, Donoro Blazquez, Hector, Shastry, Suresh, Soria, Elisabeth, Wetzels, Jack, Dijkman, Henry, Avila-Casado, Carmen, Clement, Lionel C, Chugh, Sumant S

“…Zinc fingers and homeoboxes (ZHX) proteins are heterodimeric transcriptional factors largely expressed at the cell membrane in podocytes in vivo. We found…”
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An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load by Liu, Linbo, Shastry, Suresh, Byan-Parker, Suzanne, Houser, Grace, K Chu, Kengyeh, Birket, Susan E, Fernandez, Courtney M, Gardecki, Joseph A, Grizzle, William E, Wilsterman, Eric J, Sorscher, Eric J, Rowe, Steven M, Tearney, Guillermo J

“…Mucociliary clearance, characterized by mucus secretion and its conveyance by ciliary action, is a fundamental physiological process that plays an important…”
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Homocysteine induces metalloproteinase and shedding of β-1 integrin in microvessel endothelial cells by Shastry, Suresh, Tyagi, Suresh C.

“…Although studies have suggested microvessel endothelial cells (MVEC) activation and induction of matrix metalloproteinases (MMPs) by homocysteine (Hcy), the…”
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A Critical Role for LTA 4 H in Limiting Chronic Pulmonary Neutrophilic Inflammation by Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin

“…Smoke Gets in Your Lungs Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States, primarily caused by cigarette smoking…”
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A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation by SNELGROVE, Robert J, JACKSON, Patricia L, BLALOCK, J. Edwin, HARDISON, Matthew T, NOERAGER, Brett D, KINLOCH, Andrew, GAGGAR, Amit, SHASTRY, Suresh, ROWE, Steven M, SHIM, Yun M, HUSSELL, Tracy

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GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells by Shastry, Suresh, Tyagi, Neetu, Moshal, Karni S, Lominadze, David, Hayden, Melvin R, Tyagi, Suresh C

“…Mammalian endothelial cells are deficient in cystathionine beta synthetase (CBS) activity, which is responsible for homocysteine (Hcy) clearance. This…”
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Extracellular protease from Pseudomonas sp. (CL 1457) active against Xanthomonas campestris by Shastry, Suresh, Prasad, M.S

“…An extracellular cell lytic enzyme from Pseudomonas sp. (CL1457) active against heat killed cells of Xanthomonas campestris was isolated from soil samples. The…”
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Technological application of an extracellular cell lytic enzyme in xanthan gum clarification by Shastry, Suresh, Prasad, M.S.

“…An extracellular cell lytic enzyme from Pseudomonas sp. was active on heat killed cells of Xanthomonas campestris. The lytic activity caused enzymatic…”
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Matrix metalloproteinase in left ventricular remodeling and heart failure by Shastry, Suresh, Hayden, Melvin R, Lucchesi, Pamela A, Tyagi, Suresh C

“…Accumulation of oxidized matrix between the endothelium and cardiac muscle, and endocardial endothelial dysfunction, are the hallmarks of congestive heart…”
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