Search Results - "Shashaty, Michael"

Impact of Obesity in Critical Illness by Anderson, Michaela R., Shashaty, Michael G.S.

“…The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and physiological effects with significant implications for critical illness…”
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Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study by Miano, Todd A., Hennessy, Sean, Yang, Wei, Dunn, Thomas G., Weisman, Ariel R., Oniyide, Oluwatosin, Agyekum, Roseline S., Turner, Alexandra P., Ittner, Caroline A. G., Anderson, Brian J., Wilson, F. Perry, Townsend, Raymond, Reilly, John P., Giannini, Heather M., Cosgriff, Christopher V., Jones, Tiffanie K., Meyer, Nuala J., Shashaty, Michael G. S.

“…Purpose Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether…”
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Metabolic Syndrome and Acute Respiratory Distress Syndrome Outcomes: A Most Ingenious Paradox or a Devil in the Details? by Anderson, Michaela R, Shashaty, Michael G S

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Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury by Hotz, Meghan J, Qing, Danielle, Shashaty, Michael G S, Zhang, Peggy, Faust, Hilary, Sondheimer, Neal, Rivella, Stefano, Worthen, G Scott, Mangalmurti, Nilam S

“…Potentially hazardous CpG-containing cell-free mitochondrial DNA (cf-mtDNA) is routinely released into the circulation and is associated with morbidity and…”
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Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis by Reilly, John P., Wang, Fan, Jones, Tiffanie K., Palakshappa, Jessica A., Anderson, Brian J., Shashaty, Michael G. S., Dunn, Thomas G., Johansson, Erik D., Riley, Thomas R., Lim, Brian, Abbott, Jason, Ittner, Caroline A. G., Cantu, Edward, Lin, Xihong, Mikacenic, Carmen, Wurfel, Mark M., Christiani, David C., Calfee, Carolyn S., Matthay, Michael A., Christie, Jason D., Feng, Rui, Meyer, Nuala J.

“…Purpose A causal biomarker for acute respiratory distress syndrome (ARDS) could fuel precision therapy options. Plasma angiopoietin-2 (ANG2), a vascular…”
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Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States by Anesi, George L, Jablonski, Juliane, Harhay, Michael O, Atkins, Joshua H, Bajaj, Jasmeet, Baston, Cameron, Brennan, Patrick J, Candeloro, Christina L, Catalano, Lauren M, Cereda, Maurizio F, Chandler, John M, Christie, Jason D, Collins, Tara, Courtright, Katherine R, Fuchs, Barry D, Gordon, Emily, Greenwood, John C, Gudowski, Steven, Hanish, Asaf, Hanson, 3rd, C William, Heuer, Monica, Kinniry, Paul, Kornfield, Zev Noah, Kruse, Gregory B, Lane-Fall, Meghan, Martin, Niels D, Mikkelsen, Mark E, Negoianu, Dan, Pascual, Jose L, Patel, Maulik B, Pugliese, Steven C, Qasim, Zaffer A, Reilly, John P, Salmon, John, Schweickert, William D, Scott, Michael J, Shashaty, Michael G S, Sicoutris, Corinna P, Wang, John K, Wang, Wei, Wani, Arshad A, Anderson, Brian J, Gutsche, Jacob T

“…The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. To describe the epidemiology of COVID-19-related…”
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False-Positive Rate of AKI Using Consensus Creatinine-Based Criteria by Lin, Jennie, Fernandez, Hilda, Shashaty, Michael G S, Negoianu, Dan, Testani, Jeffrey M, Berns, Jeffrey S, Parikh, Chirag R, Wilson, F Perry

“…Use of small changes in serum creatinine to diagnose AKI allows for earlier detection but may increase diagnostic false-positive rates because of inherent…”
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The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness by Reilly, John P, Meyer, Nuala J, Shashaty, Michael Gs, Anderson, Brian J, Ittner, Caroline, Dunn, Thomas G, Lim, Brian, Forker, Caitlin, Bonk, Michael P, Kotloff, Ethan, Feng, Rui, Cantu, Edward, Mangalmurti, Nilam S, Calfee, Carolyn S, Matthay, Michael A, Mikacenic, Carmen, Walley, Keith R, Russell, James, Christiani, David C, Wurfel, Mark M, Lanken, Paul N, Reilly, Muredach P, Christie, Jason D

“…BACKGROUNDThe ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases, including acute respiratory…”
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Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration by Meyer, Nuala J., Reilly, John P., Anderson, Brian J., Palakshappa, Jessica A., Jones, Tiffanie K., Dunn, Thomas G., Shashaty, Michael G. S., Feng, Rui, Christie, Jason D., Opal, Steven M.

“…OBJECTIVE:Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in…”
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Volume Management with Kidney Replacement Therapy in the Critically Ill Patient by Wang, Christina H, Fay, Kevin, Shashaty, Michael G S, Negoianu, Dan

“…While the administration of intravenous fluids remains an important treatment, the negative consequences of subsequent fluid overload have raised questions…”
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A Multibiomarker-Based Outcome Risk Stratification Model for Adult Septic Shock by Wong, Hector R, Lindsell, Christopher J, Pettilä, Ville, Meyer, Nuala J, Thair, Simone A, Karlsson, Sari, Russell, James A, Fjell, Christopher D, Boyd, John H, Ruokonen, Esko, Shashaty, Michael G S, Christie, Jason D, Hart, Kimberly W, Lahni, Patrick, Walley, Keith R

“…OBJECTIVES:Clinical trials in septic shock continue to fail due, in part, to inequitable and sometimes unknown distribution of baseline mortality risk between…”
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Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis by Reilly, John P., Zhao, Zhiguo, Shashaty, Michael G. S., Koyama, Tatsuki, Jones, Tiffanie K., Anderson, Brian J., Ittner, Caroline A., Dunn, Thomas, Miano, Todd A., Oniyide, Oluwatosin, Balmes, John R., Matthay, Michael A., Calfee, Carolyn S., Christie, Jason D., Meyer, Nuala J., Ware, Lorraine B.

“…Purpose Exposures to ambient air pollutants may prime the lung enhancing risk of acute respiratory distress syndrome (ARDS) in sepsis. Our objective was to…”
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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients by Faust, Hilary E., Reilly, John P., Anderson, Brian J., Ittner, Caroline A.G., Forker, Caitlyn M., Zhang, Peggy, Weaver, Benjamin A., Holena, Daniel N., Lanken, Paul N., Christie, Jason D., Meyer, Nuala J., Mangalmurti, Nilam S., Shashaty, Michael G.S.

“…Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical…”
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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study by Anderson, Brian J, Calfee, Carolyn S, Liu, Kathleen D, Reilly, John P, Kangelaris, Kirsten N, Shashaty, Michael G S, Lazaar, Aili L, Bayliffe, Andrew I, Gallop, Robert J, Miano, Todd A, Dunn, Thomas G, Johansson, Erik, Abbott, Jason, Jauregui, Alejandra, Deiss, Thomas, Vessel, Kathryn, Belzer, Annika, Zhuo, Hanjing, Matthay, Michael A, Meyer, Nuala J, Christie, Jason D

“…Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether…”
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Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome by Jones, Tiffanie K, Feng, Rui, Kerchberger, V Eric, Reilly, John P, Anderson, Brian J, Shashaty, Michael G S, Wang, Fan, Dunn, Thomas G, Riley, Thomas R, Abbott, Jason, Ittner, Caroline A G, Christiani, David C, Mikacenic, Carmen, Wurfel, Mark M, Ware, Lorraine B, Calfee, Carolyn S, Matthay, Michael A, Christie, Jason D, Meyer, Nuala J

“…Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products)…”
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Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma by Reilly, John P, Zhao, Zhiguo, Shashaty, Michael G S, Koyama, Tatsuki, Christie, Jason D, Lanken, Paul N, Wang, Chunxue, Balmes, John R, Matthay, Michael A, Calfee, Carolyn S, Ware, Lorraine B

“…Exposure to air pollution has molecular and physiologic effects on the lung that may increase the risk of acute respiratory distress syndrome (ARDS) after…”
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Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study by Shashaty, Michael G S, Reilly, John P, Faust, Hilary E, Forker, Caitlin M, Ittner, Caroline A G, Zhang, Peggy X, Hotz, Meghan J, Fitzgerald, David, Yang, Wei, Anderson, Brian J, Holena, Daniel N, Lanken, Paul N, Christie, Jason D, Meyer, Nuala J, Mangalmurti, Nilam S

“…Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of…”
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Admission plasma levels of the neuronal injury marker neuron specific enolase are associated with mortality and delirium in sepsis by Anderson, Brian J., M.D., M.S, Reilly, John P., M.D., M.S, Shashaty, Michael G.S., M.D., M.S, Palakshappa, Jessica A., M.D, Wysoczanski, Alex, Dunn, Thomas G., B.A, Kazi, Altaf, Ph.D, Tommasini, Anna, B.A, Mikkelsen, Mark E., M.D., M.S, Schweickert, William D., M.D, Kolson, Dennis L., M.D., Ph.D, Christie, Jason D., M.D., M.S, Meyer, Nuala J., M.D., M.S

“…Abstract Purpose Neuron specific enolase (NSE) concentrations are prognostic following traumatic and anoxic brain injury, and may provide a method to quantify…”
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Physiological and management implications of obesity in critical illness by Shashaty, Michael G S, Stapleton, Renee D

“…Obesity is highly prevalent in the United States and is becoming increasingly common worldwide. The anatomic and physiological changes that occur in obese…”
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African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients by Shashaty, Michael G.S., MD, MSCE, Meyer, Nuala J., MD, MS, Localio, A. Russell, PhD, Gallop, Robert, PhD, Bellamy, Scarlett L., ScD, Holena, Daniel N., MD, Lanken, Paul N., MD, Kaplan, Sandra, BSN, Yarar, Dilek, MD, Kawut, Steven M., MD, MSCE, Feldman, Harold I., MD, MSCE, Christie, Jason D., MD, MSCE

“…Abstract Purpose Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney…”
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