Search Results - "Shashank, M."

Facile microwave-assisted green synthesis of NiO nanoparticles from Andrographis paniculata leaf extract and evaluation of their photocatalytic and anticancer activities by Karthik, K., Shashank, M., Revathi, V., Tatarchuk, Tetiana

“…In the present work, NiO nanoparticles based on Andrographis paniculata (leaf extract) were prepared through the microwave-assisted method. The obtained…”
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Integrated network pharmacology and molecular modeling approach for the discovery of novel potential MAPK3 inhibitors from whole green jackfruit flour targeting obesity-linked diabetes mellitus by Maradesha, Tejaswini, Martiz, Reshma Mary, Patil, Shashank M, Prasad, Ashwini, Babakr, Abdullatif Taha, Silina, Ekaterina, Stupin, Victor, Achar, Raghu Ram, Ramu, Ramith

“…The current study investigates the effectiveness of phytocompounds from the whole green jackfruit flour methanol extract (JME) against obesity-linked diabetes…”
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Azadirachta indica A. Juss (neem) against diabetes mellitus: a critical review on its phytochemistry, pharmacology, and toxicology by Patil, Shashank M, Shirahatti, Prithvi S, Ramu, Ramith

“…Abstract Objective We aim to provide a critical review focused on the various pharmacological activities of Azadirachta indica A. Juss related to diabetes…”
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Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning by Yadav, Roopali, Hillman, Brandon G, Gupta, Subhash C, Suryavanshi, Pratyush, Bhatt, Jay M, Pavuluri, Ratnamala, Stairs, Dustin J, Dravid, Shashank M

“…Glutamate delta-1 (GluD1) receptors are expressed throughout the forebrain during development with high levels in the hippocampus during adulthood. We have…”
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CD4+ T cell help during early acute hepacivirus infection is critical for viral clearance and the generation of a liver-homing CD103+CD49a+ effector CD8+ T cell subset by Lopez-Scarim, Jarrett, Mendoza, Dustyn, Nambiar, Shashank M, Billerbeck, Eva

“…In hepatitis C virus (HCV) infection, CD4+ and CD8+ T cells are crucial for viral control. However, a detailed understanding of the kinetic of CD4+ T cell help…”
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Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations by Maradesha, Tejaswini, Patil, Shashank M, Al-Mutairi, Khalid Awadh, Ramu, Ramith, Madhunapantula, SubbaRao V, Alqadi, Taha

“…For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple stages inhibitory assays were used to explore the antidiabetic…”
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Computer-Aided Screening of Phytoconstituents from Ocimum tenuiflorum against Diabetes Mellitus Targeting DPP4 Inhibition: A Combination of Molecular Docking, Molecular Dynamics, and Pharmacokinetics Approaches by Sajal, Harshit, Patil, Shashank M., Raj, Ranjith, Shbeer, Abdullah M., Ageel, Mohammed, Ramu, Ramith

“…Diabetes mellitus is a major global health concern in the current scenario which is chiefly characterized by the rise in blood sugar levels or hyperglycemia…”
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Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model by Ravikrishnan, Aparna, Gandhi, Pauravi J., Shelkar, Gajanan P., Liu, Jinxu, Pavuluri, Ratnamala, Dravid, Shashank M.

“…[Display omitted] •GluN2C is expressed in parvalbumin-positive neurons in a subset of basal ganglia nuclei.•GluN2C is localized to astrocytes in majority of…”
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Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods by Martiz, Reshma Mary, Patil, Shashank M, Abdulaziz, Mohammed, Babalghith, Ahmed, Al-Areefi, Mahmoud, Al-Ghorbani, Mohammed, Mallappa Kumar, Jayanthi, Prasad, Ashwini, Mysore Nagalingaswamy, Nagendra Prasad, Ramu, Ramith

“…The present study involves the integrated network pharmacology and phytoinformatics-based investigation of phytocompounds from against diabetes mellitus-linked…”
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A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn by Patil, Shashank M., Ramu, Ramith, Shirahatti, Prithvi S., Shivamallu, Chandan, Amachawadi, Raghavendra G.

“…Thymus vulgaris Linn. is a medicinal and culinary herb from the Southern European region known for its anti-infective, cardioprotective, gastroprotective,…”
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Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches by Patil, Shashank M, Martiz, Reshma Mary, Satish, A M, Shbeer, Abdullah M, Ageel, Mohammed, Al-Ghorbani, Mohammed, Ranganatha, 5th, Lakshmi, Parameswaran, Saravanan, Ramu, Ramith

“…Coumarin derivatives are proven for their therapeutic uses in several human diseases and disorders such as inflammation, neurodegenerative disorders, cancer,…”
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Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach by Martiz, Reshma Mary, Patil, Shashank M, Ramu, Ramith, M K, Jayanthi, P, Ashwini, Ranganatha, Lakshmi V, Khanum, Shaukath Ara, Silina, Ekaterina, Stupin, Victor, Achar, Raghu Ram

“…The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid hypothesis caused due to formation of accumulation of Aβ42 isoform, which…”
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A mouse model of seizures in anti–N‐methyl‐d‐aspartate receptor encephalitis by Taraschenko, Olga, Fox, Howard S., Pittock, Sean J., Zekeridou, Anastasia, Gafurova, Maftuna, Eldridge, Ember, Liu, Jinxu, Dravid, Shashank M., Dingledine, Raymond

“…Summary Objective Seizures develop in 80% of patients with anti–N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis, and these represent a major cause of…”
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An emerging map of glutamate delta 1 receptors in the forebrain by Andrews, Patrick C., Dravid, Shashank M.

“…Glutamate delta 1 (GluD1) and glutamate delta 2 (GluD2) form the delta family of ionotropic glutamate receptors; these proteins plays widespread roles in…”
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Essential Roles for ARID1B in Dendritic Arborization and Spine Morphology of Developing Pyramidal Neurons by Ka, Minhan, Chopra, Divyan A, Dravid, Shashank M, Kim, Woo-Yang

“…De novo truncating mutations in ARID1B, a chromatin-remodeling gene, cause Coffin-Siris syndrome, a developmental disorder characterized by intellectual…”
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Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction by Shelkar, Gajanan P, Liu, Jinxu, Dravid, Shashank M

“…Abstract Background Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-site agonist D-cycloserine is known to facilitate fear…”
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Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors by Yadav, Roopali, Gupta, Subhash C, Hillman, Brandon G, Bhatt, Jay M, Stairs, Dustin J, Dravid, Shashank M

“…The delta family of ionotropic glutamate receptors consists of glutamate δ1 (GluD1) and glutamate δ2 (GluD2) receptors. While the role of GluD2 in the…”
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Computational approaches to define poncirin from Magnolia champaka leaves as a novel multi-target inhibitor of SARS-CoV-2 by Patil, Shashank M., Phanindra, Bhaskar, Shirahatti, Prithvi S., Martiz, Reshma Mary, Sajal, Harshit, Babakr, Abdullatif Taha, Ramu, Ramith

“…Phytochemical-based drug discovery against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been the focus of the current scenario. In this…”
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Phyto-Computational Intervention of Diabetes Mellitus at Multiple Stages Using Isoeugenol from Ocimum tenuiflorum: A Combination of Pharmacokinetics and Molecular Modelling Approaches by Martiz, Reshma Mary, Patil, Shashank M., Thirumalapura Hombegowda, Deepika, Shbeer, Abdullah M., Alqadi, Taha, Al-Ghorbani, Mohammed, Ramu, Ramith, Prasad, Ashwini

“…In the present study, the anti-diabetic potential of Ocimum tenuiflorum was investigated using computational techniques for α-glucosidase, α-amylase, aldose…”
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Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions by Gakare, Sukanya G, Bhatt, Jay M, Narasimhan, Kishore Kumar S, Dravid, Shashank M

“…In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in oligodendrocyte progenitor cell (OPC)-mediated myelination during basal…”
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