Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry

Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective...

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Bibliographic Details
Published in:	Diseases of the esophagus Vol. 32; no. 9
Main Authors:	Smith, M S, Cash, B, Konda, V, Trindade, A J, Gordon, S, DeMeester, S, Joshi, V, Diehl, D, Ganguly, E, Mashimo, H, Singh, S, Jobe, B, McKinley, M, Wallace, M, Komatsu, Y, Thakkar, S, Schnoll-Sussman, F, Sharaiha, R, Kahaleh, M, Tarnasky, P, Wolfsen, H, Hawes, R, Lipham, J, Khara, H, Pleskow, D, Navaneethan, U, Kedia, P, Hasan, M, Sethi, A, Samarasena, J, Siddiqui, U D, Gress, F, Rodriguez, R, Lee, C, Gonda, T, Waxman, I, Hyder, S, Poneros, J, Sharzehi, K, Di Palma, J A, Sejpal, D V, Oh, D, Hagen, J, Rothstein, R, Sawhney, M, Berzin, T, Malik, Z, Chang, K
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 13-11-2019
Subjects:	Adult Aged Aged, 80 and over Barrett Esophagus - diagnostic imaging Barrett Esophagus - pathology Barrett Esophagus - therapy Biopsy Clinical Decision-Making Computer Systems Female Humans Male Middle Aged Original Practice Patterns, Physicians' - statistics & numerical data Prospective Studies Registries Tomography, Optical Coherence - methods Tomography, Optical Coherence - statistics & numerical data United States United States dysplasia endomicroscopy imaging Barrett's esophagus
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Summary:	Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All procedures utilized the NvisionVLE Imaging System (NinePoint Medical, Bedford, MA) which was used by investigators to identify the tissue types present, along with focal areas of concern. Following the VLE procedure, investigators were asked to answer six key questions regarding how VLE impacted each case. Statistical analyses including neoplasia diagnostic yield improvement using VLE was performed. One thousand patients were enrolled across 18 US trial sites from August 2014 through April 2016. In patients with previously diagnosed or suspected BE (894/1000), investigators used VLE and identified areas of concern not seen on white light endoscopy (WLE) in 59% of the procedures. VLE imaging also guided tissue acquisition and treatment in 71% and 54% of procedures, respectively. VLE as an adjunct modality improved the neoplasia diagnostic yield by 55% beyond the standard of care practice. In patients with no prior history of therapy, and without visual findings from other technologies, VLE-guided tissue acquisition increased neoplasia detection over random biopsies by 700%. Registry investigators reported that VLE improved the BE management process when used as an adjunct tissue acquisition and treatment guidance tool. The ability of VLE to image large segments of the esophagus with microscopic cross-sectional detail may provide additional benefits including higher yield biopsies and more efficient tissue acquisition. Clinicaltrials.gov NCT02215291.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1120-8694 1442-2050
DOI:	10.1093/dote/doz029