Search Results - "Sharrow, SO"

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells by Yu, Qing, Erman, Batu, Bhandoola, Avinash, Sharrow, Susan O, Singer, Alfred

“…CD4(+)8(+) double positive (DP) thymocytes differentiate into CD4(+) and CD8(+) mature T cells in response to TCR signals. However, TCR signals that are…”
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Monoclonal antibodies against human T cell adhesion molecules--modulation of immune function in nonhuman primates by Berlin, P J, Bacher, J D, Sharrow, S O, Gonzalez, C, Gress, R E

“…The cytotoxic T cell is thought to be a primary effector of allograft rejection. In vitro studies have demonstrated that the interaction between cytotoxic T…”
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Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells by Brugnera, Enrico, Bhandoola, Avinash, Cibotti, Ricardo, Yu, Qing, Guinter, Terry I, Yamashita, Yoshio, Sharrow, Susan O, Singer, Alfred

“…A central paradigm of T cell development is that CD4+8+ (DP) thymocytes differentiate into CD4+ or CD8+ T cells in response to intrathymic signals that…”
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Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function by Chu, Yu-Waye, Memon, Sarfraz A., Sharrow, Susan O., Hakim, Frances T., Eckhaus, Michael, Lucas, Philip J., Gress, Ronald E.

“…Interleukin 7 (IL-7) is critical in maintaining thymic-dependent and thymic-independent pathways of T-cell homeostasis. T-cell receptor (TCR) rearrangement…”
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Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing by Mackall, CL, Bare, CV, Granger, LA, Sharrow, SO, Titus, JA, Gress, RE

“…Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood…”
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A dose effect of IL-7 on thymocyte development by El Kassar, Nahed, Lucas, Philip J., Klug, David B., Zamisch, Monica, Merchant, Melinda, Bare, Catherine V., Choudhury, Baishakhi, Sharrow, Susan O., Richie, Ellen, Mackall, Crystal L., Gress, Ronald E.

“…To study interleukin-7 (IL-7) in early thymocyte development, we generated mice transgenic (Tg) for the IL-7 gene under control of thelckproximal promoter…”
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Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity by Sarafova, Sophia D., Erman, Batu, Yu, Qing, Van Laethem, François, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Wildt, Kathryn F., Ellmeier, Wilfried, Singer, Alfred

“…For developing T cells, coreceptor choice is matched to T cell antigen receptor (TCR) MHC specificity during positive selection in the thymus, but the…”
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Strength of Signaling by CD4 and CD8 Coreceptor Tails Determines the Number but Not the Lineage Direction of Positively Selected Thymocytes by Bosselut, Rémy, Feigenbaum, Lionel, Sharrow, Susan O., Singer, Alfred

“…The present study has assessed the impact of the intracellular domains of CD4 and CD8 on positive selection and lineage direction of MHC class I–restricted…”
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Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 by PUNT, J. A, OSBORNE, B. A, TAKAHAMA, Y, SHARROW, S. O, SINGER, A

“…CD4+CD8+ thymocytes expressing self-reactive T cell antigen receptors (TCR) are deleted in the thymus as a consequence of TCR/self-antigen/major…”
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Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals by Cibotti, Ricardo, Punt, Jennifer A, Dash, Krishna S, Sharrow, Susan O, Singer, Alfred

“…Differentiation of immature double positive (DP) CD4 + CD8 + thymocytes into single positive (SP) CD4 + and CD8 + T cells is referred to as positive selection…”
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Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I-signaled Thymocytes "Paradoxically" Appear as CD4 super(+)8 super(lo) Transitional Cells During Positive Selection of CD8 super(+) T Cells by Bosselut, R, Guinter, TI, Sharrow, SO, Singer, A

“…The mechanism by which T cell receptor specificity determines the outcome of the CD4/CD8 lineage decision in the thymus is not known. An important clue is the…”
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In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8 super(+) T Cells by Yu, Q, Erman, B, Bhandoola, A, Sharrow, SO, Singer, A

“…CD4 super(+)8 super(+) double positive (DP) thymocytes differentiate into CD4 super(+) and CD8 super(+) mature T cells in response to TCR signals. However, TCR…”
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CD40 Ligand Functions Non-Cell Autonomously to Promote Deletion of Self-Reactive Thymocytes by Williams, Joy A, Sharrow, Susan O, Adams, Anthony J, Hodes, Richard J

“…CD40 ligand (CD40L)-deficient mice have been shown to have a defect in negative selection of self-reactive T cells during thymic development. However, the…”
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Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production by Sanders, ME, Makgoba, MW, Sharrow, SO, Stephany, D, Springer, TA, Young, HA, Shaw, S

“…Studies of cell-surface molecules involved in human T cell interaction reveal that differential expression of each of three adhesion molecules (LFA-3, CD2, and…”
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Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection by Kearse, K P, Takahama, Y, Punt, J A, Sharrow, S O, Singer, A

“…Differentiation of immature CD4+ CD8+ thymocytes into mature CD4+ or CD8+ T cells occurs within the thymus and is dependent upon expression of antigen receptor…”
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Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities by Roberts, J L, Sharrow, S O, Singer, A

“…The present study demonstrates that immune tolerance can be achieved in the thymus both by clonal deletion and by clonal inactivation, but that the two…”
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Characterization of murine thymocytes with CD3-associated T-cell receptor structures by BLUESTONE, J. A, PARDOLL, D, SHARROW, S. O, FOWLKES, B. J

“…The thymus is the major site for T-cell receptor (TCR) gene rearrangement and T-cell maturation. The specific antigen recognition structure (TCR) on murine T…”
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Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment by Bhandoola, A, Cibotti, R, Punt, J A, Granger, L, Adams, A J, Sharrow, S O, Singer, A

“…During positive selection, immature thymocytes commit to either the CD4+ or CD8+ T cell lineage ("commitment") and convert from short-lived thymocytes into…”
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CD8 Coreceptor Extinction in Signaled CD4 super(+)CD8 super(+) Thymocytes: Coordinate Roles for Both Transcriptional and Posttranscriptional Regulatory Mechanisms in Developing Thymocytes by Cibotti, R, Bhandoola, A, Guinter, TI, Sharrow, SO, Singer, A

“…T-cell development in the thymus is characterized by changing expression patterns of CD4 and CD8 coreceptor molecules and by changes in CD4 and CD8 gene…”
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Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly- 6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR- alpha beta+ thymocytes by Takahama, Y, Sharrow, SO, Singer, A

“…A novel thymocyte subpopulation expressing an unusual TCR repertoire was identified by high surface expression of the Ly-6C Ag. Ly-6C+ thymocytes were…”
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