Search Results - "Sharratt, Peter J"

Phenylalanine meta‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation by Grüschow, Sabine, Sadler, Joanna C., Sharratt, Peter J., Goss, Rebecca J. M.

“…The rare nonproteinogenic amino acid, meta‐l‐tyrosine is biosynthetically intriguing. Whilst the biogenesis of tyrosine from phenylalanine is well…”
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The Squalestatins:  Decarboxy and 4-Deoxy Analogues as Potent Squalene Synthase Inhibitors by Chan, Chuen, Andreotti, Daniele, Cox, Brian, Dymock, Brian W, Hutson, Julie L, Keeling, Suzanne E, McCarthy, Alun D, Procopiou, Panayiotis A, Ross, Barry C, Sareen, Meenu, Scicinski, Jan J, Sharratt, Peter J, Snowden, Michael A, Watson, Nigel S

“…Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prepared and evaluated for their ability to inhibit rat liver…”
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The Squalestatins:  Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues by Procopiou, Panayiotis A, Cox, Brian, Kirk, Barrie E, Lester, Michael G, McCarthy, Alun D, Sareen, Meenu, Sharratt, Peter J, Snowden, Michael A, Spooner, Stephen J, Watson, Nigel S, Widdowson, Julia

“…Squalestatin analogues modified at C3 were prepared and evaluated for their ability to inhibit rat liver microsomal squalene synthase in vitro. While the…”
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Synthesis and structure-activity relationships in a series of antiinflammatory corticosteroid analogues, halomethyl androstane-17 beta-carbothioates and -17 beta-carboselenoates by Phillipps, G H, Bailey, E J, Bain, B M, Borella, R A, Buckton, J B, Clark, J C, Doherty, A E, English, A F, Fazakerley, H, Laing, S B

“…The preparation and topical antiinflammatory potencies of a series of halomethyl 17 alpha-(acyloxy)- 11 beta-hydroxy-3-oxoandrosta-1,4-diene-17…”
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The squalestatins: tricyclic 3,4-β-lactone and 3,4-oxetane systems by Cox, Brian, Morley, Nicolas, Procopiou, Panayiotis A, Sharratt, Peter J, Watson, Nigel S, Wild, Deborah

“…Squalestatin 3,4-β-lactone-4,5-dimethyl ester ( 8) was reductively ring-opened to yield squalestatin 3-hydroxymethyl-4,5-dimethyl ester ( 6) using mild…”
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The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs by Procopiou, Panayiotis A, Bailey, Esme J, Bamford, Mark J, Craven, Andy P, Dymock, Brian W, Houston, John G, Hutson, Julie L, Kirk, Barrie E, McCarthy, Alun D

“…Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene…”
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