Search Results - "Sharpless, K. Barry"

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry by Dong, Jiajia, Krasnova, Larissa, Finn, M. G., Sharpless, K. Barry

“…Aryl sulfonyl chlorides (e.g. Ts‐Cl) are beloved of organic chemists as the most commonly used SVI electrophiles, and the parent sulfuryl chloride, O2SVICl2,…”
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SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization by Liu, Zilei, Li, Jie, Li, Suhua, Li, Gencheng, Sharpless, K. Barry, Wu, Peng

“…Sulfur­(VI) Fluoride Exchange (SuFEx) is a new family of click chemistry transformations which relies on readily available materials to produce compounds…”
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase by Zheng, Qinheng, Woehl, Jordan L., Kitamura, Seiya, Santos-Martins, Diogo, Smedley, Christopher J., Li, Gencheng, Forli, Stefano, Moses, John E., Wolan, Dennis W., Sharpless, K. Barry

“…Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and…”
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A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope by Guo, Taijie, Meng, Genyi, Zhan, Xiongjie, Yang, Qian, Ma, Tiancheng, Xu, Long, Sharpless, K. Barry, Dong, Jiajia

“…Sulfuryl fluoride, SO2F2, has been found to derivatize phenols in all kinds of environments, even those in highly functional molecules. We now report that a…”
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SuFExable polymers with helical structures derived from thionyl tetrafluoride by Li, Suhua, Li, Gencheng, Gao, Bing, Pujari, Sidharam P., Chen, Xiaoyan, Kim, Hyunseok, Zhou, Feng, Klivansky, Liana M., Liu, Yi, Driss, Hafedh, Liang, Dong-Dong, Lu, Jianmei, Wu, Peng, Zuilhof, Han, Moses, John, Sharpless, K. Barry

“…Sulfur( vi ) fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulfur( vi ) connective hubs…”
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Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery by Brighty, Gabriel J., Botham, Rachel C., Li, Suhua, Nelson, Luke, Mortenson, David E., Li, Gencheng, Morisseau, Christophe, Wang, Hua, Hammock, Bruce D., Sharpless, K. Barry, Kelly, Jeffery W.

“…Drug candidates that form covalent linkages with their target proteins have been underexplored compared with the conventional counterparts that modulate…”
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Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins by Liu, Feng, Wang, Hua, Li, Suhua, Bare, Grant A. L., Chen, Xuemin, Wang, Chu, Moses, John E., Wu, Peng, Sharpless, K. Barry

“…We report here the development of a suite of biocompatible SuFEx transformations from the SOF4‐derived iminosulfur oxydifluoride hub in aqueous buffer…”
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SuFEx‐Based Polysulfonate Formation from Ethenesulfonyl Fluoride–Amine Adducts by Wang, Hua, Zhou, Feng, Ren, Gerui, Zheng, Qinheng, Chen, Hongli, Gao, Bing, Klivansky, Liana, Liu, Yi, Wu, Bin, Xu, Qingfeng, Lu, Jianmei, Sharpless, K. Barry, Wu, Peng

“…The SuFEx‐based polycondensation between bisalkylsulfonyl fluorides (AA monomers) and bisphenol bis(t‐butyldimethylsilyl) ethers (BB monomers) using…”
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Copper(I)‐Catalyzed Cycloaddition of Organic Azides and 1‐Iodoalkynes by Hein, Jason E., Tripp, Jonathan C., Krasnova, Larissa B., Sharpless, K. Barry, Fokin, Valery V.

“…High fidelity: 1‐Iodoalkynes react rapidly and selectively with organic azides in the presence of copper(I) catalysts (see scheme;…”
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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs by Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.

“…Diversity Oriented Clicking (DOC) is a unified click‐approach for the modular synthesis of lead‐like structures through application of the wide family of click…”
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Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification by Hong, Senlian, Shi, Yujie, Wu, Nicholas C., Grande, Geramie, Douthit, Lacey, Wang, Hua, Zhou, Wen, Sharpless, K. Barry, Wilson, Ian A., Xie, Jia, Wu, Peng

“…Chemoenzymatic modification of cell-surface glycan structures has emerged as a complementary approach to metabolic oligosaccharide engineering. Here, we…”
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Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure by Sit, Rakesh K, Kovarik, Zrinka, Maček Hrvat, Nikolina, Žunec, Suzana, Green, Carol, Fokin, Valery V, Sharpless, K Barry, Radić, Zoran, Taylor, Palmer

“…In the development of antidotal therapy for treatment of organophosphate exposure from pesticides used in agriculture and nerve agents insidiously employed in…”
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SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues by Carter, Trever R., Milosevich, Natalia, Dada, Lucas, Shaum, James B., Barry Sharpless, K., Kitamura, Seiya, Erb, Michael A.

“…[Display omitted] Molecular glues are small molecules that stabilize protein–protein interactions, enabling new molecular pharmacologies, such as targeted…”
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Copper-Catalyzed Synthesis of N-Sulfonyl-1,2,3-triazoles: Controlling Selectivity by Yoo, Eun Jeong, Ahlquist, Mårten, Kim, Seok Hwan, Bae, Imhyuck, Fokin, Valery V., Sharpless, K. Barry, Chang, Sukbok

“…4‐Substituted 1‐(N‐sulfonyl)‐1,2,3‐triazoles are selectively obtained by using the Cu‐catalyzed azide–alkyne cycloaddition reaction with sulfonyl azides…”
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Efficient Synthesis of 2-Substituted-1,2,3-triazoles by Kalisiak, Jarosław, Sharpless, K. Barry, Fokin, Valery V

“…In this three-component reaction, alkynes undergo a copper(I)-catalyzed cycloaddition with sodium azide and formaldehyde to yield…”
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Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates by Himo, Fahmi, Lovell, Timothy, Hilgraf, Robert, Rostovtsev, Vsevolod V, Noodleman, Louis, Sharpless, K. Barry, Fokin, Valery V

“…Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react with azides and nitrile oxides, providing ready access to…”
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Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms by Gahtory, Digvijay, Sen, Rickdeb, Pujari, Sidharam, Li, Suhua, Zheng, Qinheng, Moses, John E., Sharpless, K. Barry, Zuilhof, Han

“…The constraints of minute reactant amounts and the impossibility to remove any undesired surface‐bound products during monolayer functionalization of a surface…”
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A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans by Baranczak, Aleksandra, Liu, Yu, Connelly, Stephen, Du, Wen-Ge Han, Greiner, Erin R, Genereux, Joseph C, Wiseman, R. Luke, Eisele, Yvonne S, Bradbury, Nadine C, Dong, Jiajia, Noodleman, Louis, Sharpless, K. Barry, Wilson, Ian A, Encalada, Sandra E, Kelly, Jeffery W

“…Fluorogenic probes, due to their often greater spatial and temporal sensitivity in comparison to permanently fluorescent small molecules, represent powerful…”
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A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes by Rostovtsev, Vsevolod V., Green, Luke G., Fokin, Valery V., Sharpless, K. Barry

“…By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4‐disubstituted 1,2,3‐triazoles through a highly…”
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Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides by Zhang, Li, Chen, Xinguo, Xue, Peng, Sun, Herman H. Y, Williams, Ian D, Sharpless, K. Barry, Fokin, Valery V, Jia, Guochen

“…Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective “fusion” of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles…”
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