Search Results - "Sharpe, M. A."

β‐Amyloid inhibits integrated mitochondrial respiration 
and key enzyme activities by Casley, C. S., Canevari, L., Land, J. M., Clark, J. B., Sharpe, M. A.

“…Disrupted energy metabolism, in particular reduced activity of cytochrome oxidase (EC 1.9.3.1), α‐ketoglutarate dehydrogenase (EC 1.2.4.2) and pyruvate…”
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β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons by Casley, C.S., Land, J.M., Sharpe, M.A., Clark, J.B., Duchen, M.R., Canevari, L.

“…β-Amyloid deposition and compromised energy metabolism both occur in vulnerable brain regions in Alzheimer's disease. It is not known whether β-amyloid is the…”
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Laboratory rearing of Cotesia urabae Austin and Allen (Hymenoptera: Braconidae), a biological control agent of Uraba lugens Walker (Lepidoptera: Nolidae) by Berndt, L. A, Sharpe, A. M, Gresham, B. A, Hayes, D, Allen, G. R

“…Cotesia urabae (Hymenoptera: Braconidae) was released in New Zealand in 2011 for the biological control of the Eucalyptus pest Uraba lugens (Lepidoptera:…”
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Toxicity of myoglobin and haemoglobin: oxidative stress in patients with rhabdomyolysis and subarachnoid haemorrhage by Reeder, B J, Sharpe, M A, Kay, A D, Kerr, M, Moore, K, Wilson, M T

“…Haemolytic events, such as those following rhabdomyolysis and subarachnoid haemorrhage, often result in pathological complications such as vasoconstriction…”
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Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth by Tsouko, E, Khan, A S, White, M A, Han, J J, Shi, Y, Merchant, F A, Sharpe, M A, Xin, L, Frigo, D E

“…Cancer cells display an increased demand for glucose. Therefore, identifying the specific aspects of glucose metabolism that are involved in the pathogenesis…”
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Astrocyte‐Derived Nitric Oxide Causes Both Reversible and Irreversible Damage to the Neuronal Mitochondrial Respiratory Chain by Stewart, Victoria C, Sharpe, Martyn A, Clark, John B, Heales, Simon J R

“…Cytokine‐stimulated astrocytes produce nitric oxide (NO), which, along with its metabolite peroxynitrite (ONOO‐), can inhibit components of the mitochondrial…”
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Serum and urine nitrate and nitrite are not reliable indicators of intrathecal nitric oxide production in acute brain injury by Rejdak, K, Petzold, A, Sharpe, M.A, Smith, M, Keir, G, Stelmasiak, Z, Thompson, E.J, Giovannoni, G

“…This study examined the correlation between nitric oxide (NO) metabolites in the three major body fluid compartments and assessed performance of newly…”
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The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study by Svistunenko, D A, Sharpe, M A, Nicholls, P, Blenkinsop, C, Davies, N A, Dunne, J, Wilson, M T, Cooper, C E

“…The paramagnetic species in human metHb and horse metmyoglobin (metMb) have been studied at low temperature using EPR spectroscopy. The high-spin (HS) haem…”
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Efficient heuristic algorithms for maximum utility product pricing problems by Myklebust, T.G.J., Sharpe, M.A., Tunçel, L.

“…We propose improvements to some of the best heuristic algorithms for optimal product pricing problem originally designed by Dobson and Kalish in the late 1980s…”
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Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite by Sharpe, M A, Cooper, C E

“…The aerobic reactions of nitric oxide with cytochrome c were analysed. Nitric oxide (NO) reacts with ferrocytochrome c at a rate of 200 M-1 s-1 to form…”
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Transport of K+ and other cations across phospholipid membranes by nonesterified fatty acids by SHARPE, M. A, COOPER, C. E, WRIGGLESWORTH, J. M

“…The rate of change of internal pH and transmembrane potential has been monitored in liposomes following the external addition of various cation salts. Oleic…”
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Interaction of peroxynitrite with mitochondrial cytochrome oxidase. Catalytic production of nitric oxide and irreversible inhibition of enzyme activity by Sharpe, M A, Cooper, C E

“…Purified mitochondrial cytochrome c oxidase catalyzes the conversion of peroxynitrite to nitric oxide (NO). This reaction is cyanide-sensitive, indicating that…”
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Interactions of cytochrome c oxidase with nitric oxide: reactions of the 'turnover' intermediates by Wilson, M T, Torres, J, Cooper, C E, Sharpe, M A

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Characteristics and Mechanism of Formation of Peroxide-Induced Heme to Protein Cross-Linking in Myoglobin by Reeder, Brandon J, Svistunenko, Dimitri A, Sharpe, Martyn A, Wilson, Michael T

“…At acidic pH values heme−protein cross-linked myoglobin (Mb−H) forms as a product of a peroxide-induced ferric−ferryl redox cycle. There is evidence that this…”
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Cytochrome c oxidase rapidly metabolises nitric oxide to nitrite by Torres, Jaume, Sharpe, Martyn A, Rosquist, Aasa, Cooper, Chris E, Wilson, Mike T

“…Previous studies have shown that the addition of nitric oxide to cytochrome c oxidase rapidly generates spectral changes compatible with the formation of…”
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Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide? by Cooper, Chris E., Torres, Jaume, Sharpe, Martyn A., Wilson, Michael T.

“…Small increases in NO concentration can inhibit mitochondrial oxygen consumption by reacting at the binuclear haem a 3/Cu B oxygen reduction site of cytochrome…”
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The proteoliposomal steady state. Effect of size, capacitance and membrane permeability on cytochrome-oxidase-induced ion gradients by Wrigglesworth, J M, Cooper, C E, Sharpe, M A, Nicholls, P

“…1. The flux pathways for H+ and K+ movements into and out of proteoliposomes incorporating cytochrome c oxidase have been investigated as a function of the…”
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Regulation of electron flux through cytochrome c oxidase: pH, delta pH and fatty acids by Wrigglesworth, J M, Sharpe, M A, Cooper, C E

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The effect of membrane potential on the protonophoric action of oleic acid by Sharpe, M A, Cooper, C E, Wrigglesworth, J M

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Isolation of a Kell-reactive protein from red cell membranes by Wallas, C, Simon, R, Sharpe, M A, Byler, C

“…A red cell membrane protein which exhibits Kell blood group antigen activity has been identified with a purified anti-Kell bound to a Protein-A agarose column…”
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