Search Results - "Sharpe, J."

Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients by Raspopovic, J., Marcon, L., Russo, L., Sharpe, J.

“…During limb development, digits emerge from the undifferentiated mesenchymal tissue that constitutes the limb bud. It has been proposed that this process is…”
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The Epidemiology and Geographic Patterns of Natural Disaster and Extreme Weather Mortality by Race and Ethnicity, United States, 1999-2018 by Sharpe, J. Danielle, Wolkin, Amy F.

“…Objectives The adverse effects that racial and ethnic minority groups experience before, during, and after disaster events are of public health concern. The…”
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Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR) by Sharpe, Laura J., Brown, Andrew J.

“…3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the target of the statins, important drugs that lower blood cholesterol levels and treat cardiovascular…”
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Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission by Kamerkar, Sukrut C., Kraus, Felix, Sharpe, Alice J., Pucadyil, Thomas J., Ryan, Michael T.

“…Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts…”
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Traveling surface acoustic wave (TSAW) microfluidic fluorescence activated cell sorter (μFACS) by Mutafopulos, K, Spink, P, Lofstrom, C D, Lu, P J, Lu, H, Sharpe, J C, Franke, T, Weitz, D A

“…We report a microfluidic fluorescence activated cell-sorting (μFACS) device that employs traveling surface acoustic waves (TSAW) to sort cells at rates…”
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Oxysterols: From physiological tuners to pharmacological opportunities by Brown, Andrew J., Sharpe, Laura J., Rogers, Michael J.

“…Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals and ROS, or formed enzymically by a variety of enzymes such as…”
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Cardiac Pacemaker Activity and Aging by Peters, Colin H, Sharpe, Emily J, Proenza, Catherine

“…A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in humans and other mammals. This decrease in mHR is independent of gender,…”
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Modulation of Attention and Action in the Medial Prefrontal Cortex of Rats by Sharpe, Melissa J, Killcross, Simon

“…Theories of functioning in the medial prefrontal cortex are distinct across appetitively and aversively motivated procedures. In the appetitive domain, it is…”
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A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties by Sharpe, Hayley J., Stevens, Tim J., Munro, Sean

“…The various membranes of eukaryotic cells differ in composition, but it is at present unclear if this results in differences in physical properties. The…”
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A Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline by Sharpe, Robert J, Johnson, Jeffrey S

“…A stereocontrolled total synthesis of the indole diterpenoid natural product paspaline is described. Key steps include a highly diastereoselective enzymatic…”
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Differences in PrEP Awareness, Discussions with Healthcare Providers, and Use Among Men Who Have Sex with Men in the United States by Urbanicity and Region: A Cross-sectional Analysis by Rossiter, Shannon, Sharpe, J. Danielle, Pampati, Sanjana, Sanchez, Travis, Zlotorzynska, Maria, Jones, Jeb

“…Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention intervention and is critical to the Ending the HIV Epidemic strategy. Most PrEP research…”
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Unexpected consequences: exon skipping caused by CRISPR-generated mutations by Sharpe, Joshua J, Cooper, Thomas A

“…A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be…”
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A comparison of the geographic patterns of HIV prevalence and hurricane events in the United States by Danielle Sharpe, J.

“…Previous research has documented the adverse association between hurricanes and HIV health outcomes; however, no research has been conducted to examine whether…”
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Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma by Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

“…Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers. Vismodegib is approved for the treatment of locally advanced…”
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Asymmetric Total Synthesis of the Indole Diterpene Alkaloid Paspaline by Sharpe, Robert J, Johnson, Jeffrey S

“…An enantioselective synthesis of the indole diterpenoid natural product paspaline is disclosed. Critical to this approach was the implementation of…”
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Back to basics: Making predictions in the orbitofrontal–amygdala circuit by Sharpe, Melissa J., Schoenbaum, Geoffrey

“…•BLA and OFC are critical to make predictions about motivationally-significant events.•The electrophysiological data reveal important differences in their…”
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Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response by Wolkin, Amy, Collier, Sarah, House, John S., Reif, David, Motsinger-Reif, Alison, Duca, Lindsey, Sharpe, J. Danielle

“…Objective: Vulnerability indices use quantitative indicators and geospatial data to examine the level of vulnerability to morbidity in a community. The Centers…”
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Oxysterols: Old Tale, New Twists by Luu, Winnie, Sharpe, Laura J, Capell-Hattam, Isabelle, Gelissen, Ingrid C, Brown, Andrew J

“…Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional…”
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Optimism and the Big Five factors of personality: Beyond Neuroticism and Extraversion by Sharpe, J. Patrick, Martin, Nicholas R., Roth, Kelly A.

“…► We examined relationships between optimism and the Big Five personality factors. ► Focused on relationships beyond Neuroticism and Extraversion. ► We used…”
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A process-based approach to health-related quality of life as a “way of living” by Nolan, R. P., Sharpe, M. J.

“…Introduction There is an historical initiative to establish common theoretical ground to support a framework for assessing health-related quality of life…”
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