Search Results - "Sharpe, D."

Tropical fish community does not recover 45 years after predator introduction by Sharpe, D. M. T., De León, L. F., González, R., Torchin, M. E.

“…Predation is considered to be an important factor structuring natural communities. However, it is often difficult to determine how it may influence long-term,…”
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Optimised Pre-Analytical Methods Improve KRAS Mutation Detection in Circulating Tumour DNA (ctDNA) from Patients with Non-Small Cell Lung Cancer (NSCLC) by Sherwood, James L, Corcoran, Claire, Brown, Helen, Sharpe, Alan D, Musilova, Milena, Kohlmann, Alexander

“…Non-invasive mutation testing using circulating tumour DNA (ctDNA) is an attractive premise. This could enable patients without available tumour sample to…”
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The Effect of Sepsis on the Erythrocyte by Bateman, Ryon M, Sharpe, Michael D, Singer, Mervyn, Ellis, Christopher G

“…Sepsis induces a wide range of effects on the red blood cell (RBC). Some of the effects including altered metabolism and decreased 2,3-bisphosphoglycerate are…”
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Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy by Downar, James, MDCM MHSc, Shemie, Sam D., MD, Gillrie, Clay, RN MSN, Fortin, Marie-Chantal, MD PhD, Appleby, Amber, RN MM, Buchman, Daniel Z., MSW PhD, Shoesmith, Christen, MD, Goldberg, Aviva, MD MA, Gruben, Vanessa, LLM, Lalani, Jehan, MHA, Ysebaert, Dirk, MD PhD, Wilson, Lindsay, MHA, Sharpe, Michael D., MD

“…In Canada, organ donation from deceased donors is a common practice that saves or improves the lives of more than nearly 2000 Canadians every year, accounting…”
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Disruptions of functional connectivity in the default mode network of comatose patients by NORTON, L, HUTCHISON, R. M, YOUNG, G. B, LEE, D. H, SHARPE, M. D, MIRSATTARI, S. M

“…To evaluate the possible role of the default mode network (DMN) in consciousness and assess the diagnostic or prognostic potential of DMN connectivity measures…”
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Contemporary phenotypic change in correlated characters in the African cyprinid, Rastrineobola argentea by Sharpe, D M T, Chapman, L J

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Siblings of Children With a Chronic Illness: A Meta-Analysis by Sharpe, Donald, Rossiter, Lucille

“…Objective: To review the literature pertaining to the siblings of children with a chronic illness. Methods: Fifty-one published studies and 103 effect sizes…”
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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death by Scott, Duncan E, Francis-Newton, Nicola J, Marsh, May E, Coyne, Anthony G, Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R, Sharpe, Timothy D, Haas, Kalina T, Barber, Lorraine, Valenzano, Chiara R, Srinivasan, Rajavel, Huggins, David J, Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L, Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R, Abell, Chris

“…BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51…”
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Testing the prey naiveté hypothesis: Can native prey (Astyanax ruberrimus) recognize an introduced top predator, Cichla monoculus? by Sharpe, D. M. T., de Lira, J. J. P. R., Brown, G. E., Torchin, M. E., Hendry, A. P.

“…The prey naiveté hypothesis (PNH) posits that prey will often fail to recognize and respond to introduced predators with whom they do not share a…”
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Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry by Smith, Clive A, Li, Xin, Mize, Todd H, Sharpe, Timothy D, Graziani, Edmund I, Abell, Chris, Huck, Wilhelm T. S

“…Droplet-based fluidics is emerging as a powerful platform for single cell analysis, directed evolution of enzymes, and high throughput screening studies. Due…”
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Use of Advanced Flexible Modeling Approaches for Survival Extrapolation from Early Follow-up Data in two Nivolumab Trials in Advanced NSCLC with Extended Follow-up by Chaudhary, M. A., Edmondson-Jones, M., Baio, G., Mackay, E., Penrod, J. R., Sharpe, D. J., Yates, G., Rafiq, S., Johannesen, K., Siddiqui, M. K., Vanderpuye-Orgle, J., Briggs, A.

“…Objectives Immuno-oncology (IO) therapies are often associated with delayed responses that are deep and durable, manifesting as long-term survival benefits in…”
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Antiarrhythmic effect of carvedilol after acute myocardial infarction: results of the Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction (CAPRICORN) trial by McMurray, John, Køber, Lars, Robertson, Michele, Dargie, Henry, Colucci, Wilson, Lopez-Sendon, Jose, Remme, Willem, Sharpe, D Norman, Ford, Ian

“…Whether beta-blockers reduce atrial arrhythmias and, when added to an angiotensin-converting enzyme (ACE) inhibitor, ventricular arrhythmia is unknown…”
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Efficacy of a Lidocaine-Impregnated Elastrator Band for Castration and Tail Docking in Lambs by Roche, Steven M, Ralston, Brenda J, Olson, Barbara, Sharpe, Brendan D, Schatz, Crystal, Beaugrand, Kendall, Ross, Joseph A, Broomfield, Madeleine A, Allan, Nicolas, Olson, Merle

“…The primary objective of this study was to demonstrate the non-inferiority between lidocaine-impregnated ligation bands (LLBs) and control bands (CBs) with…”
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General Structural Motifs of Amyloid Protofilaments by Ferguson, Neil, Becker, Johanna, Tidow, Henning, Tremmel, Sandra, Sharpe, Timothy D., Krause, Gerd, Flinders, Jeremy, Petrovich, Miriana, Berriman, John, Oschkinat, Hartmut, Fersht, Alan R.

“…Human CA150, a transcriptional activator, binds to and is codeposited with huntingtin during Huntington's disease. The second WW domain of CA150 is a…”
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The impact of an antibiotic specific prescription form in the accident and emergency department by Sharpe, D, Kapas, S

“…Aims An antibiotic specific prescription for use in the Accident and Emergency Department (AED) has recently been introduced to encourage appropriate…”
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Adherence to general surgery prophylaxis guidelines at Alder Hey Children's Hospital by Todd, C, Sharpe, D

“…Objective The aim of surgical prophylaxis is to reduce the risk of developing surgical site infections. SIGN guidelines1 suggest that in most cases a single…”
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Little evidence for morphological change in a resilient endemic species following the introduction of a novel predator by Sharpe, D. M. T., Langerhans, R. B., Low‐Décarie, E., Chapman, L. J.

“…Human activities, such as species introductions, are dramatically and rapidly altering natural ecological processes and often result in novel selection…”
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Distinguishing between Cooperative and Unimodal Downhill Protein Folding by Huang, Fang, Sato, Satoshi, Sharpe, Timothy D., Ying, Liming, Fersht, Alan R.

“…Conventional cooperative protein folding invokes discrete ensembles of native and denatured state structures in separate free-energy wells. Unimodal…”
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Multiple Symmetrical Lipomatosis--a mitochondrial disorder of brown fat by Plummer, C, Spring, P J, Marotta, R, Chin, J, Taylor, G, Sharpe, D, Athanasou, N A, Thyagarajan, D, Berkovic, S F

“…Multiple Symmetrical Lipomatosis (MSL) is an unusual disorder characterized by the development of axial lipomas in adulthood. The pathoetiology of lipoma…”
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Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4 by Filippakopoulos, Panagis, Low, Andrew, Sharpe, Timothy D., Uppenberg, Jonas, Yao, Shenggen, Kuang, Zhihe, Savitsky, Pavel, Lewis, Rowena S., Nicholson, Sandra E., Norton, Raymond S., Bullock, Alex N.

“…The mammalian SPRY domain- and SOCS box-containing proteins, SPSB1 to SPSB4, belong to the SOCS box family of E3 ubiquitin ligases. Substrate recognition sites…”
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