Search Results - "Sharpe, Arlene H"

Introduction to checkpoint inhibitors and cancer immunotherapy by Sharpe, Arlene H.

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The diverse functions of the PD1 inhibitory pathway by Sharpe, Arlene H., Pauken, Kristen E.

“…Key Points Programmed cell death protein 1 (PD1) is an inhibitory receptor that is expressed by all T cells during activation. It regulates T cell effector…”
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ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity by Maazi, Hadi, Patel, Nisheel, Sankaranarayanan, Ishwarya, Suzuki, Yuzo, Rigas, Diamanda, Soroosh, Pejman, Freeman, Gordon J., Sharpe, Arlene H., Akbari, Omid

“…Allergic asthma is caused by Th2-cell-type cytokines in response to allergen exposure. Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of…”
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Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family by Schildberg, Frank A., Klein, Sarah R., Freeman, Gordon J., Sharpe, Arlene H.

“…Immune responses need to be controlled for optimal protective immunity and tolerance. Coinhibitory pathways in the B7-CD28 family provide critical inhibitory…”
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Coinhibitory Pathways in Immunotherapy for Cancer by Baumeister, Susanne H, Freeman, Gordon J, Dranoff, Glenn, Sharpe, Arlene H

“…The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor…”
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Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses by Joller, Nicole, Lozano, Ester, Burkett, Patrick R., Patel, Bonny, Xiao, Sheng, Zhu, Chen, Xia, Junrong, Tan, Tze G., Sefik, Esen, Yajnik, Vijay, Sharpe, Arlene H., Quintana, Francisco J., Mathis, Diane, Benoist, Christophe, Hafler, David A., Kuchroo, Vijay K.

“…Foxp3+ T regulatory (Treg) cells regulate immune responses and maintain self-tolerance. Recent work shows that Treg cells are comprised of many subpopulations…”
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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells by Sage, Peter T., Paterson, Alison M., Lovitch, Scott B., Sharpe, Arlene H.

“…The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here…”
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PD-1 pathway in tolerance and autoimmunity by Francisco, Loise M, Sage, Peter T, Sharpe, Arlene H

“…Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the…”
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Emerging concepts in PD-1 checkpoint biology by Pauken, Kristen E., Torchia, James A., Chaudhri, Apoorvi, Sharpe, Arlene H., Freeman, Gordon J.

“…•The PD-1 pathway plays multifaceted roles in regulating immune responses.•PD-1 can modulate effector and memory T cells, Treg cells, NK cells, and ILCs.•PD-1…”
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Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms by Moslehi, Javid, Lichtman, Andrew H, Sharpe, Arlene H, Galluzzi, Lorenzo, Kitsis, Richard N

“…Immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers, including malignancies once considered untreatable. These agents,…”
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway by Evavold, Charles L., Hafner-Bratkovič, Iva, Devant, Pascal, D’Andrea, Jasmin M., Ngwa, Elsy M., Boršić, Elvira, Doench, John G., LaFleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C.

“…The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated…”
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Roles of CD48 in regulating immunity and tolerance by McArdel, Shannon L, Terhorst, Cox, Sharpe, Arlene H

“…Abstract CD48, a member of the signaling lymphocyte activation molecule family, participates in adhesion and activation of immune cells. Although…”
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Inhibitors of the PD-1 Pathway in Tumor Therapy by LaFleur, Martin W, Muroyama, Yuki, Drake, Charles G, Sharpe, Arlene H

“…The programmed death 1 (PD-1) pathway delivers inhibitory signals that function as a brake for immune responses. This pathway limits the initiation and…”
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CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease by Sakai, Shunsuke, Kauffman, Keith D, Sallin, Michelle A, Sharpe, Arlene H, Young, Howard A, Ganusov, Vitaly V, Barber, Daniel L

“…IFN-γ-producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to…”
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity by Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.

“…Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not…”
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Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth by Kleffel, Sonja, Posch, Christian, Barthel, Steven R., Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P., Lee, Nayoung, Juneja, Vikram R., Zhan, Qian, Lian, Christine G., Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Martin C., Flaherty, Keith T., Frank, Markus H., Murphy, George F., Sharpe, Arlene H., Kupper, Thomas S., Schatton, Tobias

“…Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of…”
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PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity by Helou, Doumet Georges, Shafiei-Jahani, Pedram, Lo, Richard, Howard, Emily, Hurrell, Benjamin P., Galle-Treger, Lauriane, Painter, Jacob D., Lewis, Gavin, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid

“…Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper…”
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T Cell Activation Depends on Extracellular Alanine by Ron-Harel, Noga, Ghergurovich, Jonathan M., Notarangelo, Giulia, LaFleur, Martin W., Tsubosaka, Yoshiki, Sharpe, Arlene H., Rabinowitz, Joshua D., Haigis, Marcia C.

“…T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine,…”
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation by Ron-Harel, Noga, Santos, Daniel, Ghergurovich, Jonathan M., Sage, Peter T., Reddy, Anita, Lovitch, Scott B., Dephoure, Noah, Satterstrom, F. Kyle, Sheffer, Michal, Spinelli, Jessica B., Gygi, Steven, Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.

“…Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naive CD4+ T cell…”
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Editorial Expression of Concern: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin by Ryeom, Sandra, Greenwald, Rebecca. J, Sharpe, Arlene. H, McKeon, Frank

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