Search Results - "Sharp, P P"
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Global modeling of nature's contributions to people
Published in Science (American Association for the Advancement of Science) (11-10-2019)“…The magnitude and pace of global change demand rapid assessment of nature and its contributions to people. We present a fine-scale global modeling of current…”
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Deep surface rolling for fatigue life enhancement of laser clad aircraft aluminium alloy
Published in Applied surface science (30-11-2014)“…•Deep surface rolling as a post-repair enhancement technology was applied to the laser cladded 7075-T651 aluminium alloy specimens that simulated corrosion…”
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Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons
Published in Cerebral cortex (New York, N.Y. 1991) (14-04-2020)“…Abstract Inhibitory interneurons can evoke vasodilation and vasoconstriction, making them potential cellular drivers of neurovascular coupling. However, the…”
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Spatial patterns of agricultural expansion determine impacts on biodiversity and carbon storage
Published in Proceedings of the National Academy of Sciences - PNAS (16-06-2015)“…The agricultural expansion and intensification required to meet growing food and agri-based product demand present important challenges to future levels and…”
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RNA interference--2001
Published in Genes & development (01-03-2001)“…In the few years since the discovery of RNA interference (RNAi), it has become clear that this process is ancient. RNAi, the oldest and most ubiquitous…”
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The performance of the N-body integrator SSS
Published in Numerical algorithms (01-08-2019)“…The integrator SSS performs accurate N -body simulations of the Solar System when there is a mix of massive bodies and test particles. The orbital motion of…”
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Evidence for elevated mutation rates in low-quality genotypes
Published in Proceedings of the National Academy of Sciences - PNAS (17-04-2012)“…The deleterious mutation rate plays a key role in a number of important topics in biology, from mating system evolution to human health. Despite this broad…”
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Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)
Published in European heart journal (17-04-2023)“…Abstract Since the publication of the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) Guidelines for the Management of Arterial…”
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BET bromodomain inhibitors: a patent review
Published in Expert opinion on therapeutic patents (01-02-2014)“…The bromodomain (BRD) and extra-C terminal domain (BET) protein family consists of four members (BRD2, BRD3, BRD4 and BRDT). These "epigenetic readers" bind to…”
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BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells
Published in Leukemia (01-07-2016)“…The BET ( b romodomain and e xtra t erminal domain) bromodomain-containing proteins, such as BRD4, are highly promising targets for treating lymphoid and…”
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Low Genetic Quality Alters Key Dimensions of the Mutational Spectrum
Published in PLoS biology (25-03-2016)“…Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies…”
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A systematic review of participatory engagement in men’s health promotion programs
Published in Journal of science and medicine in sport (01-11-2022)Get full text
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Mapping the planet’s critical areas for biodiversity and nature’s contributions to people
Published in Nature communications (10-01-2024)“…Meeting global commitments to conservation, climate, and sustainable development requires consideration of synergies and tradeoffs among targets. We evaluate…”
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Gene silencing in mammals by small interfering RNAs
Published in Nature reviews. Genetics (01-10-2002)“…Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them…”
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Improving wheat as a source of iron and zinc for global nutrition
Published in Nutrition bulletin (01-03-2019)“…Wheat is the staple food crop in temperate countries and increasingly consumed in developing countries, displacing traditional foods. However, wheat products…”
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Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
Published in Neuropathology and applied neurobiology (01-12-2017)“…Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful…”
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Metric space formulation of quantum mechanical conservation laws
Published in Physical review. B, Condensed matter and materials physics (31-03-2014)“…We show that conservation laws in quantum mechanics naturally lead to metric spaces for the set of related physical quantities. All such metric spaces have an…”
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Can pitting corrosion change the location of fatigue failures in aircraft?
Published in International journal of fatigue (01-04-2014)“…•A Monte Carlo model was developed to predict the fatigue life of 7010-T7651.•The material was modeled as low-kt specimens in pitted and uncorroded states.•It…”
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A family-based approach examining perceptions of a TRYathlon series on children’s health and development
Published in Journal of science and medicine in sport (01-11-2022)Get full text
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