Search Results - "Sharp, M E"

Feasibility study for an automated engineering change process by Sharp, M. E., Hedberg, T. D., Bernstein, W. Z., Kwon, S.

“…Engineering change is a significant cost for projects. While avoiding and mitigating the risk of change is ideal, mistakes and improvements are recognised as…”
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What is the best initial treatment in Parkinson's disease? by Sharp, M E, Mazzoni, P

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Defining requirements for integrating information between design, manufacturing, and inspection by Hedberg, T. D., Sharp, M. E., Maw, T. M. M., Helu, M. M., Rahman, M. M., Jadhav, S., Whicker, J. J., Barnard Feeney, A.

“…Industry desires a digital thread of information that aligns as-designed, as-planned, as-executed, and as-inspected viewpoints. An experiment was conducted to…”
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A Comprehensive Screen for Volatile Organic Compounds in Biological Fluids by Sharp, Mary-Ellen E.

“…A headspace gas chromatographic (GC) screen for common volatile organic compounds in biological fluids is reported. Common GC phases, DB-1™ and DB-WAX™, with…”
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Molecular Determinants of Voltage-dependent Gating and Binding of Pore-blocking Drugs in Transmembrane Segment IIIS6 of the Na+ Channel α Subunit by Yarov-Yarovoy, Vladimir, Brown, Jacob, Sharp, Elizabeth M., Clare, Jeff J., Scheuer, Todd, Catterall, William A.

“…Mutations of amino acid residues in the inner two-thirds of the S6 segment in domain III of the rat brain type IIA Na+ channel (G1460A to I1473A) caused…”
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Ether: Stability in Preserved Blood Samples and a Case of Ether-Assisted Suicide by Sharp, Mary-Ellen E., Dautbegovic, Tijana

“…Ethyl ether was detected in the blood of a deceased individual who had inhaled it from a mask while hanging himself. This case led to an investigation into the…”
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Inhibition of Cardiac L-Type Calcium Channels by Protein Kinase C Phosphorylation of Two Sites in the N-Terminal Domain by McHugh, Damian, Sharp, Elizabeth M., Scheuer, Todd, Catterall, William A.

“…We have investigated the mechanism underlying the modulation of the cardiac L-type Ca2+current by protein kinase C(PKC). Using the patch-clamp technique, we…”
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A three-base-pair deletion in the peripherin- RDS gene in one form of retinitis pigmentosa by Farrar, G. Jane, Kenna, Paul, Jordan, Siobhán A, Kumar-Singh, Rajendra, Humphries, Marian M, Sharp, Elizabeth M, Sheils, Denise M, Humphries, Peter

“…The group of retinopathies termed retinitis pigmentosa (RP) greatly contribute to visual dysfunction in man with a frequency of roughly 1 in 4,000. We mapped…”
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Autosomal dominant retinitis pigmentosa: a novel mutation at the peripherin/RDS locus in the original 6p-linked pedigree by Farrar, G J, Kenna, P, Jordan, S A, Kumar-Singh, R, Humphries, M M, Sharp, E M, Sheils, D, Humphries, P

“…Using single-strand conformation polymorphism electrophoresis, heteroduplex analysis, and direct sequencing, we have searched for possible disease-causing…”
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Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline----histidine substitution (codon 23) in pedigrees from Europe by Farrar, G J, Kenna, P, Redmond, R, McWilliam, P, Bradley, D G, Humphries, M M, Sharp, E M, Inglehearn, C F, Bashir, R, Jay, M

“…In exon 1 at codon 23 of the rhodopsin gene, a mutation resulting in a proline-to-histidine substitution has previously been observed in approximately 12% of…”
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A rapid screening procedure for acidic and neutral drugs in blood by high resolution gas chromatography by Sharp, M E

“…A rapid high resolution gas chromatographic method for screening acidic and neutral drugs in blood is described. The procedure involves a single extraction…”
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Autosomal dominant retinitis pigmentosa: exclusion of the gene from the short arm of chromosome I including the region surrounding the rhesus locus by BRADLEY, D. G, JANE FARRAR, G, SHARP, E. M, KENNA, P, HUMPHRIES, M. M, MCCONNELL, D. J, DAIGER, S. P, MCWILLIAM, P, HUMPHRIES, P

“…Members of a large Irish pedigree exhibiting early-onset autosomal dominant retinitis pigmentosa (ADRP) were typed for the rhesus blood group and nine DNA…”
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Epidermolysis bullosa: evidence for linkage to genetic markers on chromosome 1 in a family with the autosomal dominant simplex form by Humphries, M M, Sheils, D, Lawler, M, Farrar, G J, McWilliam, P, Kenna, P, Bradley, D G, Sharp, E M, Gaffney, E F, Young, M

“…DNA from members of a three-generation pedigree of Irish origin, displaying an autosomal dominant simplex form of epidermolysis bullosa of the epidermolytic,…”
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The Utah education network: a collaborative model by Peay, W J, Hess, S H, Sharp, E M

“…High-speed data communications networks are transforming the operations, services, and roles of libraries. While the installation of the physical network is…”
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Localization of an autosomal dominant retinitis pigmentosa gene to chromosome 7q by Sharp, Elizabeth M, Humphries, Peter, Farrar, G. Jane, Ayuso, Carmen, Kumar-Singh, Rajendra, Jordan, Siobhán A, Benitez, Javier, Kenna, Paul, Soriano, Nuria, Sheils, Denise M, Humphries, Marian M

“…Retinitis pigmentosa is a group of clinically and genetically heterogeneous retinopathies and a significant cause of worldwide visual handicap. We have typed…”
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Monitoring saliva concentrations of methaqualone, codeine, secobarbital, diphenhydramine and diazepam after single oral doses by Sharp, M E, Wallace, S M, Hindmarsh, K W, Peel, H W

“…A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the…”
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Acetylator phenotype and serum levels of sulfapyridine in patients with inflammatory bowel disease by Sharp, M E, Wallace, S M, Hindmarsh, K W, Brown, M A

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Autosomal dominant retinitis pigmentosa: a mutation in codon 178 of the rhodopsin gene in two families of Celtic origin by Farrar, G J, Kenna, P, Redmond, R, Shiels, D, McWilliam, P, Humphries, M M, Sharp, E M, Jordan, S, Kumar-Singh, R, Humphries, P

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Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity by Farrar, G J, McWilliam, P, Bradley, D G, Kenna, P, Lawler, M, Sharp, E M, Humphries, M M, Eiberg, H, Conneally, P M, Trofatter, J A

“…Retinitis pigmentosa (RP) is the most prevalent human retinopathy of genetic origin. Chromosomal locations for X-linked RP and autosomal dominant RP genes have…”
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STUDIES IN DENERVATION: G.-SEBACEOUS SECRETION by Doupe, J, Sharp, M E

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